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β-Cell

  • RESEARCH ARTICLE
    Opposing effects of intracellular versus extracellular adenine nucleotides on autophagy: implications for β-cell function
    Tal Israeli, Yael Riahi, Ann Saada, Devorah Yefet, Erol Cerasi, Boaz Tirosh, Gil Leibowitz
    Journal of Cell Science 2018 131: jcs212969 doi: 10.1242/jcs.212969 Published 6 August 2018

    Summary: Adenosine and its metabolism by adenosine kinase regulate autophagy independent of nutrient availability and the canonical AMPK–mTORC1 pathway. In β-cells, adenosine regulates insulin secretion, in part, through modulation of autophagy.

  • RESEARCH ARTICLE
    Cell polarity defines three distinct domains in pancreatic β-cells
    Wan J. Gan, Michael Zavortink, Christine Ludick, Rachel Templin, Robyn Webb, Richard Webb, Wei Ma, Philip Poronnik, Robert G. Parton, Herbert Y. Gaisano, Annette M. Shewan, Peter Thorn
    Journal of Cell Science 2017 130: 143-151; doi: 10.1242/jcs.185116

    Summary: 3D imaging methods identify three structural and functional domains within β-cells in islets: apical, lateral and basal.

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