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alpha-synuclein

  • RESEARCH ARTICLE
    Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells
    Claudio Bussi, Javier M. Peralta Ramos, Daniela S. Arroyo, Jose I. Gallea, Paolo Ronchi, Androniki Kolovou, Ji M. Wang, Oliver Florey, Maria S. Celej, Yannick Schwab, Nicholas T. Ktistakis, Pablo Iribarren
    Journal of Cell Science 2018 131: jcs226241 doi: 10.1242/jcs.226241 Published 30 November 2018

    Summary: Autophagy dynamics of microglial cells stimulated with the neuropathogenic protein alpha-synuclein (AS) show that autophagy is activated as a response to control AS-induced lysosomal damage.

  • SHORT REPORT
    Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
    Inês S. Amorim, Laura C. Graham, Roderick N. Carter, Nicholas M. Morton, Fella Hammachi, Tilo Kunath, Giuseppa Pennetta, Sarah M. Carpanini, Jean C. Manson, Douglas J. Lamont, Thomas M. Wishart, Thomas H. Gillingwater
    Journal of Cell Science 2017 130: 325-331; doi: 10.1242/jcs.194241

    Summary: Comparative proteomics revealed that mitochondrial proteins are a major target for α-synuclein. Sideroflexin 3 (SFXN3) was identified as one α-synuclein-dependent mitochondrial protein capable of altering synaptic morphology in vivo.

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