β-Cell
- Opposing effects of intracellular versus extracellular adenine nucleotides on autophagy: implications for β-cell function
Summary: Adenosine and its metabolism by adenosine kinase regulate autophagy independent of nutrient availability and the canonical AMPK–mTORC1 pathway. In β-cells, adenosine regulates insulin secretion, in part, through modulation of autophagy.
- Cell polarity defines three distinct domains in pancreatic β-cells
Summary: 3D imaging methods identify three structural and functional domains within β-cells in islets: apical, lateral and basal.