RESEARCH HIGHLIGHTS
FIRST PERSON
REVIEW
- Endocytosis in proliferating, quiescent and terminally differentiated cells
Summary: Studies on endocytosis usually use transformed cells, but the majority of cells in an adult organism have exited the cell cycle. Here, we review endocytosis in dividing, quiescent and terminally differentiated cells.
SHORT REPORTS
- Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair
Summary: TRF2 is recruited to DNA double-strand break damage sites through a two-step mechanism and functions in non-sister chromatid homologous recombination repair.
- Cytokine exocytosis and JAK/STAT activation in the Drosophila ovary requires the vesicle trafficking regulator α-Snap
Summary: The vesicle trafficking regulator α-Snap acts upstream of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway to induce motile cell fate during oogenesis.
RESEARCH ARTICLES
- Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis
Summary: Eukaryotic chemotaxis and pseudopod dynamics are mediated by cGMP and PIP3 signaling pathways, which show characteristic features of excitability and refractoriness.
- Role of G-proteins and phosphorylation in the distribution of AGS3 to cell puncta
Summary: A single threonine residue in the G-protein regulatory domain of AGS3 is a determinant factor in the oscillation of AGS3 among different subcellular compartments and protein phase transitions.
- Elongated mitochondrial constrictions and fission in muscle fatigue
Highlighted Article: Exercise and electrical stimulation increase the frequency of elongated mitochondrial constrictions, providing novel structural evidence for mitochondrial dynamics stages in mouse fast-twitch muscle fibers.
- CAP1-mediated actin cycling via ADF/cofilin proteins is essential for asymmetric division in mouse oocytes
Summary: CAP1 is shown to regulate the ADF/cofilin protein family that mediates dynamic actin recycling in mouse oocytes.
- CCDC102B functions in centrosome linker assembly and centrosome cohesion
Summary: CCDC102B, a protein whose function was previously unknown, is essential for centrosome cohesion and facilitates the filament formation of rootletin.
- Localization of all four ZnT zinc transporters in Dictyostelium and impact of ZntA and ZntB knockout on bacteria killing
Highlighted Article: Metal poisoning is one of the bactericidal strategies of macrophages. Here, we describe the dynamics of free Zn2+ and the role of Zn2+ transporters during phagocytosis in Dictyostelium.
- Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells
Summary: Autophagy dynamics of microglial cells stimulated with the neuropathogenic protein alpha-synuclein (AS) show that autophagy is activated as a response to control AS-induced lysosomal damage.
- Tropomyosin 3.5 protects the F-actin networks required for tissue biomechanical properties
Highlighted Article: Tropomyosin 3.5 stabilizes F-actin in eye lens fiber cells and promotes normal tissue biomechanical properties. Tpm3.5 deficiency leads to F-actin network rearrangements and decreased lens stiffness and resilience.
- Soluble α-synuclein facilitates priming and fusion by releasing Ca2+ from the thapsigargin-sensitive Ca2+ pool in PC12 cells
Summary: α-Synuclein and the Rab3A–Munc13-1–Munc18-1 act on the same population of vesicles to enhance exocytosis via different pathways, and α-synuclein activates Ca2+ release to enhance priming and fusion.
- Hepatocyte-like cells reveal novel role of SERPINA1 in transthyretin amyloidosis
Summary: Several chaperone genes are differently expressed in ATTR-derived hepatocyte-like cells and SERPINA1 might interfere with TTR aggregation.
This issue
Other journals from The Company of Biologists
Review - Mechanics of nuclear membranes
Ashutosh Agrawal and Tanmay Lele review literature providing quantitative insights into nuclear membrane mechanics and its importance in envelope function.
Journal of Cell Science announces Transparent peer review
In the interests of promoting transparency around the editorial process, Journal of Cell Science will now be publishing a ‘Peer review history’ file alongside published papers, where the author has opted in to such a file being published. All research papers submitted on or after 1 August 2019 are eligible. More information can be found here.
First Person interviews
Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Carlos Alonso, Aryeh Babkoff, Andrew Porter and Yohan Kim.
Journal of Cell Science partners with Publons for peer reviewer recognition
Journal of Cell Science is pleased to announce a new partnership with Publons, part of the Web of Science Group (a Clarivate Analytics company). Publons gives reviewers formal recognition of their peer review contributions using the Reviewer Recognition Service.
Mole - Wouldn't it, too, be nice?
“Maybe, when we review, we might put ourselves into the authors' place (where we have all been) and point out the good along with the ‘bad’ (not to mention, ‘ugly’).”
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Extended submission deadline: 15 August 2019.
preLights - A unified role for membrane-cortex detachment during cell protrusion initiation
Martim Dias Gomes highlights a preprint showing that membrane-cortex detachment is essential for the formation of both pressure- and actin-based protrusions.
Catch up with other recent preLights selected for the cell science community.
Data Science in Cell Imaging Workshop - Early-career researcher places available
Apply until 16 August 2019 for a funded early-career researcher place to attend our Workshop, which will be held at beautiful Wiston house.
Articles of interest in our sister journals
Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation
Adrià Voltes, Covadonga F. Hevia, Carolyn Engel-Pizcueta, Chaitanya Dingare, Simone Calzolari, Javier Terriente, Caren Norden, Virginie Lecaudey, Cristina Pujades
Development 2019 146: dev176735
The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development
Gabriel A. Leung, Taylor Cool, Clint H. Valencia, Atesh Worthington, Anna E. Beaudin, E. Camilla Forsberg
Development 2019 146: dev176180