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April, 2019; 132 (7)

RESEARCH HIGHLIGHTS

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    A tyrosine phosphatase steers synapse co-transmission
    Journal of Cell Science 2019 132: e0701
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    Plant INM targeting likes the NLS
    Journal of Cell Science 2019 132: e0702
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    Separating talin's roles in adhesion
    Journal of Cell Science 2019 132: e0703
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    A central role for NIK in endothelial cell dysfunction signalling
    Journal of Cell Science 2019 132: e0704
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    A new experimental model for basement membranes
    Journal of Cell Science 2019 132: e0705

FIRST PERSON

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    First person – Bertille Bance and Shailaja Seetharaman
    Journal of Cell Science 2019 132: jcs231936 doi: 10.1242/jcs.231936 Published 9 April 2019
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    First person – Ioanna-Maria Gkotinakou
    Journal of Cell Science 2019 132: jcs231191 doi: 10.1242/jcs.231191 Published 8 April 2019
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    First person – Norman R. Groves
    Journal of Cell Science 2019 132: jcs231944 doi: 10.1242/jcs.231944 Published 3 April 2019
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    First person – Juan Tao
    Journal of Cell Science 2019 132: jcs231951 doi: 10.1242/jcs.231951 Published 3 April 2019

CELL SCIENTISTS TO WATCH

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    Interview with 2019 Hooke medal winner Eugenia Piddini
    Journal of Cell Science 2019 132: jcs231803 doi: 10.1242/jcs.231803 Published 1 April 2019
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    Cell scientist to watch – Pleasantine Mill
    Journal of Cell Science 2019 132: jcs231381 doi: 10.1242/jcs.231381 Published 1 April 2019

CELL SCIENCE AT A GLANCE

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    Survivin at a glance
    Sally P. Wheatley, Dario C. Altieri
    Journal of Cell Science 2019 132: jcs223826 doi: 10.1242/jcs.223826 Published 4 April 2019

    Summary: A mini-review highlighting our current understanding of the structure, function and cancer implications of survivin biology 21 years on from its initial discovery.

REVIEW

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    Bacterial mechanosensing: the force will be with you, always
    Vernita D. Gordon, Liyun Wang
    Journal of Cell Science 2019 132: jcs227694 doi: 10.1242/jcs.227694 Published 3 April 2019

    Summary: Very little is known about whether, and how, prokaryotes sense and respond to mechanical inputs. We review the emerging field of bacterial mechanosensing and indicate promising directions for future investigation.

SHORT REPORT

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    Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration
    Bertille Bance, Shailaja Seetharaman, Cécile Leduc, Batiste Boëda, Sandrine Etienne-Manneville
    Journal of Cell Science 2019 132: jcs225805 doi: 10.1242/jcs.225805 Published 5 April 2019

    Summary: Microtubule acetylation and detyrosination are independently regulated and have distinct functions during migration, with microtubule acetylation facilitating the turnover of focal adhesions.

RESEARCH ARTICLES

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    Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
    Catherine E. Gleason, Juan A. Oses-Prieto, Kathy H. Li, Bidisha Saha, Gavin Situ, Alma L. Burlingame, David Pearce
    Journal of Cell Science 2019 132: jcs224931 doi: 10.1242/jcs.224931 Published 9 April 2019

    Summary: The highly related but functionally distinct kinases, Akt and SGK1, are uniquely targeted by mTORC2; SGK1, but not Akt, requires mTORC2 phosphorylation at a perinuclear compartment for its activation.

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    ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling
    Ioanna-Maria Gkotinakou, Christina Befani, George Simos, Panagiotis Liakos
    Journal of Cell Science 2019 132: jcs225698 doi: 10.1242/jcs.225698 Published 8 April 2019

    Summary: Phosphorylation by ERK1/2 stimulates transcriptional activity of hypoxia-inducible factor-2α by inhibiting its CRM1- and NES-dependent nuclear export.

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    DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking
    Angela M. Howard, Kimberly S. LaFever, Aidan M. Fenix, Cherie' R. Scurrah, Ken S. Lau, Dylan T. Burnette, Gautam Bhave, Nicholas Ferrell, Andrea Page-McCaw
    Journal of Cell Science 2019 132: jcs226860 doi: 10.1242/jcs.226860 Published 8 April 2019

    Highlighted Article: When fed to Drosophila, the irritant DSS reproducibly damages basement membranes around the midgut. We show that this damage is repaired by a mechanism that requires matrix replacement and crosslinking.

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    NHX-type Na+(K+)/H+ antiporters are required for TGN/EE trafficking and endosomal ion homeostasis in Arabidopsis thaliana
    Jonathan Michael Dragwidge, Stefan Scholl, Karin Schumacher, Anthony Richard Gendall
    Journal of Cell Science 2019 132: jcs226472 doi: 10.1242/jcs.226472 Published 8 April 2019

    Summary: Plant NHX cation/proton exchangers are important for endosomal function and protein trafficking, highlighting the importance of controlling intracellular pH and ion homeostasis.

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    Distinct functions of a cGMP-dependent protein kinase in nerve terminal growth and synaptic vesicle cycling
    Jeffrey S. Dason, Aaron M. Allen, Oscar E. Vasquez, Marla B. Sokolowski
    Journal of Cell Science 2019 132: jcs227165 doi: 10.1242/jcs.227165 Published 5 April 2019

    Summary: This work highlights the multifaceted nature of kinases and provides mechanistic insight into how neurons balance synaptic vesicle exocytosis and endocytosis by identifying a cGMP-dependent protein kinase as a key regulator.

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    VAPB depletion alters neuritogenesis and phosphoinositide balance in motoneuron-like cells: relevance to VAPB-linked amyotrophic lateral sclerosis
    Paola Genevini, Maria Nicol Colombo, Rossella Venditti, Stefania Marcuzzo, Sara Francesca Colombo, Pia Bernasconi, Maria Antonietta De Matteis, Nica Borgese, Francesca Navone
    Journal of Cell Science 2019 132: jcs220061 doi: 10.1242/jcs.220061 Published 3 April 2019

    Summary: VAPB downregulation delays neurite elongation and increases Golgi- and acidic vesicle-associated phosphatidylinositol-4-phosphate in motoneuron-like cells, suggesting novel mechanisms for VAPB-linked amyotrophic lateral sclerosis.

  • Open Access
    Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling
    Gabriella M. Forte, Elizabeth Davie, Shervi Lie, Mirita Franz-Wachtel, Ashley J. Ovens, Tingting Wang, Jonathan S. Oakhill, Boris Maček, Iain M. Hagan, Janni Petersen
    Journal of Cell Science 2019 132: jcs223925 doi: 10.1242/jcs.223925 Published 3 April 2019

    Summary: ATP and AMP import from external environments modifies growth control in yeast and man.

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    Organization and function of tension-dependent complexes at adherens junctions
    Cordelia Rauskolb, Estelle Cervantes, Ferralita Madere, Kenneth D. Irvine
    Journal of Cell Science 2019 132: jcs224063 doi: 10.1242/jcs.224063 Published 3 April 2019

    Summary: This study characterizes the localization of Jub during development in Drosophila, and identifies a novel role for Jub in controlling myosin distribution and epithelial organization through regulation of cytohesin localization.

  • Open Access
    SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses
    Hanne Folz, Carlos A. Niño, Surayya Taranum, Stefanie Caesar, Lorenz Latta, François Waharte, Jean Salamero, Gabriel Schlenstedt, Catherine Dargemont
    Journal of Cell Science 2019 132: jcs224279 doi: 10.1242/jcs.224279 Published 3 April 2019

    Summary: Post-translational modifications, and in particular SUMOylation, of the nuclear basket subcomplex of the nuclear pore complex serve in its function as a sensor for mediating cellular stress signals.

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    Drosophila Ptp4E regulates vesicular packaging for monoamine-neuropeptide co-transmission
    Juan Tao, Dinara Bulgari, Drew A. Berkhoudt, Michael J. Calderon, Simon C. Watkins, Hector J. Fonseca Velez, Nadezhda Sabeva, David L. Deitcher, Edwin S. Levitan
    Journal of Cell Science 2019 132: jcs224568 doi: 10.1242/jcs.224568 Published 3 April 2019

    Highlighted Article: Although small-molecule and neuropeptide transmitters are packaged independently, a receptor protein tyrosine phosphatase regulates packaging of both transmitter classes, establishing a mechanism for scaling co-transmission.

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    TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis
    Shanshan Zhang, Wenjing Liu, Yeming Yang, Kuanxiang Sun, Shujin Li, Huijuan Xu, Mu Yang, Lin Zhang, Xianjun Zhu
    Journal of Cell Science 2019 132: jcs225052 doi: 10.1242/jcs.225052 Published 3 April 2019

    Summary: Deletion of TMEM30A in endothelial cells causes impaired cell proliferation, reduced tip cells and delayed vascular development toward the deep layers in the retina.

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    NIK–IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation
    Paulina Kucharzewska, Chrissta X. Maracle, Kim C. M. Jeucken, Jan Piet van Hamburg, Elisabeth Israelsson, Mark Furber, Sander W. Tas, Henric K. Olsson
    Journal of Cell Science 2019 132: jcs225615 doi: 10.1242/jcs.225615 Published 3 April 2019

    Highlighted Article: Accumulation of NIK, resulting from ligation of the lymphotoxin-β receptor, induces long-term IKK complex activation and potent enhancement of canonical NF-κB-mediated inflammation in human vascular endothelial cells.

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    A nuclear localization signal targets tail-anchored membrane proteins to the inner nuclear envelope in plants
    Norman R. Groves, Joseph F. McKenna, David E. Evans, Katja Graumann, Iris Meier
    Journal of Cell Science 2019 132: jcs226134 doi: 10.1242/jcs.226134 Published 3 April 2019

    Highlighted Article: A nuclear localization signal and a terminal transmembrane domain are sufficient to allow trafficking of proteins to the inner nuclear envelope in plants.

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    Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling
    Rolle Rahikainen, Tiina Öhman, Paula Turkki, Markku Varjosalo, Vesa P. Hytönen
    Journal of Cell Science 2019 132: jcs226514 doi: 10.1242/jcs.226514 Published 3 April 2019

    Highlighted Article: Transmission of mechanical forces through talin regulates adhesion complex composition and phosphotyrosine signaling. Talin rod subdomains and their mechanical activation are required for cell polarization and migration.

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  • Open Access

    SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72

    Mirjana Malnar, Boris Rogelj
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    Calcium elevations disrupt interactions between intraflagellar transport and the flagella membrane in Chlamydomonas

    Cecile Fort, Peter Collingridge, Colin Brownlee, Glen Wheeler
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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