Cover image

Cover: Growth-arrested mammalian cells display reduced mitochondrial dynamics and a concomitant decrease in mitochondrial association with the endoplasmic reticulum. This de-tethering of these organelles ultimately causes reduced compartment-specific activity of mTORC1 complex, leading to polysomal retention and reduced export of miRNAs. The 3D rendering of mitochondrial structures from a proliferating HeLa cell (yet to reach growth arrest) shown here depicts the highly branched mitochondrial network in a gradient of dark pink to off-white according to individual strand lengths. The blue to green colour marks the degree of association of the mitochondria and endoplasmic reticulum at specific points. See article by S. Chatterjee et al. (jcs250241).