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October, 2017; 130 (20)

IN THIS ISSUE

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    LPA breakdown in melanoma invasion
    Journal of Cell Science 2017 130: e2001
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    USP10: a novel antifibrotic target
    Journal of Cell Science 2017 130: e2002
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    Atlastin in presynaptic terminal organisation
    Journal of Cell Science 2017 130: e2003
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    Insights into centrosome-spindle coupling
    Journal of Cell Science 2017 130: e2004
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    Shedding light on integrin function in angiogenesis
    Journal of Cell Science 2017 130: e2005

FIRST PERSON

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    First person – Olivia Susanto
    Journal of Cell Science 2017 130: 3421-3422; doi: 10.1242/jcs.210872

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Mahak Sharma
    Journal of Cell Science 2017 130: 3423-3425; doi: 10.1242/jcs.209528

CELL SCIENCE AT A GLANCE

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    Actin assembly mechanisms at a glance
    Klemens Rottner, Jan Faix, Sven Bogdan, Stefan Linder, Eugen Kerkhoff
    Journal of Cell Science 2017 130: 3427-3435; doi: 10.1242/jcs.206433

    Summary: The morphological diversity and distinct dynamics of mammalian actin structures are established by coordinating the targeting and activation of actin filament nucleators, elongators and associated myosin motor proteins.

HYPOTHESIS

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    A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks
    Roy A. Quinlan, Nicole Schwarz, Reinhard Windoffer, Christine Richardson, Tim Hawkins, Joshua A. Broussard, Kathleen J. Green, Rudolf E. Leube
    Journal of Cell Science 2017 130: 3437-3445; doi: 10.1242/jcs.202168

    Summary: The cytoplasmic intermediate filament comprises a rim and spoke arrangement supporting the plasma membrane and connecting to the nucleus, to deliver their mechanosensory functions.

SHORT REPORT

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    Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome
    Philipp P. Prosseda, Na Luo, Biao Wang, Jorge A. Alvarado, Yang Hu, Yang Sun
    Journal of Cell Science 2017 130: 3447-3454; doi: 10.1242/jcs.200857

    Summary: Lack of OCRL elevates PI(4,5)P2 levels in primary cilia of human patient cells and cells from a mouse model of Lowe syndrome, supporting a role for OCRL in ciliary phosphoinositide regulation.

RESEARCH ARTICLES

  • Open Access
    LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
    Olivia Susanto, Yvette W. H. Koh, Nick Morrice, Sergey Tumanov, Peter A. Thomason, Matthew Nielson, Luke Tweedy, Andrew J. Muinonen-Martin, Jurre J. Kamphorst, Gillian M. Mackay, Robert H. Insall
    Journal of Cell Science 2017 130: 3455-3466; doi: 10.1242/jcs.207514

    Highlighted Article: Melanoma cells can create and follow their own gradients of attractant, via a new mechanism by which tumour cells may undergo metastasis.

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    A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking
    Gary B. O'Mealey, Kendra S. Plafker, William L. Berry, Ralf Janknecht, Jefferson Y. Chan, Scott M. Plafker
    Journal of Cell Science 2017 130: 3467-3480; doi: 10.1242/jcs.203216

    Summary: Mitochondria undergo retrograde trafficking in response to proteasome inhibition. Disruption of the mitochondrial PGAM5-KEAP1-Nrf2 complex leads to degradation of the mitochondrial GTPase Miro2 and inhibition of stress-induced mitochondrial trafficking.

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    The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing
    Stephanie R. Gillespie, Liana J. Tedesco, Lingyan Wang, Audrey M. Bernstein
    Journal of Cell Science 2017 130: 3481-3495; doi: 10.1242/jcs.204628

    Highlighted Article: The deubiquitylase USP10 regulates αv integrin protein levels, fibrotic markers and myofibroblast persistence in a wound. Ubiquitin-mediated pathways should thus be considered in the pathogenesis of fibrotic healing.

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    C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation
    Chuang Li, Qiongfang Peng, Xiao Wan, Haili Sun, Jun Tang
    Journal of Cell Science 2017 130: 3496-3506; doi: 10.1242/jcs.202879

    Summary: The formation of PML-NBs, important sub-nuclear protein structures, is differentially regulated by the unique C-terminal portion of each PML isoform.

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    Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function
    Cristian De Gregorio, Ricardo Delgado, Andrés Ibacache, Jimena Sierralta, Andrés Couve
    Journal of Cell Science 2017 130: 3507-3516; doi: 10.1242/jcs.201657

    Highlighted Article: Disruption of Drosophila motor neuron Atlastin produces locomotor defects, axonal trafficking disorganization and synaptic dysfunction, providing insights into the cellular and pathological roles of neuronal atlastin in human spastic paraplegias.

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    Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation
    Takafumi Ichikawa, Masahiro Kita, Tsubasa S. Matsui, Ayaka Ichikawa Nagasato, Tomohiko Araki, Shian-Huey Chiang, Takuhito Sezaki, Yasuhisa Kimura, Kazumitsu Ueda, Shinji Deguchi, Alan R. Saltiel, Noriyuki Kioka
    Journal of Cell Science 2017 130: 3517-3531; doi: 10.1242/jcs.200691

    Summary: Comparing the functions of vinexin family (SORBS) proteins reveals that vinexin-α and CAP regulate vinculin behavior depending on the stiffness of the extracellular matrix, while ArgBP2 plays a role in generating greater contractile forces.

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    Optogenetic interrogation of integrin αVβ3 function in endothelial cells
    Zhongji Liao, Ana Kasirer-Friede, Sanford J. Shattil
    Journal of Cell Science 2017 130: 3532-3541; doi: 10.1242/jcs.205203

    Highlighted Article: Optogenetics show that the interaction of kindlin-2 with β3 integrin and other binding partners supports endothelial cell functions relevant to angiogenesis, including sprouting and podosome formation.

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    LDL switches the LRP6 internalization route from flotillin dependent to clathrin dependent in hepatic cells
    Hideki Yamamoto, Daisuke Umeda, Shinji Matsumoto, Akira Kikuchi
    Journal of Cell Science 2017 130: 3542-3556; doi: 10.1242/jcs.202135

    Summary: LRP6 is transcytosed with Niemann–Pick C1-like 1 protein, which mediates cholesterol absorption from the bile, to the apical membrane of hepatic cells, and LDL alters LRP6 trafficking to the lysosome.

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    Sequential activities of Dynein, Mud and Asp in centrosome–spindle coupling maintain centrosome number upon mitosis
    Floris Bosveld, Anna Ainslie, Yohanns Bellaïche
    Journal of Cell Science 2017 130: 3557-3567; doi: 10.1242/jcs.201350

    Highlighted Article: Centrosomes are tightly coupled to the bipolar spindle. In Drosophila, Dynein and Mud initiate the centrosome–spindle coupling during prophase, whereas Asp is necessary to maintain it during metaphase.

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    Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos
    Miho Oka, Keisuke Hashimoto, Yoshifumi Yamaguchi, Shin-ichiro Saitoh, Yuki Sugiura, Yuji Motoi, Kurara Honda, Yorifumi Kikko, Shinya Ohata, Makoto Suematsu, Masayuki Miura, Kensuke Miyake, Toshiaki Katada, Kenji Kontani
    Journal of Cell Science 2017 130: 3568-3577; doi: 10.1242/jcs.200519

    Summary: The small GTPase Arl8b, known to be involved in lysosomal function, contributes to mouse embryonic growth by mediating lysosomal degradation of maternal proteins in the visceral yolk sac endoderm.

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    Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron
    Yandong Lai, Jin Li, Xiuying Li, Chunbin Zou
    Journal of Cell Science 2017 130: 3578-3587; doi: 10.1242/jcs.206904

    Summary: Bacteria-derived endotoxin LPS downregulates both the acetyltransferase p300 and the deacetylase Sirt1 to promote PRMT1 protein stability via an SCFFbxl17 E3 ligase-recognized acetydegron that augments bronchial epithelial cell overgrowth.

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    Association of FK506 binding proteins with RyR channels – effect of CLIC2 binding on sub-conductance opening and FKBP binding
    Spencer J. Richardson, Gregory A. Steele, Esther M. Gallant, Alexander Lam, Charles E. Schwartz, Philip G. Board, Marco G. Casarotto, Nicole A. Beard, Angela F. Dulhunty
    Journal of Cell Science 2017 130: 3588-3600; doi: 10.1242/jcs.204461

    Summary: FK506 binding proteins influence RyR gating and this contributes to excess Ca2+ release in the CLIC2 RyR channelopathy.

RETRACTION

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    Retraction: Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J. Cell. Sci. doi: 10.1242/102848
    Ahmed H. K. El-Hashash, Gianluca Turcatel, Saaket Varma, Mohamed Berika, Denise Al Alam, David Warburton
    Journal of Cell Science 2017 130: 3601 doi: 10.1242/jcs.211193
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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    The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

    Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
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  • Open Access

    Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

    Sarah O'Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong, Hayden Schneider, Wei Q. Shi, Stephen High
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