Table 1.

Comparison of CAM-mediated endocytosis with phagocytosis and macropinocytosis

CR-mediated phagocytosisFcR-mediated phagocytosisMacropinocytosisCAM-mediated endocytosisDistinct from
Internalize particles >1 μmYesYesYesNoCFM
Receptor clustering+*+-+M
Dynamin-2++-+M
NHE--++CF
PKC++++n
Actin++++n
Actin cup+++-CFM
Microtubules+-+-CM
Src kinase-+++C
PI-3 kinase+++-CFM
Rho kinase+-?+F
  • Table adapted from Caron and Hall (Caron and Hall, 2001) and expanded. For references to specific elements, see text.

  • * +, required for uptake; -, not required for uptake; ?, unknown.

  • C, distinct from complement receptor (CR)-mediated phagocytosis; F, distinct from FcR-mediated phagocytosis; M, distinct from macropinocytosis; n, none, common to all listed pathways.