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July, 2020; 133 (14)

RESEARCH HIGHLIGHTS

  • You have accessSubscription required
    A new 3D tubuloid model to study polycystic kidney disease
    Journal of Cell Science 2020 133: e1401
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    A new robust histone modification analytical system
    Journal of Cell Science 2020 133: e1402
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    Ditching COPII on the way to the Golgi
    Journal of Cell Science 2020 133: e1403
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    Bringing RNAs to the mitotic spindle
    Journal of Cell Science 2020 133: e1404

EDITORIAL

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    FocalPlane – a meeting place for the microscopy minded
    Sharon Ahmad (Executive Editor), Christos Kyprianou (Community Manager, FocalPlane), Michael Way (Editor-in-Chief)
    Journal of Cell Science 2020 133: jcs250829 doi: 10.1242/jcs.250829 Published 15 July 2020

STICKY WICKETS

  • You have accessSubscription required
    Corona IX – sick of it
    Mole
    Journal of Cell Science 2020 133: jcs249896 doi: 10.1242/jcs.249896 Published 15 July 2020
  • You have accessSubscription required
    Corona X – yesterday and tomorrow and the day after that
    Mole
    Journal of Cell Science 2020 133: jcs249904 doi: 10.1242/jcs.249904 Published 15 July 2020

FIRST PERSON

  • You have accessSubscription required
    First person – Sachiko Fujiwara
    Journal of Cell Science 2020 133: jcs251082 doi: 10.1242/jcs.251082 Published 29 July 2020
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    First person – Laura Westrate
    Journal of Cell Science 2020 133: jcs251090 doi: 10.1242/jcs.251090 Published 27 July 2020
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    First person – Nuno Martins, Fernanda Cisneros-Soberanis and Elisa Pesenti
    Journal of Cell Science 2020 133: jcs251124 doi: 10.1242/jcs.251124 Published 24 July 2020
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    First person – Eryn Dixon
    Journal of Cell Science 2020 133: jcs250373 doi: 10.1242/jcs.250373 Published 21 July 2020
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    First person – Tigist Tamir
    Journal of Cell Science 2020 133: jcs251116 doi: 10.1242/jcs.251116 Published 16 July 2020

REVIEWS

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    The ubiquitin-like modifier FAT10 – much more than a proteasome-targeting signal
    Annette Aichem, Marcus Groettrup
    Journal of Cell Science 2020 133: jcs246041 doi: 10.1242/jcs.246041 Published 21 July 2020

    Summary: The determination of the structure of FAT10 has advanced our understanding of this unique ubiquitin-like modifier. Here, the latest insights about the function of non-covalent binding and conjugation to recently identified substrates are reviewed.

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    Mitochondrial dynamics during spermatogenesis
    Grigor Varuzhanyan, David C. Chan
    Journal of Cell Science 2020 133: jcs235937 doi: 10.1242/jcs.235937 Published 16 July 2020

    Summary: Spermatogenesis in mammals is associated with developmental changes in mitochondrial structure and metabolism. Mitochondrial dynamics has emerged as a key factor regulating mammalian spermatogenesis.

SHORT REPORT

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    Disease-associated keratin mutations reduce traction forces and compromise adhesion and collective migration
    Sachiko Fujiwara, Shinji Deguchi, Thomas M. Magin
    Journal of Cell Science 2020 133: jcs243956 doi: 10.1242/jcs.243956 Published 29 July 2020

    Summary: An epidermolysis bullosa simplex-associated keratin mutation causes defects in mechanotransduction. Keratin networks regulate traction force generation through a Rho signaling pathway upstream of cell–ECM adhesion formation and organized cell migration.

RESEARCH ARTICLES

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    PP2A­-B55γ counteracts Cdk1 and regulates proper spindle orientation through the cortical dynein adaptor NuMA
    Riya Keshri, Ashwathi Rajeevan, Sachin Kotak
    Journal of Cell Science 2020 133: jcs243857 doi: 10.1242/jcs.243857 Published 31 July 2020

    Summary: PP2A-B55γ orchestrates mitotic spindle behavior by dephosphorylating NuMA.

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    Conserved regions of budding yeast Tim22 have a role in structural organization of the carrier translocase
    Abhishek Kumar, Srujan Kumar Matta, Patrick D'Silva
    Journal of Cell Science 2020 133: jcs244632 doi: 10.1242/jcs.244632 Published 29 July 2020

    Summary: The functional significance of different regions of Tim22 remains elusive. We find that conserved regions of Tim22 play distinct roles in associations with partner subunits, thereby maintaining carrier translocase integrity.

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    PP2ACdc55 dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae
    Shoily Khondker, Sam Kajjo, Devon Chandler-Brown, Jan Skotheim, Adam Rudner, Amy E. Ikui
    Journal of Cell Science 2020 133: jcs243766 doi: 10.1242/jcs.243766 Published 29 July 2020

    Summary: PP2ACdc55-dependent Pds1 dephosphorylation leads to a dissociation of Esp1 from Pds1 causing an inhibition of spindle elongation, which plays a role in replication stress.

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    Osmotic gradients induce stable dome morphogenesis on extracellular matrix
    Sumire Ishida-Ishihara, Masakazu Akiyama, Kazuya Furusawa, Isao Naguro, Hiroki Ryuno, Takamichi Sushida, Seiichiro Ishihara, Hisashi Haga
    Journal of Cell Science 2020 133: jcs243865 doi: 10.1242/jcs.243865 Published 27 July 2020

    Summary: Basal hypertonic stress induces stable domes by both the swelling of extracellular matrix and aquaporin water transport.

  • Open Access
    Chromokinesin KIF4A teams up with stathmin 1 to regulate abscission in a SUMO-dependent manner
    Sabine A. G. Cuijpers, Edwin Willemstein, Jan G. Ruppert, Daphne M. van Elsland, William C. Earnshaw, Alfred C. O. Vertegaal
    Journal of Cell Science 2020 133: jcs248591 doi: 10.1242/jcs.248591 Published 24 July 2020

    Summary: A new mechanism of abscission regulation is identified through the dynamic interactions between KIF4A and stathmin 1 as controlled by SUMO modification of KIF4A.

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    RGS4 controls secretion of von Willebrand factor to the subendothelial matrix
    Francesca Patella, Daniel F. Cutler
    Journal of Cell Science 2020 133: jcs247312 doi: 10.1242/jcs.247312 Published 24 July 2020

    Summary: Changes in RGS4 expression alter levels of subendothelial, matrix-associated VWF, affecting platelet recruitment in a model of endothelial damage. This introduces a novel control over VWF function.

  • Open Access
    H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory
    Nuno M. C. Martins, Fernanda Cisneros-Soberanis, Elisa Pesenti, Natalia Y. Kochanova, Wei-Hao Shang, Tetsuya Hori, Takahiro Nagase, Hiroshi Kimura, Vladimir Larionov, Hiroshi Masumoto, Tatsuo Fukagawa, William C. Earnshaw
    Journal of Cell Science 2020 133: jcs242610 doi: 10.1242/jcs.242610 Published 24 July 2020

    Summary: Pericentric heterochromatin is dispensable for centromere epigenetic memory, but is required to stabilize centromere protein levels and accurate mitotic segregation. Pericentric heterochromatin levels can also recover after severe depletion.

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    Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis
    Richard G. Lee, Junjie Gao, Stefan J. Siira, Anne-Marie Shearwood, Judith A. Ermer, Vinzenz Hofferek, James C. Mathews, Minghao Zheng, Gavin E. Reid, Oliver Rackham, Aleksandra Filipovska
    Journal of Cell Science 2020 133: jcs240374 doi: 10.1242/jcs.240374 Published 24 July 2020

    Summary: Cardiolipin stabilises the interaction of the mitochondrial ribosome with the membrane to enable insertion of newly synthesised mitochondrial proteins into the inner membrane and form the respiratory chain supercomplexes.

  • Open Access
    Vesicular and uncoated Rab1-dependent cargo carriers facilitate ER to Golgi transport
    Laura M. Westrate, Melissa J. Hoyer, Michael J. Nash, Gia K. Voeltz
    Journal of Cell Science 2020 133: jcs239814 doi: 10.1242/jcs.239814 Published 24 July 2020

    Highlighted Article: Live-cell de novo cargo trafficking has revealed that secretory cargo is capable of leaving the endoplasmic reticulum in COPII-uncoated Rab1-dependent vesicle carriers.

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    Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle
    Sami Hassine, Florence Bonnet-Magnaval, Louis Philip Benoit Bouvrette, Bellastrid Doran, Mehdi Ghram, Mathieu Bouthillette, Eric Lecuyer, Luc DesGroseillers
    Journal of Cell Science 2020 133: jcs247155 doi: 10.1242/jcs.247155 Published 23 July 2020

    Highlighted Article: The RNA-binding protein Staufen1 mediates the localization of pre-ribosomal RNAs on mitotic spindle suggesting a novel role of Staufen1 in ribosome biogenesis and nucleoli reassembly.

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    Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7
    Madhavi Vijayan, Cheuk-Lun Lee, Vera H. H. Wong, Xia Wang, Kungfeng Bai, Jian Wu, Hannu Koistinen, Markku Seppälä, Kai-Fai Lee, William S. B. Yeung, Ernest H. Y. Ng, Philip C. N. Chiu
    Journal of Cell Science 2020 133: jcs244400 doi: 10.1242/jcs.244400 Published 23 July 2020

    Summary: Glycodelin-A is one of the key factors that induces the polarization of monocytes into decidual macrophages to regulate fetomaternal tolerance and placental development.

  • Open Access
    Endothelial protective factors BMP9 and BMP10 inhibit CCL2 release by human vascular endothelial cells
    Paul D. Upton, John E. S. Park, Patricia M. De Souza, Rachel J. Davies, Mark J. D. Griffiths, Stephen J. Wort, Nicholas W. Morrell
    Journal of Cell Science 2020 133: jcs239715 doi: 10.1242/jcs.239715 Published 21 July 2020

    Summary: Two proteins found in the blood, BMP9 and BMP10, reduce the production of CCL2, a protein that recruits inflammatory cells to the blood vessel wall.

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    FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly
    Richard Schregle, Stefanie Mueller, Daniel F. Legler, Jérémie Rossy, Wolfgang A. Krueger, Marcus Groettrup
    Journal of Cell Science 2020 133: jcs240085 doi: 10.1242/jcs.240085 Published 16 July 2020

    Summary: DALIS are cytoplasmic aggregates of ubiquitylated proteins and antigens in maturing dendritic cells. Ubiquitin-like modifier FAT10 is shown to localise to DALIS and to be involved in their disassembly.

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    Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor
    Tigist Y. Tamir, Brittany M. Bowman, Megan J. Agajanian, Dennis Goldfarb, Travis P. Schrank, Trent Stohrer, Andrew E. Hale, Priscila F. Siesser, Seth J. Weir, Ryan M. Murphy, Kyle M. LaPak, Bernard E. Weissman, Nathaniel J. Moorman, M. Ben Major
    Journal of Cell Science 2020 133: jcs241356 doi: 10.1242/jcs.241356 Published 15 July 2020

    Summary: BRSK2 suppresses NRF2 signaling by inhibiting protein synthesis through mTOR downregulation.

  • Open Access
    A heterodimeric SNX4­–SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly
    Zuriñe Antón, Virginie M. S. Betin, Boris Simonetti, Colin J. Traer, Naomi Attar, Peter J. Cullen, Jon D. Lane
    Journal of Cell Science 2020 133: jcs246306 doi: 10.1242/jcs.246306 Published 15 July 2020

    Summary: A heterodimeric SNX4–SNX7 SNX-BAR complex regulates mammalian autophagosome assembly through the control of ATG9 trafficking.

TOOLS AND RESOURCES

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    A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization
    Divya Ganapathi Sankaran, Alexander J. Stemm-Wolf, Bailey L. McCurdy, Bharath Hariharan, Chad G. Pearson
    Journal of Cell Science 2020 133: jcs243543 doi: 10.1242/jcs.243543 Published 30 July 2020

    Summary: A quantitative image-processing and machine learning-aided approach for the semi-automated analysis of centrosome amplification and MT organization defects in breast cancer cells.

  • Open Access
    Histone modification dynamics as revealed by multicolor immunofluorescence-based single-cell analysis
    Yoko Hayashi-Takanaka, Yuto Kina, Fumiaki Nakamura, Leontine E. Becking, Yoichi Nakao, Takahiro Nagase, Naohito Nozaki, Hiroshi Kimura
    Journal of Cell Science 2020 133: jcs243444 doi: 10.1242/jcs.243444 Published 21 July 2020

    Highlighted Article: Profiling histone modification dynamics during the cell cycle, in response to lysine demethylase overexpression and upon chemical inhibitor treatments.

  • Open Access
    GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD
    Eryn E. Dixon, Demetrios S. Maxim, Victoria L. Halperin Kuhns, Allison C. Lane-Harris, Patricia Outeda, Andrew J. Ewald, Terry J. Watnick, Paul A. Welling, Owen M. Woodward
    Journal of Cell Science 2020 133: jcs249557 doi: 10.1242/jcs.249557 Published 16 July 2020

    Highlighted Article: A new three-dimensional in vitro model drives tubule morphogenesis with the addition of GDNF and demonstrates methods for interrogating the initiation of ADPKD cystogenesis.

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  • Open Access

    Long-term segmentation-free assessment of head-flagellum movement and intracellular calcium in swimming human sperm

    G. Corkidi, P. Hernández-Herrera, F. Montoya, H. Gadêlha, A. Darszon
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    Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast

    Elizabeth Wood, Kazunori Kume, Francisco J. Navarro, Paul Nurse
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    Turgor-dependent and coronin-mediated F-actin dynamics drive septin disc-to-ring remodeling in the blast fungus

    Nawaraj Dulal, Audra Mae Rogers, Rinalda Proko, Baronger Dowell Bieger, Rohana Liyanage, Venkata Rao Krishnamurthi, Yong Wang, Martin John Egan
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    Ferroptosis induces membrane blebbing in placental trophoblasts

    Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, Claudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky
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    A region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the Drosophila egg

    Jennifer Michelle Potter-Birriel, Graydon B. Gonsalvez, William F. Marzluff
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