RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
REVIEWS
- Lipid droplet–membrane contact sites – from protein binding to function
Summary: This Review summarizes the main principles of protein-lipid droplet (LD) interactions and recent evidence indicating the importance of contact sites with other organelles in the regulation of LD functions.
- Molecular form and function of the cytokinetic ring
Summary: This Review highlights new findings about the arrangement of molecules within the force-generating cytokinetic ring from studies using advanced microscopy techniques and in vitro approaches.
SHORT REPORT
- The asymmetric chemical structures of two mating pheromones reflect their differential roles in mating of fission yeast
Summary: Lipid pheromone peptides secreted locally from one cell may be concentrated at the fusion site with an opposite mating-type cell, which then polarizes to enable successful conjugation in S. pombe.
RESEARCH ARTICLES
- Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity
Highlighted Article: Distinct substrate specificities of Lag1 and Lac1, the two yeast ceramide synthases, are revealed, shedding light on their physiological roles.
- Dual role for fungal-specific outer kinetochore proteins during cell cycle and development in Magnaporthe oryzae
Summary: DASH complex proteins are differentially recruited to the nucleus during cell division and are intriguingly involved in polarised growth during development and differentiation in the rice blast fungus.
- HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates
Summary: The cartwheel structure, a universal template of the centriole, is necessary for the integrity of centriole intermediates up to the early S phase, but dispensable for subsequent centriole elongation and maturation.
- RACK1 evolved species-specific multifunctionality in translational control through sequence plasticity within a loop domain
Highlighted Article: Sequence divergence within a poorly understood loop domain of RACK1 functions to control two distinct aspects of translation in different species.
- Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis
Summary: Microridges on the apical surface of zebrafish peridermal cells are regulated by the conserved polarity kinase aPKC. We show that Nup358-mediated SUMO-modification of aPKC is crucial for this function.
- Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy
Highlighted Article: To finalize mitosis, half-maximal occupancy of kinetochores by microtubules is sufficient to overcome the inhibitory effect of the spindle assembly checkpoint.
- New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules
Highlighted Article: Novel functions for the de-ubiquitylating enzyme OTUD4 in RNA binding, stress granule formation and neuronal RNA transport granules are presented.
- WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine
Summary: WIP-1 and DBN-1, two actin-binding proteins, link the actin assembly to endocytic sites and cooperate with DYN-1 for clathrin-coated vesicle scission in the C. elegans intestine.
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Cell scientist to watch – Adrian Saurin
Adrian Saurin is a group leader at the University of Dundee, where he studies the spatial regulation of mitotic signalling networks with the support of a Cancer Research UK (CRUK) Programme Foundation Award. He talks about the winding path to a setting up his own group, his research program and much more.
Catch up with early-career first authors in our First Person interviews. Recently, we spoke to Shelby Bearrows, Javier Coy-Vergara, Anne Schaar, Nina Short and Max Butler.
Dina Coelho and Eduardo Moreno give an introduction to the molecular mechanisms of cell competition, and the biological relevance of competition in the nervous system in the context of Alzheimer’s disease.
Review - New insights into extracellular vesicle biogenesis and function
Marc Antonyak and colleagues highlight some of the recent findings regarding the roles of extracellular vesicles in physiological and pathological processes.
Mole - Wouldn't it be nice?
“Show some courtesy; do not simply decide that everything around you is yours. It's just rude. Wouldn't it be nice if people asked permission before they photographed your poster or presentation?”
Meet the Team
Journal of Cell Science Editors are going to be out and about in July.
Meet Senior Editor Petra Gross at the 2nd Mechanobiology meeting in Vietnam, Executive Editor Sharon Ahmad at the GRC Molecular membrane biology conference and Editor in Chief Michael Way and Reviews Editor Manuel Breuer at the GRC Motile and contractile systems conference.
New manuscript transfer network between JCS, JCB and MBoC
Journal of Cell Science (JCS), Journal of Cell Biology (JCB) and Molecular Biology of the Cell (MBoC) announce a new manuscript transfer option that will empower authors whose manuscripts have been declined to seamlessly transfer their manuscripts and associated peer review reports between the journals.
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Extended submission deadline: 15 August 2019.
preLights - Cytoskeletal tension actively sustains the migratory T cell synaptic contact
Tim Fessenden highlights a preprint from Darrel Irvine and team who reveal that actin foci establish a tensile network which sustains the immunological synapse formed during T cell activation.
Catch up with other recent preLights selected for the cell science community.
Data Science in Cell Imaging Workshop - Early-career researcher places available
Apply until 16 August 2019 for a funded early-career researcher place to attend our Workshop, which will be held at beautiful Wiston house.
Articles of interest in our sister journals
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
Ying Mao, Renjun Tu, Yan Huang, Decai Mao, Zhihao Yang, Pik Ki Lau, Jinhui Wang, Jianquan Ni, Yusong Guo, Ting Xie
Development 2019 146: dev174615
Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in vivo
Daniel B. Lybrand, Misha Naiman, Jessie May Laumann, Mitzi Boardman, Samuel Petshow, Kevin Hansen, Gregory Scott, Marcel Wehrli
Development 2019 146: dev164145