RESEARCH HIGHLIGHTS
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- Ubiquitin-based modifications in endothelial cell–cell contact and inflammation
Summary: Endothelial cell–cell contacts protect tissues from edema and uncontrolled invasion of inflammatory cells. Here, we discuss the emerging role of ubiquitylation of specific proteins controlling endothelial integrity and inflammation.
- How the mechanobiome drives cell behavior, viewed through the lens of control theory
Summary: Cells use sophisticated control systems to drive cell behaviors. The mechanobiome senses inputs, establishes and maintains system setpoint and integrates different cellular processes with mechanics to ensure robustness against disturbances.
RESEARCH ARTICLES
- The S. pombe adaptor protein Bbc1 regulates localization of Wsp1 and Vrp1 during endocytic actin patch assembly
Highlighted Article: The endocytic adaptor protein Bbc1 regulates endocytosis in fission yeast via its association with the myosin-I tail, thereby limiting association of the yeast WASp with myosin-1 at the base of endocytic invaginations.
- Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential
Highlighted Article: Circulating tumor cell clusters spread throughout the body by using a unique method to exit blood vessels, which grants the tumor cells an increased ability to form secondary tumors.
- Monoallelic, antisense and total RNA transcription in an in vitro neural differentiation system based on F1 hybrid mice
Summary: A quantification of the dynamics of monoallelic, antisense and poly(A)− expression, distinction between poly(A)+ and poly(A)− antisense transcripts, and bimorphic transcription during neural differentiation.
- DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy
Highlighted Article: DCAF8 is a novel MuRF1 interaction partner that promotes muscle atrophy and thereby links CRL4 ubiquitin ligase complexes to the loss of muscle mass.
- The golgin PpImh1 mediates reversible cisternal stacking in the Golgi of the budding yeast Pichia pastoris
Summary: In light of cisternal maturation, Golgi stacking needs to be reversible. The evolutionarily conserved GRIP domain golgin PpImh1 is implicated in such reversible cisternal stacking, suggesting a novel, but conserved mechanism.
- PPE39 of the Mycobacterium tuberculosis strain Beijing/K induces Th1-cell polarization through dendritic cell maturation
Summary: The Mtb Beijing/K-specific protein PPE39 induces maturation of dendritic cells via TLR4, promoting polarization of naïve CD4+ T cells towards the Th1-cell phenotype.
- Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration
Summary: The Joubert syndrome-causing protein, Ahi1, acts as a gatekeeper in regulating primary cilia protein composition and length. Ahi1 also regulates Arl13b stability, Shh signaling and cell migration.
- An acute decrease in plasma membrane tension induces macropinocytosis via PLD2 activation
Highlighted Article: A mechanical induction pathway of macropinocytosis is elicited by acute decrease of plasma membrane tension and followed by lipid/PLD2 nanodomain disintegration, PLD2 activation and PA production.
- The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane
Summary: ATP11C-b, a C-terminal splice variant of the PS-flippase ATP11C, localizes to a limited region of the plasma membrane in polarized cells, and LLXY residues are critical for the localization.
- Altering integrin engagement regulates membrane localization of Kir2.1 channels
Summary: Intracellular and extracellular signals affecting focal adhesions regulate the membrane localization of Kir2.1 channels to profoundly influence electrophysiology of excitable cells, including cardiomyocytes.
- Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway
Summary: In humans, sirtuin 7 plays a key role in the synthesis of ribosomal subunits by controlling critical endonucleolytic cleavages of precursor ribosomal RNAs.
This issue
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Other journals from The Company of Biologists
Intramembrane proteolysis at a glance: from signalling to protein degradation
In this Cell Science at a Glance article and accompanying poster, Nathalie Kühnle, Verena Dederer and Marius K. Lemberg review our current knowledge on the function of intramembrane proteolysis in mammalian cells.
Meeting report – Cell dynamics: organelle–cytoskeleton interface
Binyam Mogessie, Helen Zenner and Jörg Renkawitz summarise the Journal of Cell Science’s second meeting that was held in Lisbon, Portugal, earlier this year.
Mole – Impact!
"We love to speculate that if a paper is completely wrong, it will receive a great many citations saying how wrong it is (actually, I don't think this is true; if it's wrong, we tend to just fuggetaboutit)."
Read Mole’s thoughts on the issue of impact in scientific literature.
First Person interviews
Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Eric Clement Arakel, Alex Generous, Taylor Miller, Robert Bloodgood and Roger Sloboda, and Rachel Caines.
Journal of Cell Science announces Transparent peer review
In the interests of promoting transparency around the editorial process, Journal of Cell Science will now be publishing a ‘Peer review history’ file alongside published papers, where the author has opted in to such a file being published. All research papers submitted on or after 1 August 2019 are eligible. More information can be found here.
Journal of Cell Science (JCS), Journal of Cell Biology (JCB) and Molecular Biology of the Cell (MBoC) announce a new manuscript transfer option that will empower authors whose manuscripts have been declined to seamlessly transfer their manuscripts and associated peer review reports between the journals.
preLights - Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
Alyson Smith highlights a preprint that captures the fastest events in myosin’s ATPase cycle, which have remained opaque to previous assays.
Catch up with other recent preLights selected for the cell science community.
Articles of interest in our sister journals
Syndapin constricts microvillar necks to form a united rhabdomere in Drosophila photoreceptors
Sakiko Ogi, Atsushi Matsuda, Yuna Otsuka, Ziguang Liu, Takunori Satoh, Akiko K. Satoh (Development 2019 146: dev169292)
Tiantian Ji, Lina Zhang, Mingxi Deng, Shengshuo Huang, Ying Wang, Tri Thanh Pham, Andrew Alan Smith, Varun Sridhar, Clemens Cabernard, Jiguang Wang, Yan Yan (Disease Models & Mechanisms 2019 12: dmm040147)