Table 1.

Summary of proteins involved in budding yeast karyogamy

Protein Metazoan ortholog Nuclear orientation Shmoo tip attachment Frequency of nuclear congression or karyogamy*
Kip2p Kinesin-7 + Detach on MT shortening 100%
Kar9p APC NA 50%
Myo2p Type V Myosin ? ?
Bik1p CLIP-170 + Detach on MT shortening 20%
Bim1p EB1 NA ∼1%
Kar3p Kinesin-14 + Detach on MT shortening <1%
  • NA, not applicable; ?, unknown

  • * References for phenotypes: Miller et al., 1998, Meluh and Rose, 1990; Molk et al., 2006, Schwartz et al., 1997

  • Weak homology to adenomatous polyposis coli protein