Table 1.

Factors involved in various aspects of peroxisome formation and maintenance in S. cerevisiae

Functional class S. cerevisiae gene
Import of peroxisomal matrix proteins PEX1, PEX2, PEX4, PEX5, PEX6, PEX7, PEX8, PEX10, PEX12, PEX13, PEX14, PEX15, PEX17, PEX18, PEX21, PEX22, DJP1
PMP biogenesis and de novo formation PEX3, PEX19a
Peroxisome morphology, replication and proliferation VPS1, DNM1, CAF4, MDV1, FIS1, PEX11, PEX25, PEX27, PEX28, PEX29, PEX30, PEX31, PEX32
Peroxisome inheritance INP1, INP2, MYO2, polarised actin cytoskeleton
  • a PEX16 is absent from S. cerevisiae. In Yarrowia lipolytica it is involved in peroxisome proliferation. In mammals, it is involved in peroxisomal membrane protein biogenesis and de novo formation. For other species-specific differences in factors involved in peroxisome formation and maintenance, we refer readers to Kiel et al. (Kiel et al., 2006)