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December, 2016; 129 (23)

IN THIS ISSUE

  • You have accessSubscription required
    Rab40b and Tks5 interact at invadopodia during metastasis
    Journal of Cell Science 2016 129: e2301
  • You have accessSubscription required
    Yeast cells detect human BRCA1 misfolding
    Journal of Cell Science 2016 129: e2302
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    A nanoscale view of junctophilin-2 and ryanodine receptors
    Journal of Cell Science 2016 129: e2303
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    AMPK and Sirt2 control compensatory glucose uptake
    Journal of Cell Science 2016 129: e2304

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Brian Stramer
    Journal of Cell Science 2016 129: 4319-4320; doi: 10.1242/jcs.197830

CELL SCIENCE AT A GLANCE

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    Tenascin-C at a glance
    Kim S. Midwood, Matthias Chiquet, Richard P. Tucker, Gertraud Orend
    Journal of Cell Science 2016 129: 4321-4327; doi: 10.1242/jcs.190546

    Summary: Tenascin-C is an extracellular matrix molecule that shapes cell behavior in developing and traumatized tissues, and has a great potential in disease diagnosis and tissue repair.

COMMENTARY

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    Mechanisms and functions of lysosome positioning
    Jing Pu, Carlos M. Guardia, Tal Keren-Kaplan, Juan S. Bonifacino
    Journal of Cell Science 2016 129: 4329-4339; doi: 10.1242/jcs.196287

    Summary: We review recent findings on the mechanisms that mediate the motility and positioning of lysosomes, and the importance of lysosome dynamics for cell physiology and pathology.

RESEARCH ARTICLES

  • Open Access
    The role and regulation of Rab40b–Tks5 complex during invadopodia formation and cancer cell invasion
    Abitha Jacob, Erik Linklater, Brian A. Bayless, Traci Lyons, Rytis Prekeris
    Journal of Cell Science 2016 129: 4341-4353; doi: 10.1242/jcs.193904

    Highlighted Article: Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion by binding to Tks5 and functioning as a tether mediating MMP2 and MMP9 targeting to the extending invadopodia.

  • Open Access
    Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes
    Aidan P. Maartens, Jutta Wellmann, Emma Wictome, Benjamin Klapholz, Hannah Green, Nicholas H. Brown
    Journal of Cell Science 2016 129: 4354-4365; doi: 10.1242/jcs.189878

    Summary: Development is more sensitive to gain of vinculin activity than its loss, and vinculin can promote cytoplasmic adhesion complexes independently of the usual integrin cue.

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    Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein
    Pierre Thouvenot, Lou Fourrière, Elodie Dardillac, Barbara Ben Yamin, Aurianne Lescure, Vincent Lejour, Xavier Heiligenstein, Jean-Baptiste Boulé, Maryse Romao, Graça Raposo-Benedetti, Bernard S. Lopez, Alain Nicolas, Gaël A. Millot
    Journal of Cell Science 2016 129: 4366-4378; doi: 10.1242/jcs.192880

    Highlighted Article: The functional impact of missense mutations is difficult to predict. Yeast cells detect the misfolding effects of these types of mutations in the human BRCA1 protein, revealing an associated nuclear transport impairment.

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    CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa
    Samantha A. M. Young, Haruhiko Miyata, Yuhkoh Satouh, Robert John Aitken, Mark A. Baker, Masahito Ikawa
    Journal of Cell Science 2016 129: 4379-4387; doi: 10.1242/jcs.193151

    Summary: Removal of Cabyr by using CRISPR-Cas9 results in mouse spermatozoa with a disorganized fibrous sheath, impaired motility and a subsequent loss of their ability to fertilize oocytes.

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    Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes
    Michelle L. Munro, Isuru D. Jayasinghe, Qiongling Wang, Ann Quick, Wei Wang, David Baddeley, Xander H. T. Wehrens, Christian Soeller
    Journal of Cell Science 2016 129: 4388-4398; doi: 10.1242/jcs.196873

    Highlighted Article: The availability of the membrane tether junctophilin-2 determines the nanostructure of the fast intracellular Ca2+ signalling junctions but, if present above a minimum required level, forms an auto-regulatory mechanism which maintains local Ca2+ signals broadly independent of the structural differences.

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    Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration
    Srikanth R. Polusani, Edward A. Kalmykov, Anjana Chandrasekhar, Shoshanna N. Zucker, Bruce J. Nicholson
    Journal of Cell Science 2016 129: 4399-4410; doi: 10.1242/jcs.185017

    Summary: Gap junction expression has been linked to enhanced metastasis and cell migration. We show here that Cx26 gap junctions selectively enhance cell migration by disrupting N-cadherin-based cell adhesion in HeLa cells.

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    Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
    Dania C. Liemburg-Apers, Jori A. L. Wagenaars, Jan A. M. Smeitink, Peter H. G. M. Willems, Werner J. H. Koopman
    Journal of Cell Science 2016 129: 4411-4423; doi: 10.1242/jcs.194480

    Highlighted Article: Dysfunction of mitochondria and subsequently energy generation occurs in many human diseases. Here, we propose a mechanism that allows rapid activation of glucose influx to prevent energy crisis during such dysfunction.

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    Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus
    Nadia Jaber, Noor Mohd-Naim, Ziqing Wang, Jennifer L. DeLeon, Seong Kim, Hua Zhong, Namratha Sheshadri, Zhixun Dou, Aimee L. Edinger, Guangwei Du, Vania M. M. Braga, Wei-Xing Zong
    Journal of Cell Science 2016 129: 4424-4435; doi: 10.1242/jcs.192260

    Summary: The class III PI3K Vps34 activates Armus (TBC1D2), a Rab7 GTPase-activating protein, to regulate endosomal trafficking.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Development

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      Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells
      Courtney R. Bone, Yu-Tai Chang, Natalie E. Cain, Shaun P. Murphy, Daniel A. Starr
      Journal of Cell Science 2016 129: e1.1 doi: 10.1242/jcs.199646
    • You have accessSubscription required
      A new mode of mitochondrial transport and polarized sorting regulated by Dynein, Milton and Miro
      Anna Melkov, Raju Baskar, Yehonatan Alcalay, Uri Abdu
      Journal of Cell Science 2016 129: e1.2 doi: 10.1242/jcs.199653
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Journal of Cell Science: 129 (23)
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    SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72

    Mirjana Malnar, Boris Rogelj
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    Calcium elevations disrupt interactions between intraflagellar transport and the flagella membrane in Chlamydomonas

    Cecile Fort, Peter Collingridge, Colin Brownlee, Glen Wheeler
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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