Table 1.

Retromer cargo proteins

Cargo proteinSpecies identifiedSorting motifPhysiological processReference(s)
Vps10pYeastFYVFSNHydrolase sorting(Seaman et al., 1997; Cereghino et al., 1995; Nothwehr et al., 2000)
Ftr1pYeastHLPFTKNLQaIron transport(Strochlic et al., 2007).
Wntless/MIG-14Flies, Worms??Wnt secretion(Summarised in Eaton, 2008)
CED-1Worms??Apototic cell clearance(Chen et al., 2010)
CIMPRMammalsWLMHydrolase sorting(Seaman, 2004; Arighi et al., 2004; Seaman, 2007)
SortilinMammalsFLVHydrolase sorting(Seaman, 2007; Canuel et al., 2008)
DMT1-II/Slc11a2MammalsYLLIron transport(Tabuchi et al., 2010)
pIgA receptorMammals??Polymeric IgA transport(Vergés et al., 2004)
Crumbs (Crb)Mammals, Flies??Cell polarity(Pocha et al., 2011; Zhou et al., 2011)
SorL1/SorLAMammalsFTAFANSHYAPP localisation(Nielsen et al., 2007; Fjorback et al., 2012)
TGN38 and TGN46Mammals??Not known(Lieu and Gleeson, 2010; Chia et al., 2011)
β2-adrenergic receptorMammalsPDZ motifbGPCR(Temkin et al., 2011)
  • a Recognised by Snx3.

  • b Probably recognised by Snx27 but not retromer complex proteins.