Table 1.

Examples of Hsp90 and Hsp70 co-chaperones, interacting molecules and cellular function

ChaperoneCellular functionCo-chaperonePreferred interaction partnerReferences
Hsp90Signal transductionCdc37Kinases Cutforth and Rubin, 1994; Gerber et al., 1995; Grammatikakis et al., 1999; Kimura et al., 1997; Perdew et al., 1997; Schutz et al., 1997
Hormone responsePP5 (TPR)Glucocorticoid receptor Silverstein et al., 1997
Immunophilins (TPR):Hormone receptors:
Cyp40Oestrogen receptor Silverstein et al., 1997
FKBP52Steroid receptor Davies et al., 2002; Silverstein et al., 1997
FKBP51Progesteron/ glucocorticoid receptor Davies et al., 2002; Silverstein et al., 1997
Cell deathUnknownApaf-1 Pandey et al., 2000
Stress responseUnknownHSF-1 Zou et al., 1998
Complex assemblyp23Chaperone complex Young et al., 1998
HopChaperone complex Prapapanich et al., 1996
Hsp70Signal transductionBag1Raf-1 kinase Wang et al., 1996
Bag1Growth factor receptors Bardelli et al., 1996
Hormone responseBag1Hormone receptors Zeiner and Gehring, 1995
HipSteroid receptor Prapapanich et al., 1996
Cell deathBag1Bcl-2 Takayama et al., 1995
UnknownApaf-1 Beere et al., 2000
Stress responseUnknownHSF-1 Abravaya et al., 1992
Complex assemblyHopChaperone complex Chen and Smith, 1998
Hdj-1Chaperone complex Caplan et al., 1995; Dittmar et al., 1998; Kosano et al., 1998