Table 1.

PCNA-interacting proteins (PIPs) in DNA replication, DNA repair and cell cycle control

PIPFunctionReferences
Pol δDNA replication and repairZhang et al., 1999; Zhou et al., 1997; Ducoux et al., 2001
Pol ϵDNA replicationand repairEissenberg et al., 1997; Dua et al., 2002
RF-CDNA replication and repair Fotedar et al., 1996
DNA ligase IDNA replication and repair Levin et al., 1997
Fen1DNA replication and repair Warbrick et al., 1997
Topo IDNA replication and repair Loor et al., 1997
Topo IIαDNA replication and repair Niimi et al., 2001
MLH1, MSH 2/3/6Mismatch DNA repairUmar et al., 1996; Clark et al., 2000
XP-G endonucleaseNucleotide excision repair Gary et al., 1997
WRN helicaseDouble strand breaks DNA repair; linked to the Werner Syndrome disease Lebel et al., 1999
UBC9SUMOilation Hoege et al., 2002
AP-endonucleases APN1, APN2Base excision repairDianova et al., 2001; Unk et al., 2002
Uracil-DNA glycosylaseBase excision repair Krokan et al., 2001
Pol βBase excision repair Kedar et al., 2002
Pol ηTranslesion synthesis; linked to the XP-V disease Haracska et al., 2001a
Pol ιTranslesion synthesis Haracska et al., 2001b
Pol κTranslesion synthesis Haracska et al., 2002
Pol λTranslesion synthesis Maga et al., 2002
Cyclin/CDKsCell cycle controlXiong et al., 1992; Zhang et al., 1993
p21Cell cycle control Waga et al., 1994c