Table 1.

Components of Weibel-Palade bodies

Component Abbreviation Protein Site of recruitment Expression regulated by Function References
von Willebrand factor VWF Secreted TGN Haemostasis Wagner et al., 1982
P-selectin Membrane TGN IL-4, Oncostatin M Leukocyte binding, haemostasis Bonfanti et al., 1989; Harrison-Lavoie et al., 2006
Osteoprotegerin OPG Secreted TGN TNFα, IL-1b Leukocyte binding Zannettino et al., 2005; Zauli et al., 2007
a1.3-Fucosyltransferase VI a1.3 FucT VI Secreted TGN* Selectin ligand modification – adhesion effects? Schnyder-Candrian et al., 2000
Angiopoietin-2 Ang-2 Secreted TGN* Autocrine regulator enhancing TNFα sensitisation Fiedler et al., 2006; Fiedler et al., 2004
Calcitonin gene-related peptide CGRP Secreted TGN* Possible vasodilator and upregulator of adhesion molecules Doi et al., 2001; Ozaka et al., 1997; Smith et al., 1993
Endothelin-1 and endothelin-converting enzyme ET-1 & ECE Secreted TGN* Vasoconstriction Doi et al., 2004; Doi et al., 2002; Nomiyama et al., 1998; Ozaka et al., 1997; Russell and Davenport, 1999; Russell et al., 1998a; Russell et al., 1998b; Sakamoto et al., 1993
Interleukin-8 IL-8 Secreted TGN* IL-1b, IL-1a, TNFα, LPS Activates integrin-mediated adhesion of leukocytes Oynebraten et al., 2004; Romani de Wit et al., 2003a; Utgaard et al., 1998; Wolff et al., 1998
Eotaxin-3 Secreted TGN* IL-4 Leukocyte recruitment Oynebraten et al., 2004
CD63 Membrane Post budding Membrane organisation/integrin interaction Harrison-Lavoie et al., 2006; Vischer and Wagner, 1993
Rab3D Membrane-associated Post budding WPBs size regulation Knop et al., 2004
Rab27A Membrane-associated Post budding General LRO maturation or exocytosis role? Hannah et al., 2003
  • * These components are presumed to be recruited at the TGN as they colocalise with all populations of WPBs; however, direct evidence remains to be established