PT  - JOURNAL ARTICLE
AU  - Kelly, R. B.
AU  - Bonzelius, Frank
AU  - Cleves, Ann
AU  - Clift-O’Grady, Lois
AU  - Grote, Eric
AU  - Herman, Gary
TI  - Biogenesis of synaptic vesicles
AID  - 10.1242/jcs.1993.Supplement_17.12
DP  - 1993 Dec 01
TA  - Journal of Cell Science
PG  - 81--83
VI  - 1993
IP  - Supplement 17
4099  - http://jcs.biologists.org/content/1993/Supplement_17/81.short
4100  - http://jcs.biologists.org/content/1993/Supplement_17/81.full
SO  - J. Cell Sci.1993 Dec 01; 1993
AB  - The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and Storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.