Table 1.

mRNA and protein profiles for clock genes in Drosophila and mouse

Drosophila dClockcyclecryptochromeperiod
Peripheral
Whole headZT/CT23-05(×4)Constitutive04-10(×2)14-15 (×10)
ZT/CT24-05 (×4)ConstitutiveAccumulates in the dark20-22 (×10)
Mammal mClock Npas2 Mop4 Bmal1 Mop3 mCry1 mCry2 mPer1 mPer2
Peripheral
VasculatureCTConstitutive01-05 (×4)23-05 (×5)23-04 (×4)n/dn/d13-17 (×10)
HeartZT21-03 (×1.5)Low/absent22-03 (×19)15-24 (×3)12-21 (×3)11-13 (×5)12-17 (×8)
CTn/dn/dn/dn/d09-12 (mod)12-15 (high)
ForebrainCTLow/absentExpressed, cycling n/d22-02 (high)14-24 (low)n/d10-15 (mod)14-18 (high)
KidneyCTn/dLow/absentn/dn/dn/d09-15 (mod)12-15 (high)
Skeletal muscleCTn/dn/dn/d18-21 (×2)06-12 (×1.5) *09-15 (mod)12-18 (high)
LiverZT/CT21-03 (×2)Low/absent21-03 (×15)14-17 (×2)08-10 (×2) *08-16 (×20)10-18 (×20)
CTBi-phasic?n/d15-03 (×4)21-24 (×3)15-21 (×2)15-18 (×10)15-18 (×10)
Central
SuprachiasmaticZT/CTConstitutiveLow/absent13-21 (×1.5)08-16 (×2)08-16 (×2) *04-08 (×10) 06-12 (×15)
nucleus (SCN)CTn/dn/d13-21 (×2)12-18 (×2)12-16 (×2)10-14 (×10)10-14 (×10)