Table 1.

The Rab family

Rab Localization Function References
(1) Rab23 Rab23 Plasma membrane and endosomes Trafficking of sonic hedgehog signaling components; embryogenesis; ciliary trafficking Evans et al., 2003
(2) Rab29, Rab32, Rab38, Rab7L1
Rab32 Perinuclear vesicles; mitochondria Post-Golgi trafficking of melanogenic enzymes; binds PKA and regulates mitochondrial dynamics Alto et al., 2002; Wasmeier et al., 2006
Rab38 Tyrosinase-positive vesicles Post-Golgi biogenesis of melanosomes Wasmeier et al., 2006
(3) RabL2, RabL3, RabL5
(4) Ran
Ran Nucleus, cytoplasm Nucleocytoplasmic transport Joseph, 2006
(5) Rab7, Rab7b, Rab9
Rab7, Rab7b Late endosomes, lysosomes Transport from early to late endosomes; lysosome biogenesis; b) transport to lysosomes, TLR4 signaling Feng et al., 2001; Bucci et al., 2000; Wang et al., 2007
Rab9a,b,c Late endosomes Lysosomal enzyme and cholesterol trafficking; late endosome to trans-Golgi transport Ganley et al., 2004; Lombardi et al., 1993; Narita et al., 2005
(6) Rab28, RabL4
(7) Rab34, Rab36
Rab34 Cell surface membrane ruffles, lysosomes Regulation of spatial distribution of lysosomes; Formation of macropinosomes Colucci et al., 2005; Sun and Endo, 2005; Sun et al., 2003; Wu et al., 2005
(8) Rab6, Rab41
Rab6a,a′,b,c (a,a′,b) Golgi, (b) ERGIC-53-positive vesicles and neuronal cell specific Retrograde transport; (a,b) Golgi to ER and intra-Golgi tranport, Golgi stress response (a′) endosome to Golgi transport; (c) multi-drug resistance regulation Jiang and Storrie, 2005; Martinez et al., 1994; Del Nery et al., 2006; Opdam et al., 2000; Shan et al., 2000
(9) Rab5, Rab17, Rab20, Rab21, Rab22a/Rab31, Rab24
Rab5a,b,c Clathrin coated vesicles, caveosomes, and early endosomes. Endocytosis, early endosome fusion, caveolar vesicle targeting to early endosomes; (a) EGF receptor activation; (b) neuroprotection Pelkmans et al., 2004; Barbieri et al., 2000; Arnett et al., 2004; Bucci et al., 1995
Rab17 Epithelial specific; apical recycling endosome Transport through apical recycling endosomes; polarized sorting Zacchi et al., 1998
Rab20 Epithelial specific; kidney dense apical tubules V-ATPase trafficking Curtis and Gluck, 2005
Rab21 Early endosomes Endocytosis of integrins, cell-extracellular matrix adhesion and motility Pellinen et al., 2006
Rab22a,b,c/Rab31 Early endosomes and trans-Golgi Biosynthetic pathway; (a) endosome to Golgi transport; phagosome maturation (b) trans-Golgi to endosome transport Kauppi et al., 2002; Mesa et al., 2001; Roberts et al., 2006; Rodriguez-Gabin et al., 2001
Rab24 Autophagosomes, nuclear inclusions Induction of autophagy, tyrosine phosphorylated Munafó and Colombo, 2002; Overmeyer and Maltese, 2005
(10) Rab18
Rab18 Dense apical tubules (kidney) and basolateral membrane (intestine); ER/lipid droplets; neuroendocrine secretory granules Formation of lipid droplets from ER; negative regulator of neuroendocrine secretion Lütcke et al., 1994; Ozeki et al., 2005; Vazquez-Martinez et al., 2007
(11) Rab2, Rab4, Rab11, Rab14, Rab25, Rab39, Rab42
Rab2a,b Endoplasmic reticulum ER to Golgi transport Tisdale et al., 1992
Rab4a,b,c Early and recycling endosomes Rapid endocytic recycling to plasma membrane; (a) adherens junction disassembly van der Sluijs et al., 1992; Mruk et al., 2007; Bottger et al., 1996
Rab11a,b (a) Golgi and recycling endosomes; (b) neuronal specific (a) Transport from Golgi to apical endocytic recycling endosomes; phagocytosis in macrophages; (b) Ca2+-dependent secretion Ullrich et al., 1996; Wilcke et al., 2000; Khvotchev et al., 2003
Rab14 Rough ER; Golgi/trans-Golgi and early endosomes Phagosome and early endosome fusion; trafficking between early endosomes and Golgi Junutula et al., 2004; Kyei et al., 2006; Proikas-Cezanne et al., 2006
Rab25 Epithelial specific; apical recycling endosome Transport of apical recycling endosomes Casanova et al., 1999; Wang et al., 2000
(12) Rab19, Rab30, Rab33, Rab43
Rab33a,b Medial Golgi Retrograde Golgi transport to ER Valsdottir et al., 2001
(13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab40
Rab1a,b Endoplasmic reticulum ER to Golgi transport Tisdale et al., 1992; Allan et al., 2000
Rab3a,b,c,d Synaptic and secretory vesicles. Regulated exocytosis; (a-d) Ca2+-dependent secretion and vesicle docking; dense-core vesicle docking to the plasma membrane (with Rab27) Rupnik et al., 2007; Schlüter et al., 2002; Tsuboi and Fukuda, 2006
Rab8a,b Golgi region, endosomes, dendrites, basolateral plasma membrane Trafficking between Golgi, endosomes and plasma membrane; cholesterol degradation; Extension of primary ciliary membrane (a) basolateral transport in epithelia and dendritic transport in neurons; (b) adherens junction assembly Nachury et al., 2007; Peränen et al., 1996; Chen et al., 2001; Chen and Wandinger-Ness, 2001; Hattula et al., 2006; Linder et al., 2007
Rab10 Golgi Polarized membrane transport from Golgi to basolateral membrane, may co-operate with Rab8 Babbey et al., 2006; Chen et al., 1993; Schuck et al., 2007
Rab12 Centrosomes Transport from cell periphery to perinuclear centrosomes Iida et al., 2005
Rab13 Tight junctions and endosomes Tight junction biogenesis Marzesco et al., 2002
Rab15 Early/sorting and recycling endosomes Trafficking through recycling endosomes; coordinates rapid and slow recycling; attenuates Rab5 function Elferink and Strick, 2005; Zuk and Elferink, 2000
(14) Rab26, Rab27, Rab37, Rab44, Rasef
Rab26 Secretory granules Regulated secretion of granules Yoshie et al., 2000
Rab27a,b Epithelial specific; melanosomes Exocytosis; (a) Transport of secretory granules, dense-core vesicles (with Rab3a) and lysosome-related organelles; myosin recruitment to melanosomes; (b) platelet specific, regulated secretion Barral et al., 2002; Futter, 2006; Tolmachova et al., 2007; Tsuboi and Fukuda, 2006
Rab37 Secretory granules (insulin and mast cell granules) Mast cell degranulation Masuda et al., 2000; Brunner et al., 2007
  • Uncharacterized Rab family members are highlighted in red.