Table 1.

In vitro IC50 (μM) of compounds that inhibit class I PI3K isoforms

p110α p110β p110δ p110γ
PW12 0.015 0.83 0.73 0.97
TGX-155 7.2 0.030 0.38 14.1
IC87114 >100 38 0.033 0.7
LY294002 0.85 0.24 0.68 3.1
  • Assays were conducted side by side using 10 μM ATP and 100 μg/ml phosphatidylinositol as the substrate