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July, 2020; 133 (13)

RESEARCH HIGHLIGHTS

  • You have accessSubscription required
    Wash-ing large complexes by nuclear envelope budding
    Journal of Cell Science 2020 133: e1301
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    Uncovering the role of clathrin in Wnt/β-catenin signalling
    Journal of Cell Science 2020 133: e1302
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    Mitochondrial dynamics and ROS in the heat-shock response
    Journal of Cell Science 2020 133: e1303
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    A non-catalytic function for PI3Kγ in VSMC proliferation
    Journal of Cell Science 2020 133: e1304
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    PIP2 holds the key for engrailed-2 homeoprotein intercellular trafficking
    Journal of Cell Science 2020 133: e1305

JCS PRIZE

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    2019 Winner: Dominika Rudzka
    Michael Way (Editor-in-Chief)
    Journal of Cell Science 2020 133: jcs250282 doi: 10.1242/jcs.250282 Published 10 July 2020

STICKY WICKETS

  • You have accessSubscription required
    Toxic! I
    Mole
    Journal of Cell Science 2020 133: jcs249144 doi: 10.1242/jcs.249144 Published 1 July 2020
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    Toxic! II
    Mole
    Journal of Cell Science 2020 133: jcs249581 doi: 10.1242/jcs.249581 Published 7 July 2020

FIRST PERSON

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    First person – Tejeshwar Rao
    Journal of Cell Science 2020 133: jcs250381 doi: 10.1242/jcs.250381 Published 10 July 2020
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    First person – Megan Mc Fie
    Journal of Cell Science 2020 133: jcs250357 doi: 10.1242/jcs.250357 Published 9 July 2020
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    First person – Mang Zhu
    Journal of Cell Science 2020 133: jcs250365 doi: 10.1242/jcs.250365 Published 9 July 2020
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    First person – Nicholas Maskalenko
    Journal of Cell Science 2020 133: jcs250399 doi: 10.1242/jcs.250399 Published 9 July 2020

CELL SCIENCE AT A GLANCE

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    The myofibroblast at a glance
    Pardis Pakshir, Nina Noskovicova, Monika Lodyga, Dong Ok Son, Ronen Schuster, Amanda Goodwin, Henna Karvonen, Boris Hinz
    Journal of Cell Science 2020 133: jcs227900 doi: 10.1242/jcs.227900 Published 10 July 2020

    Summary: Myofibroblasts repair injured tissues by producing and contracting collagen scars but they also promote fibrosis. Here, we describe how to facilitate the design of informed anti-fibrotic therapies.

HYPOTHESIS

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    Exploring the interdependence between self-organization and functional morphology in cellular systems
    Gloria Mancinelli, Milos Galic
    Journal of Cell Science 2020 133: jcs242479 doi: 10.1242/jcs.242479 Published 3 July 2020

    Summary: In order to execute a specific function, cells often acquire a particular shape. Here, we explore the mechanisms driving these morphological changes.

REVIEW

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    The osteoclast cytoskeleton – current understanding and therapeutic perspectives for osteoporosis
    Anne Blangy, Guillaume Bompard, David Guerit, Pauline Marie, Justine Maurin, Anne Morel, Virginie Vives
    Journal of Cell Science 2020 133: jcs244798 doi: 10.1242/jcs.244798 Published 1 July 2020

    Summary: Osteoclasts are an amazing model to study interactions between cytoskeleton components; their role in osteoclast bone resorption activity can also open opportunities for the treatments against osteoporosis, as reviewed here.

SHORT REPORTS

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    A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage
    Adrien Lupieri, Régis Blaise, Alessandra Ghigo, Natalia Smirnova, Marie-Kerguelen Sarthou, Nicole Malet, Isabelle Limon, Pierre Vincent, Emilio Hirsch, Stéphanie Gayral, Damien Ramel, Muriel Laffargue
    Journal of Cell Science 2020 133: jcs245969 doi: 10.1242/jcs.245969 Published 9 July 2020

    Highlighted Article: PI3Kγ regulates VSMC proliferation independently of its kinase activity by controlling cAMP levels through PDE4D.

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    Cep57 and Cep57l1 function redundantly to recruit the Cep63–Cep152 complex for centriole biogenesis
    Huijie Zhao, Sen Yang, Qingxia Chen, Xiaomeng Duan, Guoqing Li, Qiongping Huang, Xueliang Zhu, Xiumin Yan
    Journal of Cell Science 2020 133: jcs241836 doi: 10.1242/jcs.241836 Published 3 July 2020

    Summary: Cep57 and its paralog Cep57l1 redundantly act as a molecular scaffold to recruit the Cep63–Cep152 complex to the proximal end of centrioles for centriole duplication.

RESEARCH ARTICLES

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    TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos
    Chenxi Guo, Sarah E. Webb, Ching Man Chan, Andrew L. Miller
    Journal of Cell Science 2020 133: jcs244780 doi: 10.1242/jcs.244780 Published 10 July 2020

    Summary: Characterization of two-pore channel type 2 (TPC2)-mediated Ca2+ release and ADP-ribosyl cyclase 1-like (ARC1-like) activity during axon extension of caudal primary motor neurons (CaPs) in zebrafish embryos.

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    EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation
    Tejeshwar C. Rao, Victor Pui-Yan Ma, Aaron Blanchard, Tara M. Urner, Shreya Grandhi, Khalid Salaita, Alexa L. Mattheyses
    Journal of Cell Science 2020 133: jcs238840 doi: 10.1242/jcs.238840 Published 10 July 2020

    Summary: EGFR regulates integrin tension and focal adhesion spatial organization and tunes the mechanical threshold for cell spreading and adhesion.

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    A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function
    Lena Dehnen, Maren Janz, Jitender Kumar Verma, Olympia Ekaterini Psathaki, Lars Langemeyer, Florian Fröhlich, Jürgen J. Heinisch, Heiko Meyer, Christian Ungermann, Achim Paululat
    Journal of Cell Science 2020 133: jcs247080 doi: 10.1242/jcs.247080 Published 9 July 2020

    Summary: Bulli forms a trimeric complex with Mon1–Ccz1 and is crucial for endosomal maturation in nephrocytes.

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    Perinuclear mitochondrial clustering, increased ROS levels, and HIF1 are required for the activation of HSF1 by heat stress
    Saloni Agarwal, Subramaniam Ganesh
    Journal of Cell Science 2020 133: jcs245589 doi: 10.1242/jcs.245589 Published 9 July 2020

    Highlighted Article: Mitochondrial positioning, ROS levels and the hypoxia response pathway are involved in the activation of the HSF1-mediated heat shock response pathway in mammals.

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    Trypanosomes have divergent kinesin-2 proteins that function differentially in flagellum biosynthesis and cell viability
    Robert L. Douglas, Brett M. Haltiwanger, Anna Albisetti, Haiming Wu, Robert L. Jeng, Joel Mancuso, W. Zacheus Cande, Matthew D. Welch
    Journal of Cell Science 2020 133: jcs129213 doi: 10.1242/jcs.129213 Published 9 July 2020

    Summary: Kinesin-2 proteins in Trypanosoma brucei perform a conserved role in flagellum biosynthesis and also have a specialized localization, emphasizing the evolutionary flexibility of kinesin function in trypanosomes.

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    Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae
    Mang Zhu, Erich R. Kuechler, Joyce Zhang, Or Matalon, Benjamin Dubreuil, Analise Hofmann, Chris Loewen, Emmanuel D. Levy, Joerg Gsponer, Thibault Mayor
    Journal of Cell Science 2020 133: jcs244657 doi: 10.1242/jcs.244657 Published 9 July 2020

    Summary: Mass spectrometry analysis reveals a large cohort of novel yeast stress granule proteins with intrinsic disordered regions that are sufficient for recruitment to the membraneless stress granule compartment.

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    Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
    Else Munthe, Camilla Raiborg, Harald Stenmark, Eva Maria Wenzel
    Journal of Cell Science 2020 133: jcs244467 doi: 10.1242/jcs.244467 Published 9 July 2020

    Highlighted Article: The exocytic function of clathrin controls the abundance of the Wnt signaling component β-catenin through LRP5/6 and cadherin molecules.

  • Open Access
    Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia
    Megan Mc Fie, Lada Koneva, Isabella Collins, Clarissa R. Coveney, Aisling M. Clube, Anastasios Chanalaris, Tonia L. Vincent, Jelena S. Bezbradica, Stephen N. Sansom, Angus K. T. Wann
    Journal of Cell Science 2020 133: jcs239871 doi: 10.1242/jcs.239871 Published 8 July 2020

    Summary: Ciliary proteins, acting independently of the ciliary axoneme, regulate the dynamics of cytosolic NFκB, but not other signalling pathways, defining an important subset of the inflammatory response.

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    Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP2
    Irène Amblard, Edmond Dupont, Isabel Alves, Julie Miralvès, Isabelle Queguiner, Alain Joliot
    Journal of Cell Science 2020 133: jcs244327 doi: 10.1242/jcs.244327 Published 8 July 2020

    Highlighted Article: We demonstrate that intercellular transfer of Engrailed homeoprotein involves direct translocation events across the plasma membrane and identify pivotal roles of PIP2 and cholesterol in these processes.

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    Cofilin is required for polarization of tension in stress fiber networks during migration
    Stacey Lee, Sanjay Kumar
    Journal of Cell Science 2020 133: jcs243873 doi: 10.1242/jcs.243873 Published 8 July 2020

    Summary: Mechanical polarization is established in stress fiber networks during migration through cofilin disassembling actin to facilitate the formation of highly prestressed stress fibers needed to break tensional symmetry.

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    Drosophila Wash and the Wash regulatory complex function in nuclear envelope budding
    Jeffrey M. Verboon, Mitsutoshi Nakamura, Kerri A. Davidson, Jacob R. Decker, Vivek Nandakumar, Susan M. Parkhurst
    Journal of Cell Science 2020 133: jcs243576 doi: 10.1242/jcs.243576 Published 8 July 2020

    Highlighted Article: Wash, the Wash regulatory complex, capping protein and Arp2/3 are identified as new components of nuclear envelope buds used for nuclear pore complex-independent export of large macromolecule complexes from the nucleus.

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    The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast
    Li Sun, Xiao-Min Liu, Wen-Zhu Li, Yuan-Yuan Yi, Xiangwei He, Yamei Wang, Quan-Wen Jin
    Journal of Cell Science 2020 133: jcs244863 doi: 10.1242/jcs.244863 Published 7 July 2020

    Summary: The molecular chaperone Hsp90 is involved in heterochromatic gene silencing and heterochromatin formation by facilitating stability and integrity of RNAi-dependent and -independent effectors in S. pombe.

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    Vacuolins and myosin VII are required for phagocytic uptake and phagosomal membrane recycling in Dictyostelium discoideum
    Cristina Bosmani, Florence Leuba, Nabil Hanna, Frauke Bach, Frédéric Burdet, Marco Pagni, Monica Hagedorn, Thierry Soldati
    Journal of Cell Science 2020 133: jcs242974 doi: 10.1242/jcs.242974 Published 6 July 2020

    Summary: Dictyostelium discoideum vacuolins are the functional homologs of flotillins and function in phagocytic uptake and membrane recycling together with myosin VII and talin A, as well as in phagolysosome biogenesis.

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    Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell–matrix adhesion
    Kenneth Wee, Soroor Hediyeh-zadeh, Kinga Duszyc, Suzie Verma, Bageshri N. Nanavati, Satyajeet Khare, Amrita Varma, Roger J. Daly, Alpha S. Yap, Melissa J. Davis, Srikanth Budnar
    Journal of Cell Science 2020 133: jcs235622 doi: 10.1242/jcs.235622 Published 6 July 2020

    Summary: Snail expression induces epithelial cell extrusion through transcriptional control of RhoA contractile signalling and cell–matrix adhesion that may act as a prelude to a metastatic event.

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    The DISC1–Girdin complex – a missing link in signaling to the T cell cytoskeleton
    Nicholas Maskalenko, Shubhankar Nath, Adarsh Ramakrishnan, Nadia Anikeeva, Yuri Sykulev, Martin Poenie
    Journal of Cell Science 2020 133: jcs242875 doi: 10.1242/jcs.242875 Published 6 July 2020

    Summary: DISC1, which is important for neuronal synapse formation, and Girdin, which is involved in cytoskeletal reorganization, play essential roles in actin accumulation and cytoskeletal reorganization at the T cell immunological synapse.

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    A cellular model of albumin endocytosis uncovers a link between membrane and nuclear proteins
    Seiya Urae, Yutaka Harita, Tomohiro Udagawa, Koji L. Ode, Masami Nagahama, Yuko Kajiho, Shoichiro Kanda, Akihiko Saito, Hiroki R. Ueda, Masaomi Nangaku, Akira Oka
    Journal of Cell Science 2020 133: jcs242859 doi: 10.1242/jcs.242859 Published 6 July 2020

    Summary: A cellular assay to evaluate albumin endocytosis reveals a novel link between a nuclear protein and a membrane receptor complex.

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    The Mre11-Rad50-Nbs1 complex mediates the robust recruitment of Polo to DNA lesions during mitosis in Drosophila
    Cedric Landmann, Priscillia Pierre-Elies, Damien Goutte-Gattat, Emilie Montembault, Marie-Charlotte Claverie, Anne Royou
    Journal of Cell Science 2020 133: jcs244442 doi: 10.1242/jcs.244442 Published 1 July 2020

    Summary: The kinetics of the DNA damage sensor Mre11 and the mitotic proteins Polo, BubR1, Bub3 at DNA lesions during mitosis are measured in Drosophila, revealing their order of recruitment.

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    Long-term segmentation-free assessment of head-flagellum movement and intracellular calcium in swimming human sperm

    G. Corkidi, P. Hernández-Herrera, F. Montoya, H. Gadêlha, A. Darszon
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    Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast

    Elizabeth Wood, Kazunori Kume, Francisco J. Navarro, Paul Nurse
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    Turgor-dependent and coronin-mediated F-actin dynamics drive septin disc-to-ring remodeling in the blast fungus

    Nawaraj Dulal, Audra Mae Rogers, Rinalda Proko, Baronger Dowell Bieger, Rohana Liyanage, Venkata Rao Krishnamurthi, Yong Wang, Martin John Egan
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    Ferroptosis induces membrane blebbing in placental trophoblasts

    Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, Claudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky
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    A region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the Drosophila egg

    Jennifer Michelle Potter-Birriel, Graydon B. Gonsalvez, William F. Marzluff
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