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May, 2018; 131 (10)

RESEARCH HIGHLIGHTS

  • You have accessSubscription required
    Wtip controls apical constriction during neurulation
    Journal of Cell Science 2018 131: e1001
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    A mitochondrial feedback on Ca2+ uptake for steroid production
    Journal of Cell Science 2018 131: e1002
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    DUB isoforms take different jobs
    Journal of Cell Science 2018 131: e1003
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    The SunRiSEs on a new method for single-cell monitoring of translation
    Journal of Cell Science 2018 131: e1004

FIRST PERSON

  • You have accessSubscription required
    First person – Rafael José Argüello
    Journal of Cell Science 2018 131: jcs220434 doi: 10.1242/jcs.220434 Published 31 May 2018
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    First person – Nancy Nader
    Journal of Cell Science 2018 131: jcs220368 doi: 10.1242/jcs.220368 Published 23 May 2018
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    First person – Yvonne Kschonsak
    Journal of Cell Science 2018 131: jcs219931 doi: 10.1242/jcs.219931 Published 21 May 2018
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    First person – Gergő Szanda
    Journal of Cell Science 2018 131: jcs219758 doi: 10.1242/jcs.219758 Published 16 May 2018
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    First person – Pawel Leznicki
    Journal of Cell Science 2018 131: jcs219741 doi: 10.1242/jcs.219741 Published 16 May 2018
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    First person – Chih-Wen Chu
    Journal of Cell Science 2018 131: jcs219725 doi: 10.1242/jcs.219725 Published 16 May 2018

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Guangshuo Ou
    Journal of Cell Science 2018 131: jcs218826 doi: 10.1242/jcs.218826 Published 30 May 2018

OPINION

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    The path to VICTORy – a beginner's guide to success using commercial research antibodies
    Simon L. Goodman
    Journal of Cell Science 2018 131: jcs216416 doi: 10.1242/jcs.216416 Published 15 May 2018

    Summary: Much anguish, talent, time and money are expended on cell biology using inadequately characterized commercial research antibodies, and this can lead to bad science. I summarize the situation and suggest accessible solutions.

REVIEW

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    How alternative splicing affects membrane-trafficking dynamics
    R. Eric Blue, Ennessa G. Curry, Nichlas M. Engels, Eunice Y. Lee, Jimena Giudice
    Journal of Cell Science 2018 131: jcs216465 doi: 10.1242/jcs.216465 Published 16 May 2018

    Summary: This Review summarizes how trafficking is molecularly influenced by alternative splicing and how this interplay impacts physiology and pathological conditions.

SHORT REPORTS

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    A systematic survey of conformational states in β1 and β4 integrins using negative-stain electron microscopy
    Naoyuki Miyazaki, Kenji Iwasaki, Junichi Takagi
    Journal of Cell Science 2018 131: jcs216754 doi: 10.1242/jcs.216754 Published 22 May 2018

    Summary: A systematic structural analysis using negative-stain electron microscopy on many different β1 and β4 integrins showed no large ‘switchblade-like’ conformational change coupled to their affinity states.

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    Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling
    Victoria H. Ng, Brian I. Hang, Leah M. Sawyer, Leif R. Neitzel, Emily E. Crispi, Kristie L. Rose, Tessa M. Popay, Alison Zhong, Laura A. Lee, William P. Tansey, Stacey Huppert, Ethan Lee
    Journal of Cell Science 2018 131: jcs210575 doi: 10.1242/jcs.210575 Published 22 May 2018

    Summary: Threonine 180 is a critical site on XIAP that directs the activity of XIAP in Wnt signaling, but not apoptosis, allowing for the possibility of designing Wnt-specific therapeutics that target this site.

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    The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER
    Daniela G. Vitali, Monika Sinzel, Elianne P. Bulthuis, Antonia Kolb, Susanne Zabel, Dietmar G. Mehlhorn, Bruna Figueiredo Costa, Ákos Farkas, Anne Clancy, Maya Schuldiner, Christopher Grefen, Blanche Schwappach, Nica Borgese, Doron Rapaport
    Journal of Cell Science 2018 131: jcs211110 doi: 10.1242/jcs.211110 Published 16 May 2018

    Summary: The GET machinery can, in principle, process mitochondrial proteins but, under normal conditions, active mitochondrial targeting pathways dominate the kinetic competition against GET recognition.

RESEARCH ARTICLES

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    Multiple roles of epithelial heparan sulfate in stomach morphogenesis
    Meina Huang, Hua He, Tatyana Belenkaya, Xinhua Lin
    Journal of Cell Science 2018 131: jcs210781 doi: 10.1242/jcs.210781 Published 29 May 2018

    Summary: Heparan sulfate is highly expressed in the embryonic mammalian stomach and is required for gastric development, including stratification of forestomach and specification of glandular stomach.

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    BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia
    Irina Raykhel, Fazeh Moafi, Satu M. Myllymäki, Patricia G. Greciano, Karl S. Matlin, Jose V. Moyano, Aki Manninen, Johanna Myllyharju
    Journal of Cell Science 2018 131: jcs210906 doi: 10.1242/jcs.210906 Published 23 May 2018

    Summary: Hypoxia disrupts the polarity of MDCK cysts in a HIF1α-dependent manner by modulating the TGFβ pathway. BAMBI is identified as a novel HIF1-regulated gene that contributes to the hypoxia-induced polarity defect.

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    The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling
    Nancy Nader, Maya Dib, Raphael Courjaret, Rawad Hodeify, Raya Machaca, Johannes Graumann, Khaled Machaca
    Journal of Cell Science 2018 131: jcs212522 doi: 10.1242/jcs.212522 Published 23 May 2018

    Summary: VLDLR is a chaperone important for membrane progesterone receptor (mPR) trafficking and is required for non-genomic progesterone signaling.

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    14-3-3 proteins regulate desmosomal adhesion via plakophilins
    Katrin Rietscher, René Keil, Annemarie Jordan, Mechthild Hatzfeld
    Journal of Cell Science 2018 131: jcs212191 doi: 10.1242/jcs.212191 Published 22 May 2018

    Summary: Growth factor signaling regulates the phosphorylation-dependent association of plakophilins 1 and 3 with 14-3-3 isoforms, revealing partially antagonistic functions of 14-3-3 proteins in the regulation of desmosomes.

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    Activated ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation
    Yvonne T. Kschonsak, Ingrid Hoffmann
    Journal of Cell Science 2018 131: jcs214544 doi: 10.1242/jcs.214544 Published 21 May 2018

    Summary: Activated ezrin controls cortical MISP levels, which are necessary for proper NuMA polarization at the cortex and, hence, precise spindle orientation.

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    Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
    Christopher H. Choy, Golam Saffi, Matthew A. Gray, Callen Wallace, Roya M. Dayam, Zhen-Yi A. Ou, Guy Lenk, Rosa Puertollano, Simon C. Watkins, Roberto J. Botelho
    Journal of Cell Science 2018 131: jcs213587 doi: 10.1242/jcs.213587 Published 21 May 2018

    Summary: PIKfyve inhibition causes lysosomes to coalesce, resulting in fewer, enlarged lysosomes; TFEB-mediated lysosome biosynthesis does not contribute to swelling.

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    Expansion of DUB functionality generated by alternative isoforms – USP35, a case study
    Pawel Leznicki, Jayaprakash Natarajan, Gerd Bader, Walter Spevak, Andreas Schlattl, Syed Arif Abdul Rehman, Deepika Pathak, Simone Weidlich, Andreas Zoephel, Marie C. Bordone, Nuno L. Barbosa-Morais, Guido Boehmelt, Yogesh Kulathu
    Journal of Cell Science 2018 131: jcs212753 doi: 10.1242/jcs.212753 Published 16 May 2018

    Highlighted Article: An analysis of USP35 shows that alternative isoforms can substantially contribute to expanding the functionality of deubiquitylating enzymes, hence allowing them to regulate multiple intracellular ubiquitylation events.

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    Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
    Fiona N. Kenny, Zoe Drymoussi, Robin Delaine-Smith, Alexander P. Kao, Ana C. Laly, Martin M. Knight, Michael P. Philpott, John T. Connelly
    Journal of Cell Science 2018 131: jcs215780 doi: 10.1242/jcs.215780 Published 16 May 2018

    Summary: Increased matrix stiffness promotes keratinocyte proliferation through activation of the epidermal growth factor receptor both in vitro and in keloid scars.

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    Mitochondrial cAMP exerts positive feedback on mitochondrial Ca2+ uptake via the recruitment of Epac1
    Gergő Szanda, Éva Wisniewski, Anikó Rajki, András Spät
    Journal of Cell Science 2018 131: jcs215178 doi: 10.1242/jcs.215178 Published 16 May 2018

    Highlighted Article: The Ca2+-dependent formation of mitochondrial cAMP by matrix-localized soluble adenylyl cyclase intensifies further Ca2+ uptake into the organelle; this convergence of signalling pathways supports steroidogenesis.

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    The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure
    Chih-Wen Chu, Bo Xiang, Olga Ossipova, Andriani Ioannou, Sergei Y. Sokol
    Journal of Cell Science 2018 131: jcs213884 doi: 10.1242/jcs.213884 Published 16 May 2018

    Highlighted Article: Wtip is a tension-sensitive cytoskeletal adaptor that binds Shroom3 and modulates Shroom3-dependent apical constriction during Xenopus neurulation.

TOOLS AND RESOURCES

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    SunRiSE – measuring translation elongation at single-cell resolution by means of flow cytometry
    Rafael J. Argüello, Marisa Reverendo, Andreia Mendes, Voahirana Camosseto, Adrian G. Torres, Lluis Ribas de Pouplana, Serge A. van de Pavert, Evelina Gatti, Philippe Pierre
    Journal of Cell Science 2018 131: jcs214346 doi: 10.1242/jcs.214346 Published 31 May 2018

    Highlighted Article: A novel method to measure translation elongation rate and intensity in complex and heterogeneous cell populations by combining puromycilation, translation run-off experiment and flow cytometry detection is presented.

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    Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing
    Florian A. Gegenfurtner, Berenice Jahn, Helga Wagner, Christoph Ziegenhain, Wolfgang Enard, Ludwig Geistlinger, Joachim O. Rädler, Angelika M. Vollmar, Stefan Zahler
    Journal of Cell Science 2018 131: jcs212886 doi: 10.1242/jcs.212886 Published 29 May 2018

    Summary: A specifically tailored set of micropatterns is used as a cell biological tool to study the regulation of mechanosensitive transcription factors in an angiogenesis model.

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    RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation
    Raymond S. Oh, Andrew J. Haak, Karry M. J. Smith, Giovanni Ligresti, Kyoung Moo Choi, Tiao Xie, Shaohua Wang, Paula R. Walters, Michael A. Thompson, Michelle R. Freeman, Logan J. Manlove, Vivian M. Chu, Carol Feghali-Bostwick, Anja C. Roden, Jürgen Schymeinsky, Christina M. Pabelick, Y. S. Prakash, Robert Vassallo, Daniel J. Tschumperlin
    Journal of Cell Science 2018 131: jcs209932 doi: 10.1242/jcs.209932 Published 15 May 2018

    Summary: Myofibroblasts are key drivers of fibrosis. Here, RNAi screening is used to identify novel regulators of myofibroblast activation, and a matrix-stiffness-dependent STAT3 activation pathway is identified.

CORRECTIONS

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    Correction: Distance-dependent cellular palmitoylation of de-novo-designed sequences and their translocation to plasma membrane subdomains (J. Cell Sci. 115, 3119-3130)
    Inmaculada Navarro-Lérida, Alberto Álvarez-Barrientos, Francisco Gavilanes, Ignacio Rodríguez-Crespo
    Journal of Cell Science 2018 131: jcs219634 doi: 10.1242/jcs.219634 Published 4 June 2018
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    Correction: Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels (doi:10.1242/jcs.01002)
    Inmaculada Navarro-Lérida, María Teresa Portolés, Alberto Álvarez Barrientos, Francisco Gavilanes, Lisardo Boscá, Ignacio Rodríguez-Crespo
    Journal of Cell Science 2018 131: jcs219667 doi: 10.1242/jcs.219667 Published 4 June 2018
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    Correction: N-terminal palmitoylation within the appropriate amino acid environment conveys on NOS2 the ability to progress along the intracellular sorting pathways (doi:10.1242/jcs.02878)
    Inmaculada Navarro-Lérida, Alberto Álvarez-Barrientos, Ignacio Rodríguez-Crespo
    Journal of Cell Science 2018 131: jcs219675 doi: 10.1242/jcs.219675 Published 4 June 2018
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    Correction: Protein kinase D activity controls endothelial nitric oxide synthesis (doi:10.1242/jcs.148601)
    Clara Aicart-Ramos, Lucía Sánchez-Ruiloba, Mónica Gómez-Parrizas, Carlos Zaragoza, Teresa Iglesias, Ignacio Rodríguez-Crespo
    Journal of Cell Science 2018 131: jcs219683 doi: 10.1242/jcs.219683 Published 4 June 2018
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    SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72

    Mirjana Malnar, Boris Rogelj
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    Calcium elevations disrupt interactions between intraflagellar transport and the flagella membrane in Chlamydomonas

    Cecile Fort, Peter Collingridge, Colin Brownlee, Glen Wheeler
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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