RESEARCH HIGHLIGHTS
STICKY WICKETS
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- p63-related signaling at a glance
Summary: A review of the signaling cascades regulating and regulated by the different isoforms of the p53-related transcription factor p63, as well the role of p63 in disease.
REVIEWS
- Microautophagy – distinct molecular mechanisms handle cargoes of many sizes
Summary: Microautophagy is a versatile and conserved type of autophagy. Here, recent progress is reviewed that allows fission-type and fusion-type microautophagy to be distinguished, thus providing a new conceptual framework.
- Bring it back, bring it back, don't take it away from me – the sorting receptor RER1
Summary: In this Review we provide an overview of the early secretory pathway protein RER1, which cycles between cis-Golgi and ER, returning ER-resident proteins and unassembled subunits of multimeric complexes back to the ER.
RESEARCH ARTICLES
- Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas
Highlighted Article: Using GFP-tagged β-tubulin, we show that most of the tubulin required for axonemal assembly enters Chlamydomonas cilia by diffusion rather than by intraflagellar transport.
- Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure
Highlighted Article: A regulatory circuit maintaining intracellular amino acid homeostasis is revealed by studies of yeast growing under high hydrostatic pressure, with a critical role identified for the EGOC–Pib2–TORC1 complex.
- The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.
- LFA-1 signals to promote actin polymerization and upstream migration in T cells
Highlighted Article: Inflammatory responses require leukocyte migration along the vascular wall. We show that signaling from β2, but not β1, integrins induces cytoskeletal changes needed for upstream migration under shear flow.
- Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein
Highlighted Article: Fe65 is a major intracellular APP-binding protein. We show that Fe65 is a transcription factor, whose nuclear translocation and thus transcriptional capacity is regulated by APP cleavage.
- Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton
Summary: The ER–mitochondria tether maintained by MFN2 fine-tunes Rac activation to regulate neutrophil adhesive migration and adhesion to endothelial cells under shear stress.
- Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2
Summary: The interaction of the signal integrators AGS3 and DVL2 is regulated by protein phosphorylation, subcellular distribution, and a cell-surface G-protein-coupled receptor.
- The role of the α-tubulin acetyltransferase αTAT1 in the DNA damage response
Summary: The α-tubulin acetyltransferase αTAT1 is involved in DNA damage checkpoints and DNA repair through its acetyltransferase activity.
- Frustration of endocytosis potentiates compression-induced receptor signaling
Highlighted Article: Cancer cells subjected to compressive stress experience frustration of clathrin-mediated endocytosis which, in turn, leads to enhanced receptor signaling.
- RACK1 regulates centriole duplication through promoting the activation of polo-like kinase 1 by Aurora A
Summary: The BRCA1-interacting protein RACK1 regulates centriole duplication by acting as a scaffold protein for the phosphorylation of polo-like kinase 1 by Aurora A.
This issue
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2020 at The Company of Biologists
Despite the challenges of 2020, we were able to bring a number of long-term projects and new ventures to fruition. While we look forward to a new year, join us as we reflect on the triumphs of the last 12 months.
Mole – The Corona Files
"This is not going to go away, 'like a miracle.' We have to do magic. And I know we can."
Mole continues to offer his wise words to researchers on how to manage during the COVID-19 pandemic.
Cell scientist to watch – Christine Faulkner
In an interview, Christine Faulkner talks about where her interest in plant science began, how she found the transition between Australia and the UK, and shares her thoughts on virtual conferences.
Read & Publish participation extends worldwide
“The clear advantages are rapid and efficient exposure and easy access to my article around the world. I believe it is great to have this publishing option in fast-growing fields in biomedical research.”
Dr Jaceques Behmoaras (Imperial College London) shares his experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 60 institutions in 12 countries taking part – find out more and view our full list of participating institutions.
JCS and COVID-19
For more information on measures Journal of Cell Science is taking to support the community during the COVID-19 pandemic, please see here.
If you have any questions or concerns, please do not hestiate to contact the Editorial Office.