Table 1.

Comparison of major pathological alterations in Krt1, Krt10, Krt1/10 and Krt17 knockout mice

ObservationK1K10K1/10K17
Major phenotypeInflammation, mildskin fragilityHyperkeratosisSevere skinfragilityAlopecia,inflammation
LethalityP0NoneP0None
Epid. fragil.MildNoneSevere
HyperkeratosisVery mildStrongVery mild
TNFα-dependent alopecia+
Hair shaft anomalies+
TEWL2×↑Unalt.Not doneNot done
Corn. envelope17% intact55% intact40% intactNot done
InvolucrinUnalt.ReducedNot done
LoricrinUnalt.ReducedNot done
FilaggrinUnalt.Unalt.Unalt.Not done
RepetinElevatedNot doneNot doneNot done
ProliferationUnalt.Unalt.Unalt.Not done
Compensatorykeratin expressionK5/14 ↑suprabasallyK5/14 ↑suprabasallyK16↑K14↑ in sweat glands
K6/16/17 ↑suprabasallyK6/16/17 ↑suprabasallyK6↑suprab., K16,K17 not done
K1/K14 filaments+
K5 or K6/K10filaments
Keratin aggregates+
DesmosomesUnalt.Unalt.Reduced sizeUnalt.
Desmosomal proteinsReduced amountUnalt.
E-cadherinUnalt.Reduced amountUnalt.
AMPsElevated
IL-18Elevated
IL-33Elevated
TSLPElevated
S100 A8/9Elevated
Elevated TNF sensitivityNot doneNot doneNot doneYes
  • Epid. fragil., epidermal fragility; Unalt., unaltered; suprab., suprabasal; ↑, an increase; +, present; −, absent. Data were compiled from knockout mice for Krt1 (this manuscript); Krt10 (Reichelt et al., 2001), Krt1/Krt10 (Wallace et al., 2012), Krt 17 (McGowan et al., 2002; Tong and Coulombe, 2006).