Transient intracellular acidification regulates the core transcriptional heat shock response by Triandafillou et al.
A short-lived decrease in the pH of the cellular interior is critical to mount a response to environmental stresses such as increased temperature.
Selected by Srivats Venkataramanan. Read the preLight here
Budding yeast complete DNA replication after chromosome segregation begins by Ivanova et al.
Procrastinating polymerases: Budding yeast postpone the replication of tricky DNA sequences until anaphase.
Selected by Gautam Dey and Maiko Kitaoka. Read the preLight here
Protein Kinase A activity is regulated by actomyosin contractility during cell migration and is required for durotaxis by McKenzie et al.
Following the stiffness gradient and need a guide? PKA activity lights the way through mechanically regulated activity in the leading cell edge that is necessary for efficient durotaxis.
Selected by Amanda Haage. Read the preLight here
Synergy with TGFβ ligands switches WNT pathway dynamics from transient to sustained during human pluripotent cell differentiation by Massey et al.
Two faces of the same coin: WNT and TGFβ signalling synergy for β-Catenin activation.
Selected by Pierre Osteil. Read the preLight here
Eukaryotic acquisition of a bacterial operon by Kominek et al.
A HOT finding: iron uptake by budding yeast made possible through horizontal transfer of a bacterial operon.
Selected by Lauren Neves. Read the preLight here
SABER enables highly multiplexed and amplified detection of DNA and RNA in cells and tissues by Kishi et al.
Utilizing strand displacing polymerases, Kishi et al. forged SABER to enable a faster, more sensitive, and cheaper protocol of fluorescence in situ hybridization.
Selected by Yen-Chung Chen. Read the preLight here
Agrobacterium tumefaciens divisome proteins regulate the transition from polar growth to cell division by Howell et al.
No matter whether polar or lateral growth, FtsZ rings drive the assembly of the divisome to coordinate bacterial cell division.
Selected by Hannah Behrens. Read the preLight here
Raincloud plots: a multi-platform tool for robust data visualization by Allen et al.
Let it rain! Using raincloud plots to better visualise data.
Selected by Samantha Seah. Read the preLight here
PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection by Buckley et al.
A battle for survival: PIKfyve ensures phagosome maturation, enhancing professional phagocyte ability to effectively kill bacteria.
Selected by Giuliana Clemente. Read the preLight here
Target-specific precision of CRISPR-mediated genome editing by Chakrabarti et al.
The predictability of genome editing outcome varies across target sites and primarily depends on the nucleotide in the -4 position from the PAM site. Careful selection of target site is therefore key to inducing a specific desired modification.
Selected by Rob Hynds. Read the preLight here
3D Tissue elongation via ECM stiffness-cued junctional remodeling by Chen et al.
A mechanochemical pathway drives tissue elongation in edgeless epithelia.
Selected by Sundar Naganathan. Read the preLight here
STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway by Swoboda et al.
Switching melanoma behaviour with STAT3: STAT3 represses the MITF pathway to drive metastasis
Selected by Hannah Brunsdon. Read the preLight here
- © 2018. Published by The Company of Biologists Ltd
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