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December, 2020; 133 (24)

RESEARCH HIGHLIGHTS

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    Yeast malate dehydrogenase catches a ride to the peroxisome
    Journal of Cell Science 2020 133: e2401
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    Dynamic chromatin changes at the nuclear periphery during cell differentiation
    Journal of Cell Science 2020 133: e2402
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    CD301: a C-type lectin driving macrophage cell fusion during inflammation
    Journal of Cell Science 2020 133: e2403
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    Sealing the nuclear envelope: Heh1 alternative splicing regulates ESCRT recruitment
    Journal of Cell Science 2020 133: e2404
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    Stop ‘Start’: repressing cell cycle entry during cell integrity stress
    Journal of Cell Science 2020 133: e2405

STICKY WICKETS

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    Corona XXVII – see rule #1
    Mole
    Journal of Cell Science 2020 133: jcs257741 doi: 10.1242/jcs.257741 Published 17 December 2020
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    Corona XXVIII – the Rashomon gate
    Mole
    Journal of Cell Science 2020 133: jcs258202 doi: 10.1242/jcs.258202 Published 24 December 2020

OBITUARY

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    Remembering Angelika Amon (1967–2020)
    Andreas Hochwagen, Luke E. Berchowitz
    Journal of Cell Science 2020 133: jcs257444 doi: 10.1242/jcs.257444 Published 15 December 2020

FIRST PERSON

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    First person – Patricia Joyce Brooks
    Journal of Cell Science 2020 133: jcs258004 doi: 10.1242/jcs.258004 Published 23 December 2020
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    First person – Carlos Martín-Rodríguez
    Journal of Cell Science 2020 133: jcs258012 doi: 10.1242/jcs.258012 Published 23 December 2020
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    First person – Matías Capella
    Journal of Cell Science 2020 133: jcs258020 doi: 10.1242/jcs.258020 Published 21 December 2020

CELL SCIENTISTS TO WATCH

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    Cell scientist to watch – Christine Faulkner
    Journal of Cell Science 2020 133: jcs256826 doi: 10.1242/jcs.256826 Published 15 December 2020

CELL SCIENCE AT A GLANCE

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    Tumour-directed microenvironment remodelling at a glance
    Sarah T. Boyle, M. Zahied Johan, Michael S. Samuel
    Journal of Cell Science 2020 133: jcs247783 doi: 10.1242/jcs.247783 Published 22 December 2020

    Summary: An outline of the processes by which epithelial tumours regulate their tumour microenvironment, and how new insights into tumour–microenvironment interactions have led to ideas on targeting it as treatments.

REVIEWS

  • Open Access
    The journey of Ca2+ through the cell – pulsing through the network of ER membrane contact sites
    Tom Cremer, Jacques Neefjes, Ilana Berlin
    Journal of Cell Science 2020 133: jcs249136 doi: 10.1242/jcs.249136 Published 29 December 2020

    Summary: Traveling through the ER, Ca2+ is transported towards membrane contact sites with mitochondria or endolysosomes, where it plays key roles in the regulation of essential organellar biology, which are reviewed here.

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    Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis
    Oscar M. J. A. Stassen, Tommaso Ristori, Cecilia M. Sahlgren
    Journal of Cell Science 2020 133: jcs250738 doi: 10.1242/jcs.250738 Published 21 December 2020

    Summary: This Review presents evidence that Notch signaling is directly and indirectly mechanosensitive, and discusses engineered and computational approaches to help unravel its complex dynamics.

RESEARCH ARTICLES

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    Sec71 separates Golgi stacks in Drosophila S2 cells
    Syara Fujii, Kazuo Kurokawa, Tatsuya Tago, Ryota Inaba, Arata Takiguchi, Akihiko Nakano, Takunori Satoh, Akiko K. Satoh
    Journal of Cell Science 2020 133: jcs245571 doi: 10.1242/jcs.245571 Published 29 December 2020

    Summary: Golgi stacks are scattered in the cytoplasm of Drosophila cells. Sec71 is required for separating Golgi stacks, as its impairment, for example, through brefeldin A (BFA) treatment, produces Golgi aggregations termed BFA bodies.

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    Mitochondria control mTORC1 activity-linked compartmentalization of eIF4E to regulate extracellular export of microRNAs
    Susanta Chatterjee, Yogaditya Chakrabarty, Saikat Banerjee, Souvik Ghosh, Suvendra N. Bhattacharyya
    Journal of Cell Science 2020 133: jcs250241 doi: 10.1242/jcs.250241 Published 29 December 2020

    Summary:Mitochondrial activity and tethering with the ER are linked to compartmentalization of the translation initiation factor eIF4E to the polysomes, which controls miRNA-mediated repression and miRNA export.

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    A novel mitosis-specific Cep215 domain interacts with Cep192 and phosphorylated Aurora A for organization of spindle poles
    Ryoko Kuriyama, Cody R. Fisher
    Journal of Cell Science 2020 133: jcs240267 doi: 10.1242/jcs.240267 Published 29 December 2020

    Summary: A mitosis-specific centrosome-targeting domain of Cep215 binds Cep192 and phosphorylated Aurora A to play a role in maintaining the structural integrity of spindle poles during mitosis.

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    Retromer retrieves the Wilson disease protein ATP7B from endolysosomes in a copper-dependent manner
    Santanu Das, Saptarshi Maji, Ruturaj, Indira Bhattacharya, Tanusree Saha, Nabanita Naskar, Arnab Gupta
    Journal of Cell Science 2020 133: jcs246819 doi: 10.1242/jcs.246819 Published 24 December 2020

    Summary: The Wilson disease protein ATP7B utilizes lysosomal exocytosis to export excess copper in hepatocytes. The retromer complex retrieves ATP7B from endolysosomes and recycles it back to the trans-Golgi network.

  • Open Access
    Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease
    Thuy N. Vien, Leo C. T. Ng, Jessica M. Smith, Ke Dong, Matteus Krappitz, Vladimir G. Gainullin, Sorin Fedeles, Peter C. Harris, Stefan Somlo, Paul G. DeCaen
    Journal of Cell Science 2020 133: jcs255562 doi: 10.1242/jcs.255562 Published 24 December 2020

    Summary: A refutation of a common hypothesis regarding Ca2+ control mechanisms of polycystin-2 – a primary cilia ion channel, the dysregulation of which causes autosomal dominant polycystic kidney disease.

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    EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration
    Afsheen Banisadr, Mariam Eick, Pranjali Beri, Alison D. Parisian, Benjamin Yeoman, Jesse K. Placone, Adam J. Engler, Frank Furnari
    Journal of Cell Science 2020 133: jcs247189 doi: 10.1242/jcs.247189 Published 24 December 2020

    Summary: Constitutively active and truncated EGFR transcriptionally represses integrins via a SHC–MEK signaling axis, and communicates with neighboring cells through TNFα to promote cooperative invasion.

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    TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation
    Carlos Martín-Rodríguez, Minseok Song, Begoña Anta, Francisco J. González-Calvo, Rubén Deogracias, Deqiang Jing, Francis S. Lee, Juan Carlos Arevalo
    Journal of Cell Science 2020 133: jcs247841 doi: 10.1242/jcs.247841 Published 23 December 2020

    Summary: USP8 interacts with and deubiquitylates TrkB neurotrophin receptors, regulating levels of both total and activated receptors and BDNF-dependent differentiation of hippocampal neurons.

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    CD301 mediates fusion in IL-4-driven multinucleated giant cell formation
    Patricia J. Brooks, Yongqiang Wang, Marco A. Magalhaes, Michael Glogauer, Christopher A. McCulloch
    Journal of Cell Science 2020 133: jcs248864 doi: 10.1242/jcs.248864 Published 23 December 2020

    Highlighted Article: CD301, a C-type lectin domain family 10 member, is driven by IL-4 and mediates macrophage fusion for the formation of multinucleated giant cells.

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    ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing
    Matías Capella, Lucía Martín Caballero, Boris Pfander, Sigurd Braun, Stefan Jentsch
    Journal of Cell Science 2020 133: jcs250688 doi: 10.1242/jcs.250688 Published 21 December 2020

    Highlighted Article: Heh1-S, the inner nuclear membrane protein resulting from Hub1-mediated splicing of HEH1 pre-mRNA, contributes to nuclear envelope maintenance by preventing excessive recruitment of the ESCRT adaptor Chm7.

  • Open Access
    The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress
    Ester Méndez, Mercè Gomar-Alba, M. Carmen Bañó, Manuel Mendoza, Inma Quilis, J. Carlos Igual
    Journal of Cell Science 2020 133: jcs251413 doi: 10.1242/jcs.251413 Published 21 December 2020

    Highlighted Article: Cells can use the interplay between functionally redundant but differentially regulated cell-cycle repressors in order to confer new repression capabilities and to respond to specific cellular conditions.

  • Open Access
    A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast
    Shiran Gabay-Maskit, Luis Daniel Cruz-Zaragoza, Nadav Shai, Miriam Eisenstein, Chen Bibi, Nir Cohen, Tobias Hansen, Eden Yifrach, Nofar Harpaz, Ruth Belostotsky, Wolfgang Schliebs, Maya Schuldiner, Ralf Erdmann, Einat Zalckvar
    Journal of Cell Science 2020 133: jcs244376 doi: 10.1242/jcs.244376 Published 17 December 2020

    Highlighted Article: Yeast Mdh2 is dually localized to the cytosol and peroxisomes, and is targeted to peroxisomes via association with Mdh3 and a Pex5-dependent piggybacking mechanism.

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    Sequential peripheral enrichment of H2A.Zac and H3K9me2 during trophoblast differentiation in human embryonic stem cells
    Georgia Rose Kafer, Yoshihisa Tanaka, Regina Rillo-Bohn, Eiko Shimizu, Kouichi Hasegawa, Peter M. Carlton
    Journal of Cell Science 2020 133: jcs245282 doi: 10.1242/jcs.245282 Published 16 November 2020

    Highlighted Article: As early as 12 hours after embryonic stem cells begin differentiating to trophoblasts, acetylated H2A.Z becomes enriched at the nuclear periphery; we find that loss of H2A.Z acetylation is followed sequentially by enrichment of dimethylated H3K9.

TOOLS AND RESOURCES

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    Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane
    Domingos Castro, Vanessa Nunes, Joana T. Lima, Jorge G. Ferreira, Paulo Aguiar
    Journal of Cell Science 2020 133: jcs252254 doi: 10.1242/jcs.252254 Published 21 December 2020

    Summary: Development of a new image analysis toolbox called Trackosome and its use to study nuclear envelope oscillations during early mitosis and correlations between the trajectories of the centrosomes.

CORRECTION

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    Correction: HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance
    Yaya Wang, Diana Argiles-Castillo, Emma I. Kane, Anning Zhou, Donald E. Spratt
    Journal of Cell Science 2020 133: jcs258087 doi: 10.1242/jcs.258087 Published 21 December 2020
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Journal of Cell Science: 133 (24)
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  • CELL SCIENCE AT A GLANCE
  • REVIEWS
  • RESEARCH ARTICLES
  • TOOLS AND RESOURCES
  • CORRECTION

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  • Open Access

    SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72

    Mirjana Malnar, Boris Rogelj
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    Calcium elevations disrupt interactions between intraflagellar transport and the flagella membrane in Chlamydomonas

    Cecile Fort, Peter Collingridge, Colin Brownlee, Glen Wheeler
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    Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells

    Fumiko Matsukawa Usami, Masaki Arata, Dongbo Shi, Sanae Oka, Yoko Higuchi, Fadel Tissir, Masatoshi Takeichi, Toshihiko Fujimori
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    Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of C. elegans primary spermatocytes

    Xiangchuan Wang, Dandan Zhang, Cunni Zheng, Shian Wu, Michael Glotzer, Yu Chung Tse
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    An endometrial organoid model of Chlamydia-epithelial and immune cell interactions

    Lee Dolat, Raphael H. Valdivia
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