ABSTRACT
All intracellular pathogens must escape (egress) from the confines of their host cell to disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole or in a cyst, and must undergo egress at four distinct phases during its complex life cycle, each time disrupting, in a highly regulated manner, the membranes or cyst wall that entrap the parasites. This Cell Science at a Glance article and accompanying poster summarises our current knowledge of the morphological features of egress across the Plasmodium life cycle, the molecular mechanisms that govern the process, and how researchers are working to exploit this knowledge to develop much-needed new approaches to malaria control.
Footnotes
Competing interests
The authors declare no competing or financial interests.
Funding
This research was funded in part by the Wellcome Trust. The work was also supported by funding to M.J.B. from the Francis Crick Institute (https://www.crick.ac.uk/), which receives its core funding from Cancer Research UK (FC001043; https://www.cancerresearchuk.org), the UK Medical Research Council (FC001043; https://www.mrc.ac.uk/), and the Wellcome Trust (FC001043; https://wellcome.ac.uk/). M.S.Y.T. was in receipt of a Francis Crick PhD studentship, as well as funding from the Francis Crick Idea to Innovation (i2i) programme (grant P2019-0015). The work was also supported by Wellcome ISSF2 funding to the London School of Hygiene & Tropical Medicine.
Cell science at a glance
A high-resolution version of the poster and individual poster panels are available for downloading at http://jcs.biologists.org/lookup/doi/10.1242/jcs.257345.supplemental
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