PT  - JOURNAL ARTICLE
AU  - Vuolo, Laura
AU  - Stevenson, Nicola L.
AU  - Mukhopadhyay, Aakash G.
AU  - Roberts, Anthony J.
AU  - Stephens, David J.
TI  - Cytoplasmic dynein-2 at a glance
AID  - 10.1242/jcs.240614
DP  - 2020 Mar 15
TA  - Journal of Cell Science
PG  - jcs240614
VI  - 133
IP  - 6
4099  - http://jcs.biologists.org/content/133/6/jcs240614.short
4100  - http://jcs.biologists.org/content/133/6/jcs240614.full
SO  - J. Cell Sci.2020 Mar 15; 133
AB  - Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abnormalities. Long-standing questions include how the dynein-2 complex is assembled, regulated, and switched between active and inactive states. A combination of model organisms, in vitro cell biology, live-cell imaging, structural biology and biochemistry has advanced our understanding of the dynein-2 motor. In this Cell Science at a Glance article and the accompanying poster, we discuss the current understanding of dynein-2 and its roles in ciliary assembly and function.