This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section. More information on our continuous publication model can be found here.
REVIEW
- Vacuolar escape of foodborne bacterial pathogens
Summary: A review of common mechanisms of how intracellular pathogens escape from the lumen of vacuoles in infected host cells. A new mechanism based on oxidation of vacuolar membranes is proposed.
SHORT REPORT
- Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages
Summary: High-content real-time imaging of L. amazonensis-infected pyroptotic macrophages reveals surface exposure of virulent amastigotes that are retained through attachment to the parasitophorous vacuole membrane.
RESEARCH ARTICLES
- Foot-and-mouth disease virus induces PERK-mediated autophagy to suppress the antiviral interferon response
Summary: Foot-and-mouth disease virus infection induces ER stress and the PERK-mediated UPR, which activates autophagic flux to promote virus multiplication by affecting antiviral interferon production.
- Proteomic and mechanistic dissection of the poxvirus-customized ribosome
Summary: Through ribosome isolation and mass spectrometry approaches, we characterize novel modifications to ribosomal proteins during poxvirus infection.
- Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation
Summary: Dynamic localisation of the NDC80 protein complex, a kinetochore marker, during proliferative stages of the malaria parasite life cycle reveals unique modes of chromosome segregation.
- Protein tyrosine phosphatase 1B is involved in efficient type I interferon secretion upon viral infection
Summary: PTP1B specifically promotes the secretion of type I IFNs independently of its phosphatase activity, but requiring its proper localization to the ER membrane.
- Convergent Met and voltage-gated Ca2+ channel signaling drives hypermigration of Toxoplasma-infected dendritic cells
Summary: The parasite T. gondii hijacks the Ras–Erk, Met and Ca2+ signaling machinery to control the migration of immune cells and promote its own dissemination.
- A function of profilin in force generation during malaria parasite motility that is independent of actin binding
Summary: Biochemical, computational, reverse genetic and biophysical approaches show that a divergent motif of profilin has a role in Plasmodium sporozoite migration, which is important for malaria transmission.
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Author choices on Journal of Cell Science: how ‘open’ are we to Open Access
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First Person interviews – Shivali Rawat, Julien Pernier, Jana Jentzsch
In issue 18, hear from first authors Shivali Rawat, Julien Pernier and Jana Jentzsch as they discuss their research, life away from the bench and their experience of being an early-career researcher.
The Corona Files
"We know that we desperately need a vaccine for the virus that has caused this Terrible Pandemic."
Our resident insectivore, Mole, continues his latest series – The Corona Files. Catch up on Mole's weekly musings on how COVID-19 is changing the landscape for researchers.
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