Table 1.

Nuclear morphology of WT, Nesprin-2-Giant-deficient- and Nesprin-2ΔABD-expressing fibroblasts

Area (μm2) Perimeter (μm) Contour ratio
WT 104.4±4.1 38.5±1.5 0.85±0.03
Nesprin-2-Giant deficient 205.7±9.1 61.2±2.7 0.69±0.03
P value 7.15×10–83 9.2×10–118 2.96×10–98
Nesprin-2ΔABD 175.2±8.6 50.5±2.5 0.83±0.04
P value 9.45×10–41 1.75×10–49 3.9×10–7
  • Nuclear morphometric-parameter analysis of WT and mutant cells. Mean ± s.e.m. results and the corresponding P values (control versus mutant) are indicated. Measurements were performed in triplicate experiments and more than 500 cells were counted for each cell type