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March, 2017; 130 (6)

IN THIS ISSUE

  • You have accessSubscription required
    Virus assembly within caveolae
    Journal of Cell Science 2017 130: e0601
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    RhoG helps to disassemble invadopodia in breast cancer
    Journal of Cell Science 2017 130: e0602
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    Rap1 orchestrates cytoskeletal remodelling at the immune synapse
    Journal of Cell Science 2017 130: e0603
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    New insights into VRAC composition and substrates
    Journal of Cell Science 2017 130: e0604
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    Rab8 endocytosis at dynamic cell protrusions
    Journal of Cell Science 2017 130: e0605

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Gaia Pigino
    Journal of Cell Science 2017 130: 1019-1020; doi: 10.1242/jcs.202184

CELL SCIENCE AT A GLANCE

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    Corneal epithelial stem cells and their niche at a glance
    Craig S. Nowell, Freddy Radtke
    Journal of Cell Science 2017 130: 1021-1025; doi: 10.1242/jcs.198119

    Summary: We summarise the role of the niche microenvironment in regulating corneal epithelial stem cells during homeostasis, repair and disease.

RESEARCH ARTICLES

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    Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC
    Hui You, Yamei Ge, Jian Zhang, Yizhi Cao, Jing Xing, Dongming Su, Yujie Huang, Min Li, Shen Qu, Fei Sun, Xiubin Liang
    Journal of Cell Science 2017 130: 1027-1036; doi: 10.1242/jcs.198242

    Summary: Derlin-1 binds to ENaC and promotes its ubiquitylation and degradation via ER-related degradation. The E3 ligase HUWE1 is required and adds K11-linked ubiquitin chains to ENaC prompting its degradation.

  • Open Access
    Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly
    Alexander Ludwig, Tra Huong Nguyen, Daniel Leong, Laxmi Iyer Ravi, Boon Huan Tan, Sara Sandin, Richard J. Sugrue
    Journal of Cell Science 2017 130: 1037-1050; doi: 10.1242/jcs.198853

    Highlighted Article: The assembly of respiratory syncytial virus occurs in caveolar membranes and caveolar coat components are incorporated into the viral envelope.

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    The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis
    Elena A. Minina, Salim Hossain Reza, Emilio Gutierrez-Beltran, Pernilla H. Elander, Peter V. Bozhkov, Panagiotis N. Moschou
    Journal of Cell Science 2017 130: 1051-1063; doi: 10.1242/jcs.196865

    Summary: The cohesin-loading complex is evolutionarily conserved across kingdoms. In plants, subunits of the complex are crucial for determining the distribution of auxin maxima and cell fate during embryogenesis.

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    A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
    Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata
    Journal of Cell Science 2017 130: 1064-1077; doi: 10.1242/jcs.195552

    Highlighted Article: We describe a novel signaling pathway involving SGEF, RhoG and paxillin phosphorylation, which functions in the regulation of invadopodia disassembly in breast cancer cells.

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    The Aurora-A–Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
    Jing Wang, Kumar Nikhil, Keith Viccaro, Lei Chang, Max Jacobsen, George Sandusky, Kavita Shah
    Journal of Cell Science 2017 130: 1078-1093; doi: 10.1242/jcs.196790

    Summary: We show that the AURKA–Twist1 axis regulates EMT, xenograft growth and drug resistance in pancreatic cancer. This is the first mechanism linking AURKA activity with tumor metastasis through Twist1.

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    The Rap1–cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse
    Jia C. Wang, Jeff Y.-J. Lee, Sonja Christian, May Dang-Lawson, Caitlin Pritchard, Spencer A. Freeman, Michael R. Gold
    Journal of Cell Science 2017 130: 1094-1109; doi: 10.1242/jcs.191858

    Highlighted Article: Consistent with its role as a central regulator of cell polarity, we show that the Rap1 GTPase controls polarization of the microtubule network towards the B cell immune synapse.

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    The T cell IFT20 interactome reveals new players in immune synapse assembly
    Donatella Galgano, Anna Onnis, Elisa Pappalardo, Federico Galvagni, Oreste Acuto, Cosima T. Baldari
    Journal of Cell Science 2017 130: 1110-1121; doi: 10.1242/jcs.200006

    Summary: An unbiased mass spectrometry-based analysis of the interactors of the intraflagellar transport protein IFT20 in T cells revealed new vesicular traffic-related regulators of immune synapse assembly.

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    Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels
    Darius Lutter, Florian Ullrich, Jennifer C. Lueck, Stefan Kempa, Thomas J. Jentsch
    Journal of Cell Science 2017 130: 1122-1133; doi: 10.1242/jcs.196253

    Highlighted Article: The ability of volume-regulated heteromeric VRAC channels to conduct organic compounds, including the neurotransmitters glutamate and GABA, depends on LRRC8D and LRRC8E subunits, and suggests new roles in transcellular signal transduction.

  • Open Access
    Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage
    Christopher Bot, Annika Pfeiffer, Fosco Giordano, Dharani E. Manjeera, Nico P. Dantuma, Lena Ström
    Journal of Cell Science 2017 130: 1134-1146; doi: 10.1242/jcs.197236

    Summary: Accumulation of NIPBL, the cohesin loader, at different types of DNA lesions occurs through independent mechanisms. This finding enhances our understanding of the highly dynamic roles for NIPBL in genome stability.

  • Open Access
    Endocytic turnover of Rab8 controls cell polarization
    Maite Vidal-Quadras, Mikkel R. Holst, Monika K. Francis, Elin Larsson, Mariam Hachimi, Wai-Lok Yau, Johan Peränen, Fernando Martín-Belmonte, Richard Lundmark
    Journal of Cell Science 2017 130: 1147-1157; doi: 10.1242/jcs.195420

    Highlighted Article: GRAF1 mediates inactivation and endocytic removal of Rab8 from cell surface protrusions, thereby facilitating dynamic adjustment of the polarity axis.

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    miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2
    Yan Zhang, Mei Yu, Minjia Dai, Chang Chen, Qi Tang, Wei Jing, Hang Wang, Weidong Tian
    Journal of Cell Science 2017 130: 1158-1168; doi: 10.1242/jcs.197764

    Summary: Exosome-like vesicles derived from adipose tissue promote adipogenesis through miR-450a-5p by targeting WISP2. This suggests that exosome-like vesicles can be involved in cell-to-cell communication during adipocyte differentiation.

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    Ypk1 and Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodeling after membrane stresses
    Riko Hatakeyama, Keiko Kono, Satoshi Yoshida
    Journal of Cell Science 2017 130: 1169-1178; doi: 10.1242/jcs.198382

    Summary: Yeast resists plasma membrane stress by maintaining the cortical localization of Rho GTPase through lipid remodeling mediated by Ypk kinase and flippase.

  • Open Access
    Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei
    Bernardo P. Moreira, Carol K. Fonseca, Tansy C. Hammarton, Munira M. A. Baqui
    Journal of Cell Science 2017 130: 1179-1193; doi: 10.1242/jcs.194308

    Summary: Functional characterization of the T. brucei giant protein FAZ10 reveals it has roles in flagellar attachment, nucleus and kinetoplast positioning and, uniquely for a FAZ protein, a direct role in cytokinesis.

CORRECTIONS

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    Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
    Michael A. Mandell, Ashish Jain, Suresh Kumar, Moriah J. Castleman, Tahira Anwar, Eeva-Liisa Eskelinen, Terje Johansen, Rytis Prekeris, Vojo Deretic
    Journal of Cell Science 2017 130: 1194 doi: 10.1242/jcs.202499
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    Correction: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance
    Anne-Pascale Bouin, Alexander Kyumurkov, Myriam Régent-Kloeckner, Anne-Sophie Ribba, Eva Faurobert, Henri-Noël Fournier, Ingrid Bourrin-Reynard, Sandra Manet-Dupé, Christiane Oddou, Martial Balland, Emmanuelle Planus, Corinne Albiges-Rizo
    Journal of Cell Science 2017 130: 1195 doi: 10.1242/jcs.202218

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Development

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      Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion
      Susan E. Doyle, Matthew C. Pahl, Karsten H. Siller, Lindsay Ardiff, Sarah E. Siegrist
      Journal of Cell Science 2017 130: e1.1 doi: 10.1242/jcs.203067
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      The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1
      Jun-yi Zhu, Amy Heidersbach, Irfan S. Kathiriya, Bayardo I. Garay, Kathryn N. Ivey, Deepak Srivastava, Zhe Han, Isabelle N. King
      Journal of Cell Science 2017 130: e1.2 doi: 10.1242/jcs.203083
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    Long-term segmentation-free assessment of head-flagellum movement and intracellular calcium in swimming human sperm

    G. Corkidi, P. Hernández-Herrera, F. Montoya, H. Gadêlha, A. Darszon
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    Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast

    Elizabeth Wood, Kazunori Kume, Francisco J. Navarro, Paul Nurse
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    Turgor-dependent and coronin-mediated F-actin dynamics drive septin disc-to-ring remodeling in the blast fungus

    Nawaraj Dulal, Audra Mae Rogers, Rinalda Proko, Baronger Dowell Bieger, Rohana Liyanage, Venkata Rao Krishnamurthi, Yong Wang, Martin John Egan
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    Ferroptosis induces membrane blebbing in placental trophoblasts

    Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, Claudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky
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    A region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the Drosophila egg

    Jennifer Michelle Potter-Birriel, Graydon B. Gonsalvez, William F. Marzluff
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