BMPR2
- BMPR2 inhibits activin and BMP signaling via wild-type ALK2
Summary: Activation of SMAD1/5/8 via endogenous wild-type ALK2 by activin A, activin B and certain BMPs is enhanced when BMPR2 levels are knocked down.
- VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
Summary: We reveal the molecular mechanism by which BMP6 induces hyperpermeabilization of the endothelium. This provides first insights into the mechanism of BMP-dependent vascular integrity in normal physiology and disease.