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May, 2019; 132 (10)

RESEARCH HIGHLIGHTS

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    The plasma membrane route of rhodopsin to disk membranes
    Journal of Cell Science 2019 132: e1001
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    Separating nuclear and cytoplasmic proteomes after mitosis
    Journal of Cell Science 2019 132: e1002
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    Transcytosis relocates CFTR from basal to apical membranes
    Journal of Cell Science 2019 132: e1003
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    Restoring nuclear membrane defects with a fatty acid elongase
    Journal of Cell Science 2019 132: e1004
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    Death by necroptosis: FKBP12 found guilty
    Journal of Cell Science 2019 132: e1005

STICKY WICKET

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    The Gift
    Mole
    Journal of Cell Science 2019 132: jcs234112 doi: 10.1242/jcs.234112 Published 16 May 2019

FIRST PERSON

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    First person – Samantha Salvage
    Journal of Cell Science 2019 132: jcs233916 doi: 10.1242/jcs.233916 Published 21 May 2019
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    First person – Yasuha Kinugasa
    Journal of Cell Science 2019 132: jcs233585 doi: 10.1242/jcs.233585 Published 15 May 2019
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    First person – Abhishek Chadha
    Journal of Cell Science 2019 132: jcs233577 doi: 10.1242/jcs.233577 Published 15 May 2019

REVIEWS

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    Regulation of Cdc42 and its effectors in epithelial morphogenesis
    Franck Pichaud, Rhian F. Walther, Francisca Nunes de Almeida
    Journal of Cell Science 2019 132: jcs217869 doi: 10.1242/jcs.217869 Published 21 May 2019

    Summary: We review how spatial regulation of the small GTPase Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type.

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    CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease
    Jan van der Beek, Caspar Jonker, Reini van der Welle, Nalan Liv, Judith Klumperman
    Journal of Cell Science 2019 132: jcs189134 doi: 10.1242/jcs.189134 Published 15 May 2019

    Summary: The multitasking tethering complexes CORVET, CHEVI and HOPS are major organizers of the endocytic pathway. This Review combines current knowledge on their roles in membrane trafficking and diseases.

RESEARCH ARTICLES

  • Open Access
    Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse
    Samantha C. Salvage, Esther M. Gallant, Nicole A. Beard, Shiraz Ahmad, Haseeb Valli, James A. Fraser, Christopher L.-H. Huang, Angela F. Dulhunty
    Journal of Cell Science 2019 132: jcs229039 doi: 10.1242/jcs.229039 Published 21 May 2019

    Summary: The RyR2–P2328S mutation, precipitating potentially fatal arrhythmia in humans, can be attributed to leftward shifts in cytoplasmic Ca2+–dependent RyR2 activation and inactivation in the absence of adrenergic stimulation.

  • Open Access
    FKBP12 mediates necroptosis by initiating RIPK1–RIPK3–MLKL signal transduction in response to TNF receptor 1 ligation
    Zicheng Wang, Jiannan Feng, Jiyun Yu, Guozhu Chen
    Journal of Cell Science 2019 132: jcs227777 doi: 10.1242/jcs.227777 Published 20 May 2019

    Highlighted Article: FKBP12 is a novel target protein that acts in initiating necroptosis and the related systemic inflammatory response syndrome triggered by tumor necrosis factor.

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    Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/β-catenin signaling pathway
    Liying Liang, Yalin Tu, Jing Lu, Panxia Wang, Zhen Guo, Qianqian Wang, Kaiteng Guo, Rui Lan, Hong Li, Peiqing Liu
    Journal of Cell Science 2019 132: jcs228478 doi: 10.1242/jcs.228478 Published 16 May 2019

    Summary: The Dkk1–Wnt/β-catenin signaling axis has a crucial role in Dox-induced cardiotoxicity, suggesting a potential therapeutic approach for treatment of cardiomyopathy caused by clinical use of Dox.

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    Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium
    D. Bazzoun, H. A. Adissu, L. Wang, A. Urazaev, I. Tenvooren, S. F. Fostok, S. Chittiboyina, J. Sturgis, K. Hodges, G. Chandramouly, P.-A. Vidi, R. S. Talhouk, S. A. Lelièvre
    Journal of Cell Science 2019 132: jcs223313 doi: 10.1242/jcs.223313 Published 16 May 2019

    Summary: Gap junction protein connexin 43 (GJA1) contributes to breast epithelial polarity by modulating mitotic spindle orientation to prevent multilayering of the epithelium typically associated with tumor onset.

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    Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A
    Thibault Courthéoux, David Reboutier, Thibaut Vazeille, Jean-Yves Cremet, Christelle Benaud, Isabelle Vernos, Claude Prigent
    Journal of Cell Science 2019 132: jcs231118 doi: 10.1242/jcs.231118 Published 16 May 2019

    Summary: Midzone localization of γ-TuRC-anchoring protein NEDD1 in anaphase results from phosphorylation at serine 405 by Aurora A, regulating microtubule nucleation during central spindle assembly.

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    The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells
    Yasuha Kinugasa, Yasuhiro Hirano, Megumi Sawai, Yusuke Ohno, Tomoko Shindo, Haruhiko Asakawa, Yuji Chikashige, Shinsuke Shibata, Akio Kihara, Tokuko Haraguchi, Yasushi Hiraoka
    Journal of Cell Science 2019 132: jcs229021 doi: 10.1242/jcs.229021 Published 15 May 2019

    Highlighted Article: Absence of nuclear membrane proteins Lem2 and Bqt4 causes lethal defects associated with loss of the nuclear barrier function; the very-long-chain fatty acid elongase Elo2 rescues such lethal defects.

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    The route of the visual receptor rhodopsin along the cilium
    Abhishek Chadha, Stefanie Volland, Natella V. Baliaouri, Elaine M. Tran, David S. Williams
    Journal of Cell Science 2019 132: jcs229526 doi: 10.1242/jcs.229526 Published 15 May 2019

    Highlighted Article: The unresolved question of the route that rhodopsin travels along the cilium to accommodate disk membrane morphogenesis was addressed; it was found to be exclusively plasmalemmal.

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    Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting
    Aurélien Bidaud-Meynard, Florian Bossard, Andrea Schnúr, Ryosuke Fukuda, Guido Veit, Haijin Xu, Gergely L. Lukacs
    Journal of Cell Science 2019 132: jcs226886 doi: 10.1242/jcs.226886 Published 15 May 2019

    Highlighted Article: Apical transcytosis is indispensable for the maintenance of highly polarized CFTR expression by counteracting its basolateral missorting from the secretory and apical endocytic pathways in human bronchial epithelial cells.

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    Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro
    Dinisha Cyril Pirapaharan, Jacob Bastholm Olesen, Thomas Levin Andersen, Sandra Bjerre Christensen, Per Kjærsgaard-Andersen, Jean-Marie Delaisse, Kent Søe
    Journal of Cell Science 2019 132: jcs229351 doi: 10.1242/jcs.229351 Published 15 May 2019

    Summary: Osteoblast lineage cells directly stimulate osteoclastic bone resorption and promote the aggressive trench-resorption mode by exerting a matrix metalloproteinase-dependent catabolic activity.

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    STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and ICRAC
    Esther Lopez, Irene Frischauf, Isaac Jardin, Isabella Derler, Martin Muik, Carlos Cantonero, Gines M. Salido, Tarik Smani, Juan A. Rosado, Pedro C. Redondo
    Journal of Cell Science 2019 132: jcs226019 doi: 10.1242/jcs.226019 Published 15 May 2019

    Summary: STIM1 Y316 phosphorylation results in SARAF dissociation from STIM1, facilitating its activation and interaction with Orai1, then leading to SOCE activation.

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    Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis
    Menno Spits, Lennert J. Janssen, Lenard M. Voortman, Raymond Kooij, Anna C. M. Neefjes, Huib Ovaa, Jacques Neefjes
    Journal of Cell Science 2019 132: jcs225524 doi: 10.1242/jcs.225524 Published 15 May 2019

    Highlighted Article: Nuclear envelope formation around condensed chromatin excludes cytosolic proteins while nuclear proteins, including the proteasome, are then re-imported by conditional nuclear import mechanisms.

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    A unique role for clathrin light chain A in cell spreading and migration
    Oxana M. Tsygankova, James H. Keen
    Journal of Cell Science 2019 132: jcs224030 doi: 10.1242/jcs.224030 Published 15 May 2019

    Summary: The highly conserved clathrin light chain A, whose function has been elusive, promotes integrin-mediated signaling, association of clathrin with the WAVE complex, and efficient cell spreading and migration.

PUBLISHER'S NOTE

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    Expression of Concern: Gene trap analysis of germ cell signaling to Sertoli cells: NGF-TrkA mediated induction of Fra1 and Fos by post-meiotic germ cells
    F. Vidal, P. Lopez, L. A. Lopez-Fernandez, F. Ranc, J. C. Scimeca, F. Cuzin, M. Rassoulzadegan
    Journal of Cell Science 2019 132: jcs233692 doi: 10.1242/jcs.233692 Published 15 May 2019

CORRECTION

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    Correction: A synthetic biology platform for the reconstitution and mechanistic dissection of LINC complex assembly (doi:10.1242/jcs.219451)
    Sagardip Majumder, Patrick T. Willey, Maxwell S. DeNies, Allen P. Liu, G. W. Gant Luxton
    Journal of Cell Science 2019 132: jcs234153 doi: 10.1242/jcs.234153 Published 17 May 2019

PREPRINT HIGHLIGHTS

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    The latest from the preLights community – May 2019
    Journal of Cell Science 2019 132: p1001
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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    The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

    Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
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    Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

    Sarah O'Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong, Hayden Schneider, Wei Q. Shi, Stephen High
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