IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- Inflammasome activation and assembly at a glance
Summary: This article and accompanying poster provides an outline of the concepts in the assembly of inflammasomes and cell death by pyroptosis.
REVIEW
- Mind the (sr)GAP – roles of Slit–Robo GAPs in neurons, brains and beyond
Summary: A review of the functions of Slit–Robo GTPase-activating proteins (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes.
RESEARCH ARTICLES
- The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking
Highlighted Article: Here, we show that sensory receptor cargo promotes its intracellular progression by providing input to a specific Arf GEF to activate a cognate Arf directing transport to the cilia.
- ADF10 shapes the overall organization of apical actin filaments by promoting their turnover and ordering in pollen tubes
Summary: ADF10 is an important regulator in shaping the overall organization of apical actin filaments and acts by promoting filament turnover and ordering as well as limiting their length.
- The polymorphic proteins TgrB1 and TgrC1 function as a ligand–receptor pair in Dictyostelium allorecognition
Highlighted Article: Two polymorphic membrane proteins that mediate allorecognition in Dictyostelium function as a ligand–receptor pair and their binding activates a signaling mechanism that is required for cooperative aggregation and differentiation.
- E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine
Summary: Epithelial tissues should permit cell proliferation without losing their integrity for homeostasis. MT2-MMP protease cleaves E-cadherin at apical junctions, promoting regulated exit from quiescence in epithelial cells in the intestine.
- A checkpoint-independent mechanism delays entry into mitosis after UV irradiation
Highlighted Article: A S. pombe checkpoint-independent pathway delays activation of the mitotic CDK after UV irradiation through selective translational downregulation of the mitotic cyclin Cdc13.
- KIF13A mediates trafficking of influenza A virus ribonucleoproteins
Summary: The molecular motor KIF13A carries vesicles with influenza A RNA to be packaged into assembling virions, and positively influences localization of vRNPs and virus assembly.
- FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation
Highlighted Article: The degradation of post-mitotic midbodies is regulated by FYCO1. Without FYCO1, midbodies accumulate, allowing for changes in cell function.
- Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells
Summary: Dynein and EFF-1 have a non-autonomous function in patterning PVD dendrites in C. elegans through epidermal SAX-7.
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An interview with Derek Walsh
Professor Derek Walsh is the guest editor of our new special issue Cell Biology of Host-Pathogen Interactions. In an interview, Derek tells us about his work in the field of DNA viruses, the impact of the pandemic on virology and what his role as Guest Editor taught him.
How to improve your scientific writing
"If you are a scientist and you want to succeed, you must become a writer."
How do scientists become master storytellers? We called on our journal Editors, proofreaders and contributors to our community sites for their advice on how to improve your scientific writing.
Meet the preLighters: Jennifer Ann Black
Following the theme of our latest special issue, postdoc Jennifer Ann Black studies replication stress and genome plasticity in Leishmania in Professor Luiz Tosi’s lab in Sao Paolo. We caught up with Jenn (virtually) to hear about her relocation to Brazil mid-pandemic, her research on parasites and what she enjoys about ‘preLighting’.
In our special issue, Chandrakar et al. and Rosazza et al. present their latest work on Leishmania.
Mole – The Corona Files
“There are millions of people around the world who continue to believe that the Terrible Pandemic is a hoax.”
Mole continues to offer his wise words to researchers on how to manage during the COVID-19 pandemic.
JCS and COVID-19
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