Table 2.

Genes differentially expressed in human skin fibroblasts in UVB-induced SIPS

Gene Name UVB/CTL Function GenBank
IGF-BP3 insulin growth factor binding protein 3 ↑ 2,7 growth factor X64875
HSP70 heat shock 70 kD protein 1 ↑ 2,5 defense system AB023420
HMOX heme-oxygenase ↑ 2,4 defense system NM_002133
IL-1B interleukin 1 beta ↑ 2,4 cytokine M15330
OSTE osteonectin ↑ 2,4 extracellular matrix NM_003118
ODC ornithine decarboxylase 1 ↑ 2,3 cell cycle NM_002539
HSP90A heat shock 90 kD protein 1 alpha ↑ 2,3 defense system X15183
COL1A1 collagen 1 alpha-1 ↑ 2,2 extracellular matrix NM_000088
MAX MAX protein ↑ 2,2 cell cycle NM_002382
CTGF connective tissue growth factor ↑ 2,1 cell cycle U14750
PCNA proliferating cell nuclear antigen ↑ 2,1 control of DNA replication NM002592
TPA plasminogen activator tissue ↑ 2,1 extracellular matrix NM_000930
CCND-1 cyclin D1 ↑ 2,1 cell cycle NM_053056
MMP-1 matrix metalloproteinase 1 ↑ 2,1 degradation of extracellular matrix NM_002421
MT2A metallothionein 2A ↑ 2 defense system V00594
APO J apolipoprotein J ↑ 2 defense system J02908
COL3A1 collagen 3 alpha-1 ↑ 2 extracellular matrix NM_000090
HSP40 heat shock 40 kD protein 1 ↑ 2 defense system D49547
MEK-1 mitogen activated protein kinase kinase 1 ↑ 2 cell cycle L11284
p21 cyclin dependent kinase inhibitor 1A ↑ 1,9 cell cycle U03106
NRG-1 neuregulin ↑ 1,9 cell cycle M94165
FN1 fibronectin ↑ 1,9 extracellular matrix X02761
TGFβRII transforming growth factor-beta receptor II ↑ 1,9 growth factor D50685
Il-11 interleukin 11 ↑ 1,8 cytokine NM_000641
MMP-2 matrix metalloproteinase 2 ↑ 1,8 degradation of extracellular matrix NM_004530
ANX-1 annexin 1 ↑ 1,8 anti-inflammatory NM_000700
HSP70B heat shock 70 kD protein 6 ↑ 1,8 defense system NM_002155
IGF-BP5 insulin growth factor binding protein 5 ↑ 1,8 growth factor M65062
JNK-2 mitogen activated protein kinase 9 ↑ 1,8 defense system U09759
CANX calnexin ↑ 1,8 cell cycle NM_001746
HSP27 heat shock 27 kD protein 1 ↑ 1,8 defense system AB020027
EF1A eucaryotic translation elongation factor-alpha ↑ 1,7 protein synthesis AY043301
PRX VI peroxiredoxin VI ↑ 1,7 defense system NM_004905
MDM2 MDM2 ↑ 1,7 cell cycle NM_002392
GPX glutathion peroxidase ↑ 1,6 defense system M21304
H2BS histone 2B member B/S consensus ↑ 1,6 cell cycle NM_080593
CCNH cyclin H ↑ 1,6 cell cycle NM_001239
FMOD fibromodulin ↓ 0,6 extracellular matrix NM_002023
ICAM-1 intracellular adhesion molecule 1 ↓ 0,3 extracellular matrix J031032
  • Total mRNA was collected at 72 hours after a series of 10 UVB stresses at 250 mJ/cm2.