RESEARCH HIGHLIGHT
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEW
- Autophagy-dependent cell death – where, how and why a cell eats itself to death
Summary: A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagy a lethal process.
- Failure is not an option – mitochondrial genome segregation in trypanosomes
Summary: This Review discusses recent discoveries regarding the unusual segregation system of the single-unit mitochondrial genome of T. brucei.
SHORT REPORT
- The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus
Summary: Nuclear functions of mammalian EGF receptors contribute to cancer. Here, we show that such functions are not conserved in the invertebrate Drosophila.
RESEARCH ARTICLES
- The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Summary: The leukotriene B4–BLT1 axis regulates the polarized trafficking of the chemoattractant receptors FPR1 and C5aR1 from the trailing edge of polarized neutrophils, to drive persistent chemotaxis.
- LRRC45 contributes to early steps of axoneme extension
Summary: LRRC45 at distal appendages is required for early steps of axoneme extension by promoting transition zone establishment, Rab8a recruitment and satellite organisation.
- Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription
Summary: In nitrogen-poor medium, inhibition of Cdk1 becomes essential for generating a proper wave of MBF-dependent transcription at G1/S, which prevents DNA replication stress.
- Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles
Summary: Rab4A controls cargo segregation by forming a complex with rabenosyn-5, KIF3 and AP-3 on sorting endosomes to divert the cargo toward melanosomes.
- LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
Highlighted Article: Embryonic stem cells rely upon expression of a novel lipid-modified Gab1 adaptor protein to promote survival under nutrient-poor conditions.
- Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin
Highlighted Article: Nuclei are highly branched throughout the heterogeneous population of healthy epidermal cells in the Xenopus tail fin periphery, and disruption of nuclear branching results in improper fin morphology.
- Neurodegeneration and locomotor dysfunction in Drosophila scarlet mutants
Highlighted Article: Drosophila scarlet mutants show progressive loss of dopaminergic neurons, along with locomotor impairments, and Scarlet has a neuroprotective role in a Parkinson's disease model.
This issue
JUMP TO
Other journals from The Company of Biologists
2020 at The Company of Biologists
Despite the challenges of 2020, we were able to bring a number of long-term projects and new ventures to fruition. While we look forward to a new year, join us as we reflect on the triumphs of the last 12 months.
Mole – The Corona Files
"This is not going to go away, 'like a miracle.' We have to do magic. And I know we can."
Mole continues to offer his wise words to researchers on how to manage during the COVID-19 pandemic.
Cell scientist to watch – Christine Faulkner
In an interview, Christine Faulkner talks about where her interest in plant science began, how she found the transition between Australia and the UK, and shares her thoughts on virtual conferences.
Read & Publish participation extends worldwide
“The clear advantages are rapid and efficient exposure and easy access to my article around the world. I believe it is great to have this publishing option in fast-growing fields in biomedical research.”
Dr Jaceques Behmoaras (Imperial College London) shares his experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 60 institutions in 12 countries taking part – find out more and view our full list of participating institutions.
JCS and COVID-19
For more information on measures Journal of Cell Science is taking to support the community during the COVID-19 pandemic, please see here.
If you have any questions or concerns, please do not hestiate to contact the Editorial Office.