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June, 2019; 132 (11)

RESEARCH HIGHLIGHTS

  • You have accessSubscription required
    MAPK allows cancer cells to squeeze through tight spaces
    Journal of Cell Science 2019 132: e1101
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    GemC1 teams up with p73 for multiciliogenesis
    Journal of Cell Science 2019 132: e1102
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    MACET4 promotes microtubule nucleation in plants
    Journal of Cell Science 2019 132: e1103
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    β1-integrin recycling regulates cancer cell motility
    Journal of Cell Science 2019 132: e1104

STICKY WICKET

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    Dignity I
    Mole
    Journal of Cell Science 2019 132: jcs233601 doi: 10.1242/jcs.233601 Published 31 May 2019

FIRST PERSON

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    First person – Sharol Schmidt
    Journal of Cell Science 2019 132: jcs234328 doi: 10.1242/jcs.234328 Published 5 June 2019
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    First person – Mayank Sharma
    Journal of Cell Science 2019 132: jcs234245 doi: 10.1242/jcs.234245 Published 3 June 2019
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    First person – Hideaki Tanaka
    Journal of Cell Science 2019 132: jcs234310 doi: 10.1242/jcs.234310 Published 3 June 2019
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    First person – Maria-Eleni Lalioti
    Journal of Cell Science 2019 132: jcs233924 doi: 10.1242/jcs.233924 Published 3 June 2019
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    First person – Ioannis Xanthis
    Journal of Cell Science 2019 132: jcs233593 doi: 10.1242/jcs.233593 Published 31 May 2019
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    First person – Dominika Agnieszka Rudzka
    Journal of Cell Science 2019 132: jcs234161 doi: 10.1242/jcs.234161 Published 31 May 2019

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Vaishnavi Ananthanarayanan
    Journal of Cell Science 2019 132: jcs234088 doi: 10.1242/jcs.234088 Published 31 May 2019

CELL SCIENCE AT A GLANCE

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    Microtubule minus-end regulation at a glance
    Anna Akhmanova, Michel O. Steinmetz
    Journal of Cell Science 2019 132: jcs227850 doi: 10.1242/jcs.227850 Published 7 June 2019

    Summary: In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge on the dynamics, organization and regulation of microtubule minus ends.

REVIEW

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    Molecular mechanisms of chemotropism and cell fusion in unicellular fungi
    Sophie G. Martin
    Journal of Cell Science 2019 132: jcs230706 doi: 10.1242/jcs.230706 Published 31 May 2019

    Summary: A summary of the current knowledge on chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion.

SHORT REPORT

  • Open Access
    Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations
    Simon Brayford, Fiona N. Kenny, Toru Hiratsuka, Eduardo Serna-Morales, Lawrence Yolland, Andrei Luchici, Brian M. Stramer
    Journal of Cell Science 2019 132: jcs223974 doi: 10.1242/jcs.223974 Published 31 May 2019

    Summary: Active cell repulsion, driven by ephrin and ERK signalling, is required for fibrosarcoma cells to segregate from epithelial cells in culture.

RESEARCH ARTICLES

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    Shear stress-induced nuclear shrinkage through activation of Piezo1 channels in epithelial cells
    Deekshitha Jetta, Philip A. Gottlieb, Deepika Verma, Frederick Sachs, Susan Z. Hua
    Journal of Cell Science 2019 132: jcs226076 doi: 10.1242/jcs.226076 Published 12 June 2019

    Summary: Fluid shear stress causes nuclear shrinkage through a Ca2+-dependent signaling pathway, and the Piezo1 channel is a key element for transmitting the shear force input to nuclei.

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    GGA2 and RAB13 promote activity-dependent β1-integrin recycling
    Pranshu Sahgal, Jonna Alanko, Jaroslav Icha, Ilkka Paatero, Hellyeh Hamidi, Antti Arjonen, Mika Pietilä, Anne Rokka, Johanna Ivaska
    Journal of Cell Science 2019 132: jcs233387 doi: 10.1242/jcs.233387 Published 7 June 2019

    Highlighted Article: Characterization of a new endosomal complex, comprising GGA2 and RAB13, that promotes recycling of endocytosed active β1-integrin to the plasma membrane, to support the migration of breast cancer cells.

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    Identification and characterization of the land-plant-specific microtubule nucleation factor MACET4
    Sharol Schmidt, Andrei Smertenko
    Journal of Cell Science 2019 132: jcs232819 doi: 10.1242/jcs.232819 Published 5 June 2019

    Highlighted Article: The embryophyte-specific protein MACET4 is a cell cycle-regulated protein that localizes to the phragmoplast distal zones and nucleates microtubules in vitro.

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    DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes
    Bettina Noll, David Benz, Yannick Frey, Florian Meyer, Manuel Lauinger, Stephan A. Eisler, Simone Schmid, Peter L. Hordijk, Monilola A. Olayioye
    Journal of Cell Science 2019 132: jcs223172 doi: 10.1242/jcs.223172 Published 5 June 2019

    Summary: Loss of the RhoGAP protein DLC3, a putative tumor suppressor, enhances fast recycling of the metalloproteinase MT1-MMP and cellular matrix-degrading activity.

  • Open Access
    β1 integrin is a sensor of blood flow direction
    Ioannis Xanthis, Celine Souilhol, Jovana Serbanovic-Canic, Hannah Roddie, Antreas C. Kalli, Maria Fragiadaki, Raymond Wong, Dhruv R. Shah, Janet A. Askari, Lindsay Canham, Nasreen Akhtar, Shuang Feng, Victoria Ridger, Jonathan Waltho, Emmanuel Pinteaux, Martin J. Humphries, Matthew T. Bryan, Paul C. Evans
    Journal of Cell Science 2019 132: jcs229542 doi: 10.1242/jcs.229542 Published 3 June 2019

    Summary: By using flow systems, magnetic tweezers and knockout mice, we show that β1 integrin is activated by unidirectional hemodynamic shear force leading to Ca2+ signalling and cell alignment, but it is not activated by bidirectional force.

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    LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP
    Hiroshi Hanafusa, Takuya Yagi, Haruka Ikeda, Naoki Hisamoto, Tomoki Nishioka, Kozo Kaibuchi, Kyoko Shirakabe, Kunihiro Matsumoto
    Journal of Cell Science 2019 132: jcs228809 doi: 10.1242/jcs.228809 Published 3 June 2019

    Summary: LRRK1 phosphorylates Rab7 at S72. This increases the association of Rab7 with its effector RILP, resulting in enhanced minus-end transport of EGFR-containing endosomes through a dynein-dependent mechanism.

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    GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73
    Maria-Eleni Lalioti, Marina Arbi, Ioannis Loukas, Konstantina Kaplani, Argyro Kalogeropoulou, Georgia Lokka, Christina Kyrousi, Athanasia Mizi, Theodore Georgomanolis, Natasa Josipovic, Dimitrios Gkikas, Vladimir Benes, Panagiotis K. Politis, Argyris Papantonis, Zoi Lygerou, Stavros Taraviras
    Journal of Cell Science 2019 132: jcs228684 doi: 10.1242/jcs.228684 Published 3 June 2019

    Highlighted Article: GemC1 within the trimeric GemC1–E2F5–p73 complex regulates transcriptional activation of p73 and modifies the chromatin organization of the p73 locus in order to generate multiciliated cells.

  • Open Access
    DnaJB6 is a RanGTP-regulated protein required for microtubule organization during mitosis
    Miquel Rosas-Salvans, Jacopo Scrofani, Aitor Modol, Isabelle Vernos
    Journal of Cell Science 2019 132: jcs227033 doi: 10.1242/jcs.227033 Published 3 June 2019

    Summary: DnaJB6 is a novel RanGTP-regulated protein that appears to play an important role in dynein-dependent spindle organization and spindle assembly.

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    The cancer-associated meprin β variant G32R provides an additional activation site and promotes cancer cell invasion
    Henning Schäffler, Wenjia Li, Ole Helm, Sandra Krüger, Christine Böger, Florian Peters, Christoph Röcken, Susanne Sebens, Ralph Lucius, Christoph Becker-Pauly, Philipp Arnold
    Journal of Cell Science 2019 132: jcs220665 doi: 10.1242/jcs.220665 Published 31 May 2019

    Summary: A single amino acid change renders meprin β more active at the cell surface and reduces its ADAM17-mediated shedding.

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    Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent apoptosis pathway
    Hideaki Tanaka, Tomohiko Okazaki, Saeko Aoyama, Mutsumi Yokota, Masato Koike, Yasushi Okada, Yukio Fujiki, Yukiko Gotoh
    Journal of Cell Science 2019 132: jcs224766 doi: 10.1242/jcs.224766 Published 31 May 2019

    Summary: Peroxisomes regulate mitochondrial morphology through a Drp1-dependent mechanism and suppress the execution of stress-induced mitochondrion-dependent apoptosis.

  • Open Access
    Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization
    Dominika A. Rudzka, Giulia Spennati, David J. McGarry, Ya-Hua Chim, Matthew Neilson, Aleksandra Ptak, June Munro, Gabriela Kalna, Ann Hedley, Daniela Moralli, Catherine Green, Susan Mason, Karen Blyth, Margaret Mullin, Huabing Yin, Michael F. Olson
    Journal of Cell Science 2019 132: jcs224071 doi: 10.1242/jcs.224071 Published 31 May 2019

    Highlighted Article: Selection for tumour cells that efficiently pass through narrow diameter microporous membranes reveals a prominent role for MAPK signalling in regulating cell elasticity.

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    STIM1-dependent membrane insertion of heteromeric TRPC1–TRPC4 channels in response to muscarinic receptor stimulation
    Keita Harada, Hidetada Matsuoka, Masumi Inoue
    Journal of Cell Science 2019 132: jcs227389 doi: 10.1242/jcs.227389 Published 31 May 2019

    Summary: Muscarinic receptor stimulation in adrenal medullary cells induces excitation and catecholamine secretion, in part due to insertion of TRPC1–TRPC4 channels into the cell membrane.

TOOLS AND RESOURCES

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    Targeting specificity of nuclear-encoded organelle proteins with a self-assembling split-fluorescent protein toolkit
    Mayank Sharma, Carola Kretschmer, Christina Lampe, Johannes Stuttmann, Ralf Bernd Klösgen
    Journal of Cell Science 2019 132: jcs230839 doi: 10.1242/jcs.230839 Published 3 June 2019

    Summary: Optimization of the self-assembling split-GFP system and the assessment of protein-targeting specificity to endosymbiotic organelles in plant cells, utilizing a Golden Gate-based vector toolkit.

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    Proximity-dependent biotinylation mediated by TurboID to identify protein–protein interaction networks in yeast
    Marc Larochelle, Danny Bergeron, Bruno Arcand, François Bachand
    Journal of Cell Science 2019 132: jcs232249 doi: 10.1242/jcs.232249 Published 31 May 2019

    Summary: This work describes a simple and effective assay to screen for protein-protein interactions in yeast by using proximity-dependent biotinylation.

PUBLISHER'S NOTE

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    Expression of Concern: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (doi:10.1242/jcs.02784)
    Raffaella Guerriero, Isabella Parolini, Ugo Testa, Paola Samoggia, Eleonora Petrucci, Massimo Sargiacomo, Cristiana Chelucci, Marco Gabbianelli, Cesare Peschle
    Journal of Cell Science 2019 132: jcs233684 doi: 10.1242/jcs.233684 Published 31 May 2019

CORRECTION

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    Correction: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (doi:10.1242/jcs.02784)
    Raffaella Guerriero, Isabella Parolini, Ugo Testa, Paola Samoggia, Eleonora Petrucci, Massimo Sargiacomo, Cristiana Chelucci, Marco Gabbianelli, Cesare Peschle
    Journal of Cell Science 2019 132: jcs233676 doi: 10.1242/jcs.233676 Published 31 May 2019
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  • CELL SCIENCE AT A GLANCE
  • REVIEW
  • SHORT REPORT
  • RESEARCH ARTICLES
  • TOOLS AND RESOURCES
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  • CORRECTION

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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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    The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

    Anthony Ravussin, Andreas Brech, Sharon A. Tooze, Harald Stenmark
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    Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

    Sarah O'Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong, Hayden Schneider, Wei Q. Shi, Stephen High
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