RESEARCH HIGHLIGHT
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEW
- Autophagy-dependent cell death – where, how and why a cell eats itself to death
Summary: A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagy a lethal process.
- Failure is not an option – mitochondrial genome segregation in trypanosomes
Summary: This Review discusses recent discoveries regarding the unusual segregation system of the single-unit mitochondrial genome of T. brucei.
SHORT REPORT
- The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus
Summary: Nuclear functions of mammalian EGF receptors contribute to cancer. Here, we show that such functions are not conserved in the invertebrate Drosophila.
RESEARCH ARTICLES
- The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Summary: The leukotriene B4–BLT1 axis regulates the polarized trafficking of the chemoattractant receptors FPR1 and C5aR1 from the trailing edge of polarized neutrophils, to drive persistent chemotaxis.
- LRRC45 contributes to early steps of axoneme extension
Summary: LRRC45 at distal appendages is required for early steps of axoneme extension by promoting transition zone establishment, Rab8a recruitment and satellite organisation.
- Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription
Summary: In nitrogen-poor medium, inhibition of Cdk1 becomes essential for generating a proper wave of MBF-dependent transcription at G1/S, which prevents DNA replication stress.
- Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles
Summary: Rab4A controls cargo segregation by forming a complex with rabenosyn-5, KIF3 and AP-3 on sorting endosomes to divert the cargo toward melanosomes.
- LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
Highlighted Article: Embryonic stem cells rely upon expression of a novel lipid-modified Gab1 adaptor protein to promote survival under nutrient-poor conditions.
- Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin
Highlighted Article: Nuclei are highly branched throughout the heterogeneous population of healthy epidermal cells in the Xenopus tail fin periphery, and disruption of nuclear branching results in improper fin morphology.
- Neurodegeneration and locomotor dysfunction in Drosophila scarlet mutants
Highlighted Article: Drosophila scarlet mutants show progressive loss of dopaminergic neurons, along with locomotor impairments, and Scarlet has a neuroprotective role in a Parkinson's disease model.
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JCS and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Ricardo Henriques introduces FocalPlane
FocalPlane Scientific Advisory Board member Ricardo Henriques (University College London) gives a brief introduction to our upcoming microscopy community site. Follow us on Twitter @focalplane_jcs or sign up for the latest launch updates.
The Corona Files
“…if there is one thing that is achingly, chillingly clear, if it wasn't already, is that this thing we do is really, really important.”
Our resident insectivore, Mole, has started a new series – The Corona Files. Follow Mole’s weekly musings on how COVID-19 is changing the landscape for researchers.
Do you have an idea for a Workshop?
Our Workshop programme may be on hold for now, but we are welcoming ideas for the 2022 line-up. The proposal deadline is 29 May 2020, so find out how to pitch your idea to the Workshop Committee in good time.
Call for papers: Cell Biology of Host-Pathogen Interactions
Showcase your breakthrough research on all aspects of cell biology relating to host-pathogen interactions for our upcoming Special Issue. Articles must be received by 30 July 2020 for consideration. Find out more about the scope, publication schedule and how to submit your manuscript.