RESEARCH HIGHLIGHTS
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CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- p63-related signaling at a glance
Summary: A review of the signaling cascades regulating and regulated by the different isoforms of the p53-related transcription factor p63, as well the role of p63 in disease.
REVIEWS
- Microautophagy – distinct molecular mechanisms handle cargoes of many sizes
Summary: Microautophagy is a versatile and conserved type of autophagy. Here, recent progress is reviewed that allows fission-type and fusion-type microautophagy to be distinguished, thus providing a new conceptual framework.
- Bring it back, bring it back, don't take it away from me – the sorting receptor RER1
Summary: In this Review we provide an overview of the early secretory pathway protein RER1, which cycles between cis-Golgi and ER, returning ER-resident proteins and unassembled subunits of multimeric complexes back to the ER.
RESEARCH ARTICLES
- Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas
Highlighted Article: Using GFP-tagged β-tubulin, we show that most of the tubulin required for axonemal assembly enters Chlamydomonas cilia by diffusion rather than by intraflagellar transport.
- Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure
Highlighted Article: A regulatory circuit maintaining intracellular amino acid homeostasis is revealed by studies of yeast growing under high hydrostatic pressure, with a critical role identified for the EGOC–Pib2–TORC1 complex.
- The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.
- LFA-1 signals to promote actin polymerization and upstream migration in T cells
Highlighted Article: Inflammatory responses require leukocyte migration along the vascular wall. We show that signaling from β2, but not β1, integrins induces cytoskeletal changes needed for upstream migration under shear flow.
- Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein
Highlighted Article: Fe65 is a major intracellular APP-binding protein. We show that Fe65 is a transcription factor, whose nuclear translocation and thus transcriptional capacity is regulated by APP cleavage.
- Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton
Summary: The ER–mitochondria tether maintained by MFN2 fine-tunes Rac activation to regulate neutrophil adhesive migration and adhesion to endothelial cells under shear stress.
- Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2
Summary: The interaction of the signal integrators AGS3 and DVL2 is regulated by protein phosphorylation, subcellular distribution, and a cell-surface G-protein-coupled receptor.
- The role of the α-tubulin acetyltransferase αTAT1 in the DNA damage response
Summary: The α-tubulin acetyltransferase αTAT1 is involved in DNA damage checkpoints and DNA repair through its acetyltransferase activity.
- Frustration of endocytosis potentiates compression-induced receptor signaling
Highlighted Article: Cancer cells subjected to compressive stress experience frustration of clathrin-mediated endocytosis which, in turn, leads to enhanced receptor signaling.
- RACK1 regulates centriole duplication through promoting the activation of polo-like kinase 1 by Aurora A
Summary: The BRCA1-interacting protein RACK1 regulates centriole duplication by acting as a scaffold protein for the phosphorylation of polo-like kinase 1 by Aurora A.