Table 1.

Rearrangement of selected centromeric loci and coding sequences in A549 cells treated and not treated with TSA

Locus Untreated TSA-treated
Centromeric heterochromatin
   9cen–9cen/R 78.4±0.7% 83.3±0.8%*
   Nuclear centre–9cen/R 60.8±0.5% 62.3±0.5%*
   8cen–8cen/R 80.6±1.3% 91.6±1.9%*
   Nuclear centre–8cen/R 61.0±0.8% 67.1±1.0%*
   10cen–10cen/R 72.8±1.3% 82.8±1.6%*
   Nuclear centre–10cen/R 55.8±0.8% 62.9±1.2%*
Coding sequences
   MYC–MYC/R 91.9±1.4% 84.9±1.2%*
   Nuclear centre–MYC/R 71.1±0.9% 68.8±0.5%*
   CCND1–CCND1 76.0±0.9% 73.3±1.0%
   Nuclear centre–CCND1 60.5±0.4% 54.7±0.7%*
  • The distances of the given genetic element from the nuclear centre and distances between homologous genetic elements were analyzed.

    Statistically significant at *P<0.05.