Alternative splicing
- Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway
Summary: Over 200 alternative splicing events implicated in protein transport at all stages of the secretory pathway are identified, globally establishing alternative splicing as a regulatory layer of membrane trafficking.
- CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis
Summary: Loss of CCAR-1 function during C. elegans embryogenesis results in dysregulated alternative splicing of unc-52 (the homolog of mammalian perlecan) and hemidesmosome disruption.
- How alternative splicing affects membrane-trafficking dynamics
Summary: This Review summarizes how trafficking is molecularly influenced by alternative splicing and how this interplay impacts physiology and pathological conditions.
- miRNA targeting and alternative splicing in the stress response – events hosted by membrane-less compartments
Summary: We review how the interplay between miRNA-based gene silencing of mRNAs and alternative splicing of pre-mRNAs are crucial post-transcriptional mechanisms that occur in liquid-like compartments to regulate cellular stress response.