adherens junctions
- Calcium signaling mediates five types of cell morphological changes to form neural rosettes
Summary: Calcium signaling leads a morphogenetic process during neural rosette formation by regulating the movement of cell cytoskeletal elements.
- Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue
Summary: A FRET tension biosensor shows that tight junctions negatively regulate mechanical forces applied to adherens junctions. This regulation becomes essential when junctions are put under stress such as cytokinesis.
- Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier
Summary: Rap1 has been defined as an adhesion-promoting molecule but Rap1B is shown to promote adherens junction disassembly, whereas Rap1A is required for junction maintenance; both isoforms promote junction re-formation following injury.
- The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling
Highlighted Article: A previously unrecognized PDZ ligand motif in the RhoGAP protein DLC3 is shown to direct the protein to adherens junctions through interaction with the polarity protein Scribble, where it locally regulates RhoA.