Table 3.

Partial exon-intron organization of Nesprin-2 Giant

Exon 5′ codon 3′ codon Exon size (bp) Intron size (bp)
1 1 1 79 24,186
2 2 3 62 1717
3 1 3 96 110
4 1 3 78 88
5 1 3 93 7576
6 1 2 188 1884
7 3 1 197 2660
8 2 3 101 3419
9 1 3 102 2447
10 1 3 138 4921
  • The nucleotide position (1, 2 or 3) of the codon triplets at the 5′ and 3′ ends in the individual exons (1-10) is indicated. Note that only alternative splicing involving exons 1 and 8 would ensure synthesis of a K56-386-reactive Nesprin-2ΔABD isoform in the KO mice. Exon and intron sizes are shown