IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- Tenascin-C at a glance
Summary: Tenascin-C is an extracellular matrix molecule that shapes cell behavior in developing and traumatized tissues, and has a great potential in disease diagnosis and tissue repair.
COMMENTARY
- Mechanisms and functions of lysosome positioning
Summary: We review recent findings on the mechanisms that mediate the motility and positioning of lysosomes, and the importance of lysosome dynamics for cell physiology and pathology.
RESEARCH ARTICLES
- The role and regulation of Rab40b–Tks5 complex during invadopodia formation and cancer cell invasion
Highlighted Article: Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion by binding to Tks5 and functioning as a tether mediating MMP2 and MMP9 targeting to the extending invadopodia.
- Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes
Summary: Development is more sensitive to gain of vinculin activity than its loss, and vinculin can promote cytoplasmic adhesion complexes independently of the usual integrin cue.
- Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein
Highlighted Article: The functional impact of missense mutations is difficult to predict. Yeast cells detect the misfolding effects of these types of mutations in the human BRCA1 protein, revealing an associated nuclear transport impairment.
- CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa
Summary: Removal of Cabyr by using CRISPR-Cas9 results in mouse spermatozoa with a disorganized fibrous sheath, impaired motility and a subsequent loss of their ability to fertilize oocytes.
- Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes
Highlighted Article: The availability of the membrane tether junctophilin-2 determines the nanostructure of the fast intracellular Ca2+ signalling junctions but, if present above a minimum required level, forms an auto-regulatory mechanism which maintains local Ca2+ signals broadly independent of the structural differences.
- Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration
Summary: Gap junction expression has been linked to enhanced metastasis and cell migration. We show here that Cx26 gap junctions selectively enhance cell migration by disrupting N-cadherin-based cell adhesion in HeLa cells.
- Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
Highlighted Article: Dysfunction of mitochondria and subsequently energy generation occurs in many human diseases. Here, we propose a mechanism that allows rapid activation of glucose influx to prevent energy crisis during such dysfunction.
- Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus
Summary: The class III PI3K Vps34 activates Armus (TBC1D2), a Rab7 GTPase-activating protein, to regulate endosomal trafficking.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
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JCS and COVID-19
For more information on measures Journal of Cell Science is taking to support the community during the COVID-19 pandemic, please see here.
If you have any questions or concerns, please do not hestiate to contact the Editorial Office.
The Company of Biologists commits to the Transformative Journal approach
The Company of Biologists is the first not-for-profit publisher to commit to this approach. The Company’s three hybrid journals - Development, Journal of Cell Science and Journal of Experimental Biology - have chosen the ‘transformative’ route towards Open Access. Find out more in this interview with Claire Moulton, Publisher at The Company of Biologists and on our dedicated Transformative Journals page.
Extended deadline - Special Issue on Cell Biology of Host-Pathogen Interactions
We have extended the deadline for submissions for our next special issue, which will be guest-edited by Derek Walsh (Northwestern University, USA). Submission deadline is now 15 September 2020 - find out more.
The Corona Files
“Most of the scientists I know are frogs, by which I mean, they will happily lend a hand to their colleagues if their expertise would be helpful in solving an interesting problem.”
Our resident insectivore, Mole, continues his latest series – The Corona Files. Catch up on Mole’s weekly musings on how COVID-19 is changing the landscape for researchers.
Science and art – the not so odd couple?
Over on FocalPlane, Sophie Morgani discusses the somewhat surprising relationship between science and art.
First person interview - Eryn Dixon
Eryn Dixon is first author of a new Tools & Resources paper that presents a new model system that generates kidney tubule-like structures in a dish. Find out more about Eryn and her research in an interview.