Basal body
- Tetrahymena Poc5 is a transient basal body component that is important for basal body maturation
Highlighted Article: Loss of Tetrahymena thermophila Poc5 reveals an important role for this centrin-binding protein in basal body maturation, which also impacts basal body production and ciliogenesis.
- BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia
Highlighted Article: Bbs4−/− mice exhibited reduced olfactory sensory neuron cilia length/number and basal body number, as well as miscoordination of intraflagellar transport. Ectopic re-expression of BBS4 lengthened cilia, which alone was sufficient to rescue olfactory function.
- Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility
Summary: Perturbation of post-translational polyglutamylation affects early stages of spermatogenesis in mice: loss of the deglutamylase CCP5 completely prevents the formation of functional spermatocytes.
- RPGRIP1L helps to establish the ciliary gate for entry of proteins
Summary: RPGRIP1L, a key protein of the transition zone that is needed for NPHP4 localization, helps to exclude cytoplasmic proteins from the cilia in Chlamydomonas reinhardtii.
- Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation in Drosophila melanogaster
Summary: The membrane phospholipid PIP2, and the kinase that produces PIP2, called Skittles, are needed for normal ciliary transition zone morphology and function in the Drosophila male germline.
- Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella
Summary: We identify the region in IFT46 that is responsible for its basal body and ciliary localization. This sequence promotes interaction with IFT52, which recruits IFT46 to the basal body.
- WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
Summary: WDR8 is a centriolar and pericentriolar satellite protein. WDR8 is targeted to the centrioles by the proximal end protein Cep135. Cep135 and WDR8 are required for ciliary-vesicle docking during ciliogenesis.