RESEARCH HIGHLIGHTS
STICKY WICKETS
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
- p63-related signaling at a glance
Summary: A review of the signaling cascades regulating and regulated by the different isoforms of the p53-related transcription factor p63, as well the role of p63 in disease.
REVIEWS
- Microautophagy – distinct molecular mechanisms handle cargoes of many sizes
Summary: Microautophagy is a versatile and conserved type of autophagy. Here, recent progress is reviewed that allows fission-type and fusion-type microautophagy to be distinguished, thus providing a new conceptual framework.
- Bring it back, bring it back, don't take it away from me – the sorting receptor RER1
Summary: In this Review we provide an overview of the early secretory pathway protein RER1, which cycles between cis-Golgi and ER, returning ER-resident proteins and unassembled subunits of multimeric complexes back to the ER.
RESEARCH ARTICLES
- Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas
Highlighted Article: Using GFP-tagged β-tubulin, we show that most of the tubulin required for axonemal assembly enters Chlamydomonas cilia by diffusion rather than by intraflagellar transport.
- Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure
Highlighted Article: A regulatory circuit maintaining intracellular amino acid homeostasis is revealed by studies of yeast growing under high hydrostatic pressure, with a critical role identified for the EGOC–Pib2–TORC1 complex.
- The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.
- LFA-1 signals to promote actin polymerization and upstream migration in T cells
Highlighted Article: Inflammatory responses require leukocyte migration along the vascular wall. We show that signaling from β2, but not β1, integrins induces cytoskeletal changes needed for upstream migration under shear flow.
- Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein
Highlighted Article: Fe65 is a major intracellular APP-binding protein. We show that Fe65 is a transcription factor, whose nuclear translocation and thus transcriptional capacity is regulated by APP cleavage.
- Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton
Summary: The ER–mitochondria tether maintained by MFN2 fine-tunes Rac activation to regulate neutrophil adhesive migration and adhesion to endothelial cells under shear stress.
- Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2
Summary: The interaction of the signal integrators AGS3 and DVL2 is regulated by protein phosphorylation, subcellular distribution, and a cell-surface G-protein-coupled receptor.
- The role of the α-tubulin acetyltransferase αTAT1 in the DNA damage response
Summary: The α-tubulin acetyltransferase αTAT1 is involved in DNA damage checkpoints and DNA repair through its acetyltransferase activity.
- Frustration of endocytosis potentiates compression-induced receptor signaling
Highlighted Article: Cancer cells subjected to compressive stress experience frustration of clathrin-mediated endocytosis which, in turn, leads to enhanced receptor signaling.
- RACK1 regulates centriole duplication through promoting the activation of polo-like kinase 1 by Aurora A
Summary: The BRCA1-interacting protein RACK1 regulates centriole duplication by acting as a scaffold protein for the phosphorylation of polo-like kinase 1 by Aurora A.
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JCS and COVID-19
For more information on measures Journal of Cell Science is taking to support the community during the COVID-19 pandemic, please see here.
If you have any questions or concerns, please do not hestiate to contact the Editorial Office.
Final week to submit to our next special issue!
The deadline for submissions for our next special issue on Cell Biology of Host-Pathogen Interactions is next Tuesday, 15 September. The issue will be guest edited by Derek Walsh (Northwestern University, USA) – find out more.
Cell scientist to watch – Yanlan Mao
Yanlan Mao, recipient of the 2020 Women in Cell Biology Early Career Award Medal from the British Society for Cell Biology (BSCB), talks about her reasons for entering science, the development of biophysics as her research interest, how she found starting her own lab and the experience of COVID-19 as a female PI.
The Corona Files
“Compared to the vast majority of the population, you qualify as an expert – able to critically examine emerging data and communicate it to others.”
Our resident insectivore, Mole, continues his latest series – The Corona Files. Catch up on Mole’s weekly musings on how COVID-19 is changing the landscape for researchers.
A new LSFM blog series starts on FocalPlane
Elisabeth Kugler and Emmanuel Reynaud take to FocalPlane for the first in their five-part series on Light Sheet Fluorescence Microscopy (LSFM). In part one, find out what topics the series will cover and catch up on the basics of LSFM.