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ATRX

  • RESEARCH ARTICLE
    PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
    Prashanth Krishna Shastrula, Isabel Sierra, Zhong Deng, Frederick Keeney, James E. Hayden, Paul M. Lieberman, Susan M. Janicki
    Journal of Cell Science 2019 132: jcs220970 doi: 10.1242/jcs.220970 Published 26 March 2019

    Summary: PML is recruited to a transgene array during S phase and represses DAXX-mediated histone H3.3 chromatin assembly. This suggests that PML coordinates H3.3 deposition with DNA replication at heterochromatin.

  • RESEARCH ARTICLE
    Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency
    Mingqi Han, Christine E. Napier, Sonja Frölich, Erdahl Teber, Ted Wong, Jane R. Noble, Eugene H. Y. Choi, Roger D. Everett, Anthony J. Cesare, Roger R. Reddel
    Journal of Cell Science 2019 132: jcs222349 doi: 10.1242/jcs.222349 Published 14 March 2019

    Summary: ATRX deficiency in cancer cells induces downregulation of PML, rendering the cells highly sensitive to lysis with ICP0-null mutant herpes simplex virus-1, with potential therapeutic applications.

  • RESEARCH ARTICLE
    Single-cell analysis of Daxx and ATRX-dependent transcriptional repression
    Alyshia Newhart, Ilona U. Rafalska-Metcalf, Tian Yang, Dmitri G. Negorev, Susan M. Janicki
    Journal of Cell Science 2012 125: 5489-5501; doi: 10.1242/jcs.110148

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