Table 2.

Cortactin phosphorylation sites shared between species

Residue Human Frog Fish Fly Sponge
NTA S11 + + + - -
T13 - - - - -
T24 + + + + +
Repeat S135 + + + + +
S150 + + + + +
S172 + + - + -
T182 + + + - -
S209 + + + - -
S282 + - + - +
S283 - - + - +
HPR S322 + - + - -
[T323] + - + - -
S345 + + + - -
S348 + + + - -
S407 - - - - -
[S417] + - - - -
[S418] + + - - -
[Y421] + + - - -
S454 + - - - -
T468 - - - - -
Y475 + + - - -
  • The sequence of mouse cortactin was compared to the cortactin sequences from human, frog (Xenopus laevis), fish (Danio rerio), fly (Drosophila melanogaster) and sponge (Suberites domuncula) (van Rossum et al., 2005). +, phosphorylated amino acids that are conserved; -, phosphorylated amino acids that are not conserved. Phosphorylation sites on residues in brackets could not be specified unambiguously.