RESEARCH HIGHLIGHT
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEW
- Autophagy-dependent cell death – where, how and why a cell eats itself to death
Summary: A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagy a lethal process.
- Failure is not an option – mitochondrial genome segregation in trypanosomes
Summary: This Review discusses recent discoveries regarding the unusual segregation system of the single-unit mitochondrial genome of T. brucei.
SHORT REPORT
- The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus
Summary: Nuclear functions of mammalian EGF receptors contribute to cancer. Here, we show that such functions are not conserved in the invertebrate Drosophila.
RESEARCH ARTICLES
- The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Summary: The leukotriene B4–BLT1 axis regulates the polarized trafficking of the chemoattractant receptors FPR1 and C5aR1 from the trailing edge of polarized neutrophils, to drive persistent chemotaxis.
- LRRC45 contributes to early steps of axoneme extension
Summary: LRRC45 at distal appendages is required for early steps of axoneme extension by promoting transition zone establishment, Rab8a recruitment and satellite organisation.
- Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription
Summary: In nitrogen-poor medium, inhibition of Cdk1 becomes essential for generating a proper wave of MBF-dependent transcription at G1/S, which prevents DNA replication stress.
- Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles
Summary: Rab4A controls cargo segregation by forming a complex with rabenosyn-5, KIF3 and AP-3 on sorting endosomes to divert the cargo toward melanosomes.
- LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
Highlighted Article: Embryonic stem cells rely upon expression of a novel lipid-modified Gab1 adaptor protein to promote survival under nutrient-poor conditions.
- Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin
Highlighted Article: Nuclei are highly branched throughout the heterogeneous population of healthy epidermal cells in the Xenopus tail fin periphery, and disruption of nuclear branching results in improper fin morphology.
- Neurodegeneration and locomotor dysfunction in Drosophila scarlet mutants
Highlighted Article: Drosophila scarlet mutants show progressive loss of dopaminergic neurons, along with locomotor impairments, and Scarlet has a neuroprotective role in a Parkinson's disease model.
This issue
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Other journals from The Company of Biologists
Review - Mechanics of nuclear membranes
Ashutosh Agrawal and Tanmay Lele review literature providing quantitative insights into nuclear membrane mechanics and its importance in envelope function.
Journal of Cell Science announces Transparent peer review
In the interests of promoting transparency around the editorial process, Journal of Cell Science will now be publishing a ‘Peer review history’ file alongside published papers, where the author has opted in to such a file being published. All research papers submitted on or after 1 August 2019 are eligible. More information can be found here.
First Person interviews
Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Carlos Alonso, Aryeh Babkoff, Andrew Porter and Yohan Kim.
Journal of Cell Science partners with Publons for peer reviewer recognition
Journal of Cell Science is pleased to announce a new partnership with Publons, part of the Web of Science Group (a Clarivate Analytics company). Publons gives reviewers formal recognition of their peer review contributions using the Reviewer Recognition Service.
Mole - Wouldn't it, too, be nice?
“Maybe, when we review, we might put ourselves into the authors' place (where we have all been) and point out the good along with the ‘bad’ (not to mention, ‘ugly’).”
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Extended submission deadline: 15 August 2019.
preLights - A unified role for membrane-cortex detachment during cell protrusion initiation
Martim Dias Gomes highlights a preprint showing that membrane-cortex detachment is essential for the formation of both pressure- and actin-based protrusions.
Catch up with other recent preLights selected for the cell science community.
Data Science in Cell Imaging Workshop - Early-career researcher places available
Apply until 16 August 2019 for a funded early-career researcher place to attend our Workshop, which will be held at beautiful Wiston house.
Articles of interest in our sister journals
Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation
Adrià Voltes, Covadonga F. Hevia, Carolyn Engel-Pizcueta, Chaitanya Dingare, Simone Calzolari, Javier Terriente, Caren Norden, Virginie Lecaudey, Cristina Pujades
Development 2019 146: dev176735
The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development
Gabriel A. Leung, Taylor Cool, Clint H. Valencia, Atesh Worthington, Anna E. Beaudin, E. Camilla Forsberg
Development 2019 146: dev176180