RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEWS
- Microtubules at focal adhesions – a double-edged sword
Summary: A Review of the direct and indirect crosstalk between focal adhesions and microtubules.
- Tissue-specific roles of p73 in development and homeostasis
Summary: While p73, a member of the p53 family, has functions in cancer, p73 knockout mice also exhibit a diverse non-cancerous phenotype that has uncovered an astonishing breadth of cellular and molecular functions.
SHORT REPORT
- Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells
Summary: ROCK inhibition significantly promotes the outgrowth of cell projections in glioblastoma multiforme stem-like models, which in turn enabled the de novo formation of multicellular networks.
RESEARCH ARTICLES
- Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast
Summary: Independently of its interaction with the Sin1 subunit of TORC2, stress-activated MAPK positively regulates TORC2, constituting a signaling network for stress survival in fission yeast.
- Tetraspanin CD151 and integrin α3β1 contribute to the stabilization of integrin α6β4-containing cell-matrix adhesions
Highlighted Article: In keratinocytes, CD151 controls the stability of adhesion structures with a distinct molecular composition with hemidesmosome and tetraspanin features.
- Basal-type lumenogenesis in extraembryonic endoderm stem cells models the early visceral endoderm
Summary: This study reveals a stepwise process of basal-type lumenogenesis by extraembryonic endoderm stem cells in vitro and proposes a physiological interpretation.
- COMMD1 and PtdIns(4,5)P2 interaction maintain ATP7B copper transporter trafficking fidelity in HepG2 cells
Summary: Quantitative analysis of 3D protein colocalization defines the cellular function of COMMD1 in maintenance of ATP7B copper transporter trafficking fidelity and the importance of PtdIns(4,5)P2 in this action.
- Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes
Summary: Image-guided capture and sequencing of invasive cancer cells reveals novel leader- and follower-specific gene mutations, highlighting an important relationship between genomic and phenotypic heterogeneity during collective invasion.
- Local inhibition of rRNA transcription without nucleolar segregation after targeted ion irradiation of the nucleolus
Summary: Highly localized damage induced in nucleoli by carbon ion irradiation at the microbeam SNAKE only locally inhibits rRNA transcription, but does not cause nucleolar segregation.
- Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors
Summary: TGF-β signaling in skeletal muscle mesenchymal stromal cells suppresses PDGFRα expression and compromises PDGFRα-dependent signaling, resulting in impaired TGF-β-mediated responses.
- Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis
Summary: When the C. elegans embryo experiences mechanical stress during its first cell division, the direction of cortical flow needs to change so cytokinesis can be completed.
- SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor
Summary: A phosphoinositide-binding protein SH3YL1 binds to an ESCRT-I component Vps37B and plays an indispensable role in the degradative endosomal sorting of EGFR.
- Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair
Highlighted Article: Mutagenesis analysis of human centrin 2 reveals a separation of functions whereby centrin 2 that is defective in calcium binding can support nucleotide excision repair but not primary ciliogenesis.
- The RBG-1–RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans
Highlighted Article: Loss of function of the RBG-1-RBG-2 complex promotes lysosomal biogenesis and function, and also ameliorates the autophagy defect caused by mutations in the Vici syndrome gene EPG5.
- Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Summary: The Alkbh1 enzyme has an impact on mitochondrial respiration, but not on mitochondrial structure in human cells. Its knockdown induces mitochondrial UPR in human cells and C. elegans.