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Research Article
Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor
Spencer A. Freeman, Sonja Christian, Pamela Austin, Irene Iu, Marcia L. Graves, Lin Huang, Shuo Tang, Daniel Coombs, Michael R. Gold, Calvin D. Roskelley
Journal of Cell Science 2017 130: 152-163; doi: 10.1242/jcs.180612
Spencer A. Freeman
1Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
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Sonja Christian
2Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
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Pamela Austin
3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
4Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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Irene Iu
3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
4Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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Marcia L. Graves
3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
4Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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Lin Huang
5Department of Electrical Engineering, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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Shuo Tang
5Department of Electrical Engineering, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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Daniel Coombs
6Department of Mathematics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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Michael R. Gold
2Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
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Calvin D. Roskelley
3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
4Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
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  • ORCID record for Calvin D. Roskelley
  • For correspondence: roskelly@mail.ubc.ca
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Article Information

vol. 130 no. 1, 152-163

DOI 
https://doi.org/10.1242/jcs.180612
PubMed 
27199371

Published By 
The Company of Biologists Ltd
Print ISSN 
0021-9533
Online ISSN 
1477-9137
History 
  • Received September 24, 2015
  • Accepted May 13, 2016
  • Published online January 2, 2017.
Posted online 
May 19, 2016
Copyright & Usage 
© 2017. Published by The Company of Biologists Ltd http://www.biologists.com/user-licence-1-1/

Article Versions

  • Previous version (May 19, 2016 - 04:07).
  • Previous version (July 5, 2016 - 04:45).
  • You are viewing the most recent version of this article.

Author Information

  1. Spencer A. Freeman1,
  2. Sonja Christian2,3,
  3. Pamela Austin3,4,
  4. Irene Iu3,4,
  5. Marcia L. Graves3,4,
  6. Lin Huang5,
  7. Shuo Tang5,
  8. Daniel Coombs6,
  9. Michael R. Gold2,3 and
  10. Calvin D. Roskelley3,4,*
  1. 1Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
  2. 2Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
  3. 3Life Sciences Institute, University of British Columbia, 2350 Health Sciences Road, Vancouver, British Columbia, V6T 1Z3, Canada
  4. 4Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
  5. 5Department of Electrical Engineering, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
  6. 6Department of Mathematics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
  1. ↵*Author for correspondence (roskelly{at}mail.ubc.ca)

    Article usage

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    Keywords

    • Mechanotransduction
    • Rap GTPases
    • Focal adhesions
    • Actin cytoskeleton
    • Talin
    • Vinculin
    • integrin

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    Research Article
    Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor
    Spencer A. Freeman, Sonja Christian, Pamela Austin, Irene Iu, Marcia L. Graves, Lin Huang, Shuo Tang, Daniel Coombs, Michael R. Gold, Calvin D. Roskelley
    Journal of Cell Science 2017 130: 152-163; doi: 10.1242/jcs.180612
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    Research Article
    Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor
    Spencer A. Freeman, Sonja Christian, Pamela Austin, Irene Iu, Marcia L. Graves, Lin Huang, Shuo Tang, Daniel Coombs, Michael R. Gold, Calvin D. Roskelley
    Journal of Cell Science 2017 130: 152-163; doi: 10.1242/jcs.180612

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