RESEARCH HIGHLIGHT
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEW
- Autophagy-dependent cell death – where, how and why a cell eats itself to death
Summary: A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagy a lethal process.
- Failure is not an option – mitochondrial genome segregation in trypanosomes
Summary: This Review discusses recent discoveries regarding the unusual segregation system of the single-unit mitochondrial genome of T. brucei.
SHORT REPORT
- The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus
Summary: Nuclear functions of mammalian EGF receptors contribute to cancer. Here, we show that such functions are not conserved in the invertebrate Drosophila.
RESEARCH ARTICLES
- The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Summary: The leukotriene B4–BLT1 axis regulates the polarized trafficking of the chemoattractant receptors FPR1 and C5aR1 from the trailing edge of polarized neutrophils, to drive persistent chemotaxis.
- LRRC45 contributes to early steps of axoneme extension
Summary: LRRC45 at distal appendages is required for early steps of axoneme extension by promoting transition zone establishment, Rab8a recruitment and satellite organisation.
- Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription
Summary: In nitrogen-poor medium, inhibition of Cdk1 becomes essential for generating a proper wave of MBF-dependent transcription at G1/S, which prevents DNA replication stress.
- Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles
Summary: Rab4A controls cargo segregation by forming a complex with rabenosyn-5, KIF3 and AP-3 on sorting endosomes to divert the cargo toward melanosomes.
- LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
Highlighted Article: Embryonic stem cells rely upon expression of a novel lipid-modified Gab1 adaptor protein to promote survival under nutrient-poor conditions.
- Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin
Highlighted Article: Nuclei are highly branched throughout the heterogeneous population of healthy epidermal cells in the Xenopus tail fin periphery, and disruption of nuclear branching results in improper fin morphology.
- Neurodegeneration and locomotor dysfunction in Drosophila scarlet mutants
Highlighted Article: Drosophila scarlet mutants show progressive loss of dopaminergic neurons, along with locomotor impairments, and Scarlet has a neuroprotective role in a Parkinson's disease model.
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Cell scientist to watch – Adrian Saurin
Adrian Saurin is a group leader at the University of Dundee, where he studies the spatial regulation of mitotic signalling networks with the support of a Cancer Research UK (CRUK) Programme Foundation Award. He talks about the winding path to a setting up his own group, his research program and much more.
Catch up with early-career first authors in our First Person interviews. Recently, we spoke to Shelby Bearrows, Javier Coy-Vergara, Anne Schaar, Nina Short and Max Butler.
Dina Coelho and Eduardo Moreno give an introduction to the molecular mechanisms of cell competition, and the biological relevance of competition in the nervous system in the context of Alzheimer’s disease.
Review - New insights into extracellular vesicle biogenesis and function
Marc Antonyak and colleagues highlight some of the recent findings regarding the roles of extracellular vesicles in physiological and pathological processes.
Mole - Wouldn't it be nice?
“Show some courtesy; do not simply decide that everything around you is yours. It's just rude. Wouldn't it be nice if people asked permission before they photographed your poster or presentation?”
Meet the Team
Journal of Cell Science Editors are going to be out and about in July.
Meet Senior Editor Petra Gross at the 2nd Mechanobiology meeting in Vietnam, Executive Editor Sharon Ahmad at the GRC Molecular membrane biology conference and Editor in Chief Michael Way and Reviews Editor Manuel Breuer at the GRC Motile and contractile systems conference.
New manuscript transfer network between JCS, JCB and MBoC
Journal of Cell Science (JCS), Journal of Cell Biology (JCB) and Molecular Biology of the Cell (MBoC) announce a new manuscript transfer option that will empower authors whose manuscripts have been declined to seamlessly transfer their manuscripts and associated peer review reports between the journals.
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Extended submission deadline: 15 August 2019.
preLights - Cytoskeletal tension actively sustains the migratory T cell synaptic contact
Tim Fessenden highlights a preprint from Darrel Irvine and team who reveal that actin foci establish a tensile network which sustains the immunological synapse formed during T cell activation.
Catch up with other recent preLights selected for the cell science community.
Data Science in Cell Imaging Workshop - Early-career researcher places available
Apply until 16 August 2019 for a funded early-career researcher place to attend our Workshop, which will be held at beautiful Wiston house.
Articles of interest in our sister journals
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
Ying Mao, Renjun Tu, Yan Huang, Decai Mao, Zhihao Yang, Pik Ki Lau, Jinhui Wang, Jianquan Ni, Yusong Guo, Ting Xie
Development 2019 146: dev174615
Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in vivo
Daniel B. Lybrand, Misha Naiman, Jessie May Laumann, Mitzi Boardman, Samuel Petshow, Kevin Hansen, Gregory Scott, Marcel Wehrli
Development 2019 146: dev164145