PT - JOURNAL ARTICLE AU - Vuolo, Laura AU - Stevenson, Nicola L. AU - Mukhopadhyay, Aakash G. AU - Roberts, Anthony J. AU - Stephens, David J. TI - Cytoplasmic dynein-2 at a glance AID - 10.1242/jcs.240614 DP - 2020 Mar 15 TA - Journal of Cell Science PG - jcs240614 VI - 133 IP - 6 4099 - http://jcs.biologists.org/content/133/6/jcs240614.short 4100 - http://jcs.biologists.org/content/133/6/jcs240614.full SO - J. Cell Sci.2020 Mar 15; 133 AB - Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abnormalities. Long-standing questions include how the dynein-2 complex is assembled, regulated, and switched between active and inactive states. A combination of model organisms, in vitro cell biology, live-cell imaging, structural biology and biochemistry has advanced our understanding of the dynein-2 motor. In this Cell Science at a Glance article and the accompanying poster, we discuss the current understanding of dynein-2 and its roles in ciliary assembly and function.