RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
REVIEWS
- Lipid droplet–membrane contact sites – from protein binding to function
Summary: This Review summarizes the main principles of protein-lipid droplet (LD) interactions and recent evidence indicating the importance of contact sites with other organelles in the regulation of LD functions.
- Molecular form and function of the cytokinetic ring
Summary: This Review highlights new findings about the arrangement of molecules within the force-generating cytokinetic ring from studies using advanced microscopy techniques and in vitro approaches.
SHORT REPORT
- The asymmetric chemical structures of two mating pheromones reflect their differential roles in mating of fission yeast
Summary: Lipid pheromone peptides secreted locally from one cell may be concentrated at the fusion site with an opposite mating-type cell, which then polarizes to enable successful conjugation in S. pombe.
RESEARCH ARTICLES
- Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity
Highlighted Article: Distinct substrate specificities of Lag1 and Lac1, the two yeast ceramide synthases, are revealed, shedding light on their physiological roles.
- Dual role for fungal-specific outer kinetochore proteins during cell cycle and development in Magnaporthe oryzae
Summary: DASH complex proteins are differentially recruited to the nucleus during cell division and are intriguingly involved in polarised growth during development and differentiation in the rice blast fungus.
- HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates
Summary: The cartwheel structure, a universal template of the centriole, is necessary for the integrity of centriole intermediates up to the early S phase, but dispensable for subsequent centriole elongation and maturation.
- RACK1 evolved species-specific multifunctionality in translational control through sequence plasticity within a loop domain
Highlighted Article: Sequence divergence within a poorly understood loop domain of RACK1 functions to control two distinct aspects of translation in different species.
- Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis
Summary: Microridges on the apical surface of zebrafish peridermal cells are regulated by the conserved polarity kinase aPKC. We show that Nup358-mediated SUMO-modification of aPKC is crucial for this function.
- Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy
Highlighted Article: To finalize mitosis, half-maximal occupancy of kinetochores by microtubules is sufficient to overcome the inhibitory effect of the spindle assembly checkpoint.
- New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules
Highlighted Article: Novel functions for the de-ubiquitylating enzyme OTUD4 in RNA binding, stress granule formation and neuronal RNA transport granules are presented.
- WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine
Summary: WIP-1 and DBN-1, two actin-binding proteins, link the actin assembly to endocytic sites and cooperate with DYN-1 for clathrin-coated vesicle scission in the C. elegans intestine.
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First Person interviews
Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Xuemeng Shi, Taisuke Seike, Hiral Shah and Indrasen Magre.
Abdou Rachid Thiam and Isabelle Dugail review the main principles of protein-lipid droplet (LD) interactions and recent evidence indicating the importance of contact sites with other organelles in the regulation of LD functions.
Review - Molecular form and function of the cytokinetic ring
MariaSanta Mangione and Kathleen Gould highlight new findings about the arrangement of molecules within the force-generating cytokinetic ring from studies using advanced microscopy techniques and in vitro approaches.
Mole - Dignity II
“It is one thing to doubt a result. It is a very different thing to doubt the intelligence, ability, and even the integrity of the one reporting it.”
Read Mole’s guide to scientific dignity.
Meet the Team
Journal of Cell Science Editors are going to be out and about in July.
Meet Senior Editor Petra Gross at the 2nd Mechanobiology meeting in Vietnam, Executive Editor Sharon Ahmad at the GRC Molecular membrane biology conference and Editor in Chief Michael Way and Reviews Editor Manuel Breuer at the GRC Motile and contractile systems conference.
New manuscript transfer network between JCS, JCB and MBoC
Journal of Cell Science (JCS), Journal of Cell Biology (JCB) and Molecular Biology of the Cell (MBoC) announce a new manuscript transfer option that will empower authors whose manuscripts have been declined to seamlessly transfer their manuscripts and associated peer review reports between the journals.
Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Extended submission deadline: 15 August 2019.
preLights - Cytoskeletal tension actively sustains the migratory T cell synaptic contact
Tim Fessenden highlights a preprint from Darrel Irvine and team who reveal that actin foci establish a tensile network which sustains the immunological synapse formed during T cell activation.
Catch up with other recent preLights selected for the cell science community.
Articles of interest in our sister journals
Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells
Julia Deathridge, Vlatka Antolović, Maddy Parsons, Jonathan R. Chubb
Development 2019 146: dev172940
The fate of cells undergoing spontaneous DNA damage during development
Agnes Miermont, Vlatka Antolović, Tchern Lenn, John M. E. Nichols, Lindsey J. Millward, Jonathan R. Chubb
Development 2019 146: dev174268