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August, 2020; 133 (15)

RESEARCH HIGHLIGHTS

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    Spectrin dynamics during neuronal development
    Journal of Cell Science 2020 133: e1501
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    A tug of war regulates epithelial cell shape
    Journal of Cell Science 2020 133: e1502
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    Knocksideways to better understand endosomal cargo sorting
    Journal of Cell Science 2020 133: e1503
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    MT1-MMP paves the way for agrin-induced presynaptic differentiation
    Journal of Cell Science 2020 133: e1504
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    Everything you need to study CME in plants
    Journal of Cell Science 2020 133: e1505

EDITORIAL

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    Thank you to our peer reviewers in 2019
    Michael Way (Editor-in-Chief), Sharon Ahmad (Executive Editor)
    Journal of Cell Science 2020 133: jcs250936 doi: 10.1242/jcs.250936 Published 3 August 2020

STICKY WICKETS

  • You have accessSubscription required
    Corona XI – zooming out
    Mole
    Journal of Cell Science 2020 133: jcs250076 doi: 10.1242/jcs.250076 Published 3 August 2020
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    Corona XII – punctuated equilibrium
    Mole
    Journal of Cell Science 2020 133: jcs250753 doi: 10.1242/jcs.250753 Published 3 August 2020

FIRST PERSON

  • You have accessSubscription required
    First person – Maiko Yamamoto
    Journal of Cell Science 2020 133: jcs251900 doi: 10.1242/jcs.251900 Published 12 August 2020
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    First person – Helena Sofia Domingues
    Journal of Cell Science 2020 133: jcs251934 doi: 10.1242/jcs.251934 Published 12 August 2020
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    First person – Rebecca San Gil
    Journal of Cell Science 2020 133: jcs251918 doi: 10.1242/jcs.251918 Published 12 August 2020
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    First person – Alexander Johnson
    Journal of Cell Science 2020 133: jcs251108 doi: 10.1242/jcs.251108 Published 12 August 2020

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Thomas Iskratsch
    Journal of Cell Science 2020 133: jcs251595 doi: 10.1242/jcs.251595 Published 3 August 2020

PERSPECTIVE

  • Open Access
    Science during lockdown – from virtual seminars to sustainable online communities
    Francesca Bottanelli, Bruno Cadot, Felix Campelo, Scott Curran, Patricia M. Davidson, Gautam Dey, Ishier Raote, Anne Straube, Matthew P. Swaffer
    Journal of Cell Science 2020 133: jcs249607 doi: 10.1242/jcs.249607 Published 14 August 2020

    Summary: A practical guide to organising sustainable and inclusive virtual seminar series.

REVIEWS

  • Open Access
    Chromosome–nuclear envelope tethering – a process that orchestrates homologue pairing during plant meiosis?
    Adél Sepsi, Trude Schwarzacher
    Journal of Cell Science 2020 133: jcs243667 doi: 10.1242/jcs.243667 Published 12 August 2020

    Summary: We review plant meiosis, including chromosome tethering at the nuclear periphery that, we propose, defines chromosome dynamics-facilitating DNA sequence-based pairing of homologues

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    Extracellular heparan sulfate proteoglycans and glycan-binding lectins orchestrate trans-synaptic signaling
    Emma Rushton, Danielle L. Kopke, Kendal Broadie
    Journal of Cell Science 2020 133: jcs244186 doi: 10.1242/jcs.244186 Published 11 August 2020

    Summary: A Review of the multitude of extracellular proteoglycans, glycan-binding lectins and secreted enzymes regulating trans-synaptic signaling at the Drosophila neuromuscular junction.

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    The UPRosome – decoding novel biological outputs of IRE1α function
    Hery Urra, Philippe Pihán, Claudio Hetz
    Journal of Cell Science 2020 133: jcs218107 doi: 10.1242/jcs.218107 Published 11 August 2020

    Summary: A review of how IRE1α, the most conserved UPR sensor, controls cell fate and several cellular processes through the engagement of a signaling platform named the UPRosome.

RESEARCH ARTICLES

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    Exploring the mechanistic and temporal regulation of LRP6 endocytosis in canonical WNT signaling
    Fiete Haack, Kai Budde, Adelinde M. Uhrmacher
    Journal of Cell Science 2020 133: jcs243675 doi: 10.1242/jcs.243675 Published 14 August 2020

    Summary: Computational modeling shows that LRP6 endocytosis in vertebrates is clathrin-independent and not restricted to lipid rafts or microdomains and further suggests that signalosome formation within microdomains delays LRP6 internalization.

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    The PRDM14–CtBP1/2–PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency
    Maiko Yamamoto, Yoshiaki Suwa, Kohta Sugiyama, Naoki Okashita, Masanori Kawaguchi, Naoki Tani, Kazumi Matsubara, Akira Nakamura, Yoshiyuki Seki
    Journal of Cell Science 2020 133: jcs240176 doi: 10.1242/jcs.240176 Published 14 August 2020

    Summary: CRISPR/Cas9-mediated knockout reveals the molecular hierarchy of the PRDM14, CBFA2T2, CtBP1/2 and PRC2 complex, which are required for the transcriptional repression in embryonic stem cells.

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    Interplay between actomyosin and E-cadherin dynamics regulates cell shape in the Drosophila embryonic epidermis
    Joshua Greig, Natalia A. Bulgakova
    Journal of Cell Science 2020 133: jcs242321 doi: 10.1242/jcs.242321 Published 12 August 2020

    Highlighted Article: Crosstalk between cell adhesion dynamics and actomyosin regulates epithelial cell shape. The p120-catenin protein facilitates this crosstalk through modulation of Arf1 and RhoA signalling.

  • Open Access
    CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly
    Koichiro Otake, Jun-ichirou Ohzeki, Nobuaki Shono, Kazuto Kugou, Koei Okazaki, Takahiro Nagase, Hisashi Yamakawa, Natalay Kouprina, Vladimir Larionov, Hiroshi Kimura, William C. Earnshaw, Hiroshi Masumoto
    Journal of Cell Science 2020 133: jcs243303 doi: 10.1242/jcs.243303 Published 11 August 2020

    Summary: The acidic domain of CENP-B facilitates assembly of various proteins at centromeric satellite DNA, including HP1 and ASH1L. CENP-B controls centromere epigenetic status.

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    miR-206 enforces a slow muscle phenotype
    Kristen K. Bjorkman, Martin G. Guess, Brooke C. Harrison, Michael M. Polmear, Angela K. Peter, Leslie A. Leinwand
    Journal of Cell Science 2020 133: jcs243162 doi: 10.1242/jcs.243162 Published 11 August 2020

    Summary: miR-206 regulates the slow contractile properties of skeletal and cardiac muscle. miR-206 deletion shifts slow muscles to a faster profile and results in cardiac dysfunction specifically in male mice.

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    Pseudohyphal growth in Saccharomyces cerevisiae involves protein kinase-regulated lipid flippases
    Merethe Mørch Frøsig, Sara Rute Costa, Johannes Liesche, Jeppe Thulin Østerberg, Susanne Hanisch, Sebastian Nintemann, Helle Sørensen, Michael Palmgren, Thomas Günther Pomorski, Rosa L. López-Marqués
    Journal of Cell Science 2020 133: jcs235994 doi: 10.1242/jcs.235994 Published 6 August 2020

    Summary: A poorly characterized phospholipid flippase in S. cerevisiae is involved in establishing phosphatidylserine asymmetry at the plasma membrane and has a role in the control of pseudohyphal growth.

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    The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans
    Ru Jia, Yongping Chai, Chao Xie, Gai Liu, Zhiwen Zhu, Kaiyao Huang, Wei Li, Guangshuo Ou
    Journal of Cell Science 2020 133: jcs248583 doi: 10.1242/jcs.248583 Published 5 August 2020

    Highlighted Article: Asymmetry and remodeling of the membrane skeleton might enable spatiotemporal modulation of membrane mechanics during distinct developmental events. C. elegans spectrin binds to ankyrin, and these proteins function to regulate neural development.

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    Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells
    Rebecca San Gil, Dezerae Cox, Luke McAlary, Tracey Berg, Adam K. Walker, Justin J. Yerbury, Lezanne Ooi, Heath Ecroyd
    Journal of Cell Science 2020 133: jcs243709 doi: 10.1242/jcs.243709 Published 5 August 2020

    Summary: Aggregation-prone proteins associated with neurodegenerative diseases impair or evade the heat shock response in neuronal cells.

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    Pushing myelination – developmental regulation of myosin expression drives oligodendrocyte morphological differentiation
    Helena Sofia Domingues, Mateusz M. Urbanski, Sandra Macedo-Ribeiro, Amr Almaktari, Azka Irfan, Yamely Hernandez, Haibo Wang, João Bettencourt Relvas, Boris Rubinstein, Carmen V. Melendez-Vasquez, Inês Mendes Pinto
    Journal of Cell Science 2020 133: jcs232264 doi: 10.1242/jcs.232264 Published 5 August 2020

    Summary: Non-muscle myosin II isoforms and myosin 18a have differing roles in coordinating cell-cortex tension release and myelin membrane expansion during oligodendrocyte development.

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    Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development
    Marilyn Janice Oentaryo, Anna Chung-Kwan Tse, Chi Wai Lee
    Journal of Cell Science 2020 133: jcs246710 doi: 10.1242/jcs.246710 Published 5 August 2020

    Highlighted Article: At developing Xenopus neuromuscular junctions, the proteolytic activity of neuronal MT1-MMP digests the surrounding ECM proteins and mediates Lrp4 cleavage to regulate agrin deposition and signaling during presynaptic differentiation, respectively.

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    Microtubule motor transport in the delivery of melanosomes to the actin-rich apical domain of the retinal pigment epithelium
    Mei Jiang, Antonio E. Paniagua, Stefanie Volland, Hongxing Wang, Adarsh Balaji, David G. Li, Vanda S. Lopes, Barry L. Burgess, David S. Williams
    Journal of Cell Science 2020 133: jcs242214 doi: 10.1242/jcs.242214 Published 4 August 2020

    Summary: The motility and localization of melanosomes in the retinal pigment epithelium are dependent on cytoplasmic dynein and myosin-7a, thus supporting a capture mechanism that involves both microtubules and actin motors.

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    Effects of a local auxiliary protein on the two-dimensional affinity of a TCR–peptide MHC interaction
    Victoria Junghans, Manto Chouliara, Ana Mafalda Santos, Deborah Hatherley, Jan Petersen, Tommy Dam, Lena M. Svensson, Jamie Rossjohn, Simon J. Davis, Peter Jönsson
    Journal of Cell Science 2020 133: jcs245985 doi: 10.1242/jcs.245985 Published 3 August 2020

    Summary: Two-dimensional affinity measurements of a T-cell receptor binding its agonistic peptide major histocompatibility complex molecule and the influence of cellular context.

  • Open Access
    Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting
    Ashley J. Evans, James L. Daly, Anis N. K. Anuar, Boris Simonetti, Peter J. Cullen
    Journal of Cell Science 2020 133: jcs246033 doi: 10.1242/jcs.246033 Published 3 August 2020

    Highlighted Article: Retromer, a master controller of endosomal cargo sorting, is deregulated in neurodegenerative disease. Here, we develop and apply a retromer knocksideways methodology to quantify endosomal cargo sorting upon acute perturbation.

TOOLS AND RESOURCES

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    Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis
    Alexander Johnson, Nataliia Gnyliukh, Walter A. Kaufmann, Madhumitha Narasimhan, Grégory Vert, Sebastian Y. Bednarek, Jiří Friml
    Journal of Cell Science 2020 133: jcs248062 doi: 10.1242/jcs.248062 Published 6 August 2020

    Highlighted Article: We present detailed novel quantitative imaging protocols, and review pharmacological and genetic manipulation for the investigation of clathrin-mediated endocytosis at multiple scales in Arabidopsis plants.

CORRECTION

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    Correction: Sensitive detection of protein ubiquitylation using a protein fragment complementation assay
    Marie Le Boulch, Audrey Brossard, Gaëlle Le Dez, Sébastien Léon, Gwenaël Rabut
    Journal of Cell Science 2020 133: jcs251389 doi: 10.1242/jcs.251389 Published 12 August 2020
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  • Open Access

    Long-term segmentation-free assessment of head-flagellum movement and intracellular calcium in swimming human sperm

    G. Corkidi, P. Hernández-Herrera, F. Montoya, H. Gadêlha, A. Darszon
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    Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast

    Elizabeth Wood, Kazunori Kume, Francisco J. Navarro, Paul Nurse
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    Turgor-dependent and coronin-mediated F-actin dynamics drive septin disc-to-ring remodeling in the blast fungus

    Nawaraj Dulal, Audra Mae Rogers, Rinalda Proko, Baronger Dowell Bieger, Rohana Liyanage, Venkata Rao Krishnamurthi, Yong Wang, Martin John Egan
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    Ferroptosis induces membrane blebbing in placental trophoblasts

    Kazuhiro Kajiwara, Ofer Beharier, Choon-Peng Chng, Julie P. Goff, Yingshi Ouyang, Claudette M. St Croix, Changjin Huang, Valerian E. Kagan, K. Jimmy Hsia, Yoel Sadovsky
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    A region of SLBP outside the mRNA processing domain is essential for deposition of histone mRNA into the Drosophila egg

    Jennifer Michelle Potter-Birriel, Graydon B. Gonsalvez, William F. Marzluff
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