Bone resorption
- Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro
Summary: Osteoblast lineage cells directly stimulate osteoclastic bone resorption and promote the aggressive trench-resorption mode by exerting a matrix metalloproteinase-dependent catabolic activity.
- Time-lapse reveals that osteoclasts can move across the bone surface while resorbing
Summary: Bone erosion requires that osteoclasts both resorb and migrate. According to common belief, these activities are mutually exclusive and alternate. Paradoxically, we show here simultaneous resorption and migration.