ATRX
- PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
Summary: PML is recruited to a transgene array during S phase and represses DAXX-mediated histone H3.3 chromatin assembly. This suggests that PML coordinates H3.3 deposition with DNA replication at heterochromatin.
- Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency
Summary: ATRX deficiency in cancer cells induces downregulation of PML, rendering the cells highly sensitive to lysis with ICP0-null mutant herpes simplex virus-1, with potential therapeutic applications.