IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- Pseudostratified epithelia – cell biology, diversity and roles in organ formation at a glance
Summary: Here, we give readers an overview of the biology and characteristics of pseudostratified epithelia.
COMMENTARY
- Caught in the act – protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease
Summary: We summarize how the vertebrate PACS proteins acquired specific motifs that enabled them to function as metabolic switches that integrate cytoplasmic membrane trafficking and interorganellar communication with nuclear gene expression.
RESEARCH ARTICLES
- SNAP-25 gene family members differentially support secretory vesicle fusion
Highlighted Article: SNAP-25 family members differentially support neuron survival, and dense-core and synaptic vesicle fusion in Snap-25-null mutant neurons.
- PTK7 localization and protein stability is affected by canonical Wnt ligands
Summary: In the presence of canonical Wnt proteins, the regulator of planar cell polarity PTK7 is endocytosed and degraded in lysosomes. By contrast, PTK7 inhibits canonical Wnt signaling suggesting a mechanism of mutual inhibition.
- 3D motion of vesicles along microtubules helps them to circumvent obstacles in cells
Highlighted Article: We develop a new method to track vesicle dynamics in three dimensions and show that vesicles change their position while actively transporting along microtubules in living cells to overcome obstacles.
- Spatiotemporal regulation of cell fusion by JNK and JAK/STAT signaling during Drosophila wound healing
Summary: During Drosophila wound healing, JAK/STAT signaling restricts cell fusion to the periphery of the wound, whereas in the wound vicinity, JAK/STAT signaling is inhibited by fusion-promoting JNK signaling.
- A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells
Highlighted Article: Secretagogues stimulating mitochondria in pancreatic β-cells act by two different mechanisms to promote insulin secretion. The pathways are distinct in their dependence on ATP-synthase, Ca2+ signals and redox changes.
- CLUH couples mitochondrial distribution to the energetic and metabolic status
Summary: Mitochondrial distribution within the cell is critical for supplying ATP at specific sites. We show here that CLUH couples mitochondrial distribution to the energetic and metabolic status in human cells.
- Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC
Highlighted Article: p38-MAPK-mediated induction of NOTCH3 is required for prostate epithelial differentiation; this is mediated in part via MYC and enhancer-driven transcription, as well as enhanced mRNA stability.
- Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro
Summary: Tugging on ECM fibers promotes the maturation of invadopodia and cell invasion in highly invasive cancer cells. This specific form of mechanical signaling downregulates integrin β3 resulting in increased cofilin activity.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Development
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Other journals from The Company of Biologists
Editorial – The good, the bad and the very useful – at least to cell biologists
Editor-in-Chief, Michael Way, discusses the exciting potential of examining the intimate relationship between pathogens, cells and hosts for cell biology research. Submissions are welcome for the fifth JCS Special Issue, guest edited by Derek Walsh, focussing on host-pathogen interactions.
Cell Science at a Glance – The fusogenic synapse at a glance
In their Cell Science at a Glance, Ji Hoon Jim and Elizabeth H. Chen highlight the molecular, cellular and biophysical events at the asymmetric fusogenic synapse.
Review – Force-generating mechanisms of anaphase in human cells
Kruno Vukušić, Renata Buđa and Iva M. Tolić review contributions of force-generating mechanisms, acting through different microtubule populations, to chromosome segregation in human cells.
First Person interviews
Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Bouchra Khalaf, Bapi Sarker, Amrit Bagchi and Tak Shun Fung.
Mole – Impact! III
“Over the last five years, there were 1,141,540 papers published per year that were listed in PubMed. If you read them for 8 h per day, 5 days week, for 50 weeks year, you would have to read about ten papers a minute to read them all.”
Read Mole’s thoughts on the issue of impact in scientific literature.
preLights – preLights reaches 500 posts!
The success of preLights is down to the hard work of our preLighters. Head over to the preLights website to find out more about our most active early-career-researchers.
Journal Meeting – Cell Dynamics: Host-Pathogen Interface
Registration is now open for the third instalment of the highly successful Cellular Dynamics Meeting Series, which will take place on 17-20 May 2020 and will focus on ‘Host-Pathogen Interface’.
Articles of interest in our sister journals
Scribble and Discs Large mediate tricellular junction formation
Zohreh Sharifkhodaei, Mary M. Gilbert, Vanessa J. Auld (Development 2019 146: dev174763)
Annabel Ebbing, Teije C. Middelkoop, Marco C. Betist, Eduard Bodewes, Hendrik C. Korswagen (Development 2019 146: dev180059)